Obstetric pain: visual analog scale (VAS) and numerical rating scale (NRS) are correlated and have a modest but comparable sensitivity to detect a relief after epidural analgesia (EA)

Introduction Late termination of pregnancy combines psychological distress with severe physical pain. The present study evaluated the benefit of adding oral pregabalin to epidural analgesia during this procedure. Methods Healthy women were randomly allocated to receive either oral pregabalin 150 mg/12 h or prazepam 10 mg/12 h at the induction of the late termination of pregnancy procedure. When they felt abdominal pain (numerical rating scale ranging from 0 [no pain] to 100 [worst pain possible]), patient-controlled epidural analgesia was activated and set to deliver ropivacaine 0.1% with sufentanil 0.25 μg/ml, 5 ml/h with a bolus dose of 5 ml/30 min. Rescue analgesia was available as needed by administration of 10 ml ropivacaine 0.1% (pain score less than 60/100) or 0.2% (at least 60/100). The primary outcome was the consumption of epidural analgesics. Results Forty-eight patients participated in the study. Demographic and obstetric data were similar. Pregabalin reduced total ropivacaine consumption 11.3 ± 3.2 mg/h (mean ± SD) versus 15.1 ± 4.9 mg/h in the prazepam group (P = 0.005), an effect related to a decrease in the need for rescue analgesia. In the pregabalin group, fewer women asked for rescue dose (75 vs. 96%; P = 0.048), and the number of rescue doses per patient was reduced (1 [0-2] vs. 2 [1-3]); median [interquartile range], P = 0.005), particularly the need for ropivacaine 0.2%. Discussion This is the first study considering the use of pregabalin for labor pain associated with late termination of pregnancy, showing that pregabalin 150 mg/12 h is a helpful adjuvant to epidural analgesia. Modulation of both visceral sensitization and affective component of pain may contribute to the benefits observed.

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Musculoskeletal complications of diabetes post COVID-19

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20215008 ◽

2021 ◽

Vol 9 (1) ◽

pp. 263

Author(s):

Vijay Krishna Kumar A. K. ◽

Ashwini Ganesan ◽

Suruthi Raju

Keyword(s):

Diabetes Mellitus ◽

Rating Scale ◽

Numerical Rating Scale ◽

Severe Disease ◽

Multiple Organ ◽

Organ System ◽

Disease Course ◽

Analog Scale ◽

Patients With Diabetes ◽

Numerical Rating

Background: COVID-19 is an emerging disease caused by the severe respiratory syndrome. This affects the respiratory system but directly or indirectly affects the multiple organ system, including the musculoskeletal system. The patients with diabetes who get COVID are at risk of a severe disease course and mortality.Methods: The study design is Observational study. The study will be conducted on 30patients who have recovered from covid-19 with diabetes mellitus. The samples of the study are selected randomly. The data will be collected in a non-homogenous way, especially regarding lifestyle habits, and severity of the illness. Myalgia was calculated by numerical rating scale, Arthralgia was calculated by visual analog scale, and fatigue was calculated by Chalder fatigue scale to assess the severity of fatigue.Results: The severity of the complication was decreased in patients with second month COVID-19 recovery than in the first month.Conclusions: Background: COVID-19 is an emerging disease caused by the severe respiratory syndrome. This affects the respiratory system but directly or indirectly affects the multiple organ system, including the musculoskeletal system. The patients with diabetes who get COVID are at risk of a severe disease course and mortality.Methods: The study design is Observational study. The study will be conducted on 30patients who have recovered from covid-19 with diabetes mellitus. The samples of the study are selected randomly. The data will be collected in a non-homogenous way, especially regarding lifestyle habits, and severity of the illness. Myalgia was calculated by numerical rating scale, Arthralgia was calculated by visual analog scale, and fatigue was calculated by Chalder fatigue scale to assess the severity of fatigue.Results: The severity of the complication was decreased in patients with second month COVID-19 recovery than in the first month.Conclusions: This study concluded that there is decrease in the severity of musculoskeletal complications in diabetic patients from 1st month to 2nd month COVID-19 recoveries.

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