CORRELATION BETWEEN SEROTYPE-SPECIFIC IgG AND OPA LEVELS FOLLOWING VACCINATION WITH PNEUMOCOCCAL CONJUGATE VACCINES

2016 ◽  
Author(s):  
Katrina Nolan
Keyword(s):  
Conjugate Vaccines ◽  
Pneumococcal Conjugate Vaccines ◽  
Specific Igg

scholarly journals Intranasal Immunization with Pneumococcal Conjugate Vaccines with LT-K63, a Nontoxic Mutant of Heat-Labile Enterotoxin, as Adjuvant Rapidly Induces Protective Immunity against Lethal Pneumococcal Infections in Neonatal Mice

2002 ◽  
Vol 70 (3) ◽  
pp. 1443-1452 ◽  
Author(s):  
Håvard Jakobsen ◽  
Stefania Bjarnarson ◽  
Giuseppe Del Giudice ◽  
Monique Moreau ◽  
Claire-Anne Siegrist ◽  
...  
Keyword(s):  
Early Life ◽  
Protective Immunity ◽  
Protective Efficacy ◽  
Antibody Responses ◽  
Mucosal Immunization ◽  
Pneumococcal Infections ◽  
Conjugate Vaccines ◽  
Pneumococcal Conjugate Vaccines ◽  
Serotype 1 ◽  
Specific Igg

ABSTRACT Immunization with pneumococcal polysaccharides (PPS) conjugated to tetanus toxoid (TT) (Pnc-TT) elicits protective immunity in an adult murine pneumococcal infection model. To assess immunogenicity and protective immunity in early life, neonatal (1 week old) and infant (3 weeks old) mice were immunized intranasally (i.n.) or subcutaneously (s.c.) with Pnc-TT of serotype 1 (Pnc1-TT). Anti-PPS-1 and anti-TT immunoglobulin G (IgG) and IgM antibodies were measured in serum and saliva, and vaccine-induced protection was evaluated by i.n. challenge with serotype 1 pneumococci. Pnc1-TT was immunogenic in neonatal and infant mice when administered s.c. without adjuvant: a majority of the young mice were protected from bacteremia and a reduction of pneumococcal density in the lungs was observed, although antibody responses and protective efficacy remained lower than in adults. The addition of LT-K63, a nontoxic mutant of heat-labile enterotoxin, as adjuvant significantly enhanced PPS-1-specific IgG responses and protective efficacy following either s.c. or i.n. Pnc1-TT immunization. Mucosal immunization was particularly efficient in neonates, as a single i.n. dose of Pnc1-TT and LT-K63 induced significantly higher PPS-1-specific IgG responses than s.c. immunization and was sufficient to protect neonatal mice against pneumococcal infections, whereas two s.c. doses were required to induce complete protection. In addition, i.n. immunization with Pnc1-TT and LT-K63 induced a vigorous salivary IgA response. This suggests that mucosal immunization with pneumococcal conjugate vaccines and LT-K63 may be able to circumvent some of the limitations of neonatal antibody responses, which are required for protective immunity in early life.

Economic evaluation of second generation pneumococcal conjugate vaccines in Norway

Vaccine ◽  
2011 ◽  
Vol 29 (47) ◽  
pp. 8564-8574 ◽  
Author(s):  
Bjarne Robberstad ◽  
Carl R. Frostad ◽  
Per E. Akselsen ◽  
Kari J. Kværner ◽  
Aud K.H. Berstad
Keyword(s):  
Economic Evaluation ◽  
Second Generation ◽  
Conjugate Vaccines ◽  
Pneumococcal Conjugate Vaccines
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