Cognitive decline in the streptozotocin-induced model of Alzheimer’s disease may be related to impairment in adult neurogenesis and astrogliosis

2016 ◽  
Author(s):  
Taysa Bassani
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Adult Neurogenesis ◽  
Model Of Alzheimer’S Disease

scholarly journals Gestational Stress Augments Postpartum β-Amyloid Pathology and Cognitive Decline in a Mouse Model of Alzheimer’s Disease

2018 ◽  
Vol 29 (9) ◽  
pp. 3712-3724 ◽  
Author(s):  
Zahra Jafari ◽  
Jogender Mehla ◽  
Bryan E Kolb ◽  
Majid H Mohajerani
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Cognitive Decline ◽  
Noise Exposure ◽  
Amyloid Β ◽  
Control Group ◽  
Plaque Size ◽  
Model Of Alzheimer’S Disease ◽  
Gestational Stress

Abstract Besides well-known risk factors for Alzheimer’s disease (AD), stress, and in particular noise stress (NS), is a lifestyle risk factor common today. It is known that females are at a significantly greater risk of developing AD than males, and given that stress is a common adversity in females during pregnancy, we hypothesized that gestational noise exposure could exacerbate the postpartum development of the AD-like neuropathological changes during the life span. Pregnant APPNL-G-F/NL-G-F mice were randomly assigned to either the stress condition or control group. The stress group was exposed to the NS on gestational days 12–16, which resulted in a markedly higher hypothalamic–pituitary–adrenal (HPA) axis responsivity during the postpartum stage. Higher amyloid-β (Aβ) deposition and larger Aβ plaque size in the olfactory area were the early onset impacts of the gestational stress (GS) seen at the age of 4 months. This pattern of increased Aβ aggregation and larger plaque size were observed in various brain areas involved in both AD and stress regulation, especially in limbic structures, at the age of 6 months. The GS also produced anxiety-like behavior, deficits in learning and memory, and impaired motor coordination. The findings suggest that environmental stresses during pregnancy pose a potential risk factor in accelerating postpartum cognitive decline and AD-like neuropathological changes in the dams (mothers) later in life.

scholarly journals Modifications of Hippocampal Circuits and Early Disruption of Adult Neurogenesis in the Tg2576 Mouse Model of Alzheimer’s Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e76497 ◽  
Author(s):  
Alice Krezymon ◽  
Kevin Richetin ◽  
Hélène Halley ◽  
Laurent Roybon ◽  
Jean-Michel Lassalle ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Adult Neurogenesis ◽  
Tg2576 Mouse ◽  
Model Of Alzheimer’S Disease

scholarly journals Correction to: ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

2020 ◽  
Vol 140 (5) ◽  
pp. 791-791
Author(s):  
Charles E. Evans ◽  
James S. Miners ◽  
Giulia Piva ◽  
Christine L. Willis ◽  
David M. Heard ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Cognitive Decline ◽  
Tg2576 Mouse ◽  
Amyloid Pathology ◽  
Model Of Alzheimer’S Disease

Amplifying mitochondrial function rescues adult neurogenesis in a mouse model of Alzheimer's disease

2017 ◽  
Vol 102 ◽  
pp. 113-124 ◽  
Author(s):  
Kevin Richetin ◽  
Manon Moulis ◽  
Aurélie Millet ◽  
Macarena S. Arràzola ◽  
Trinovita Andraini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Adult Neurogenesis ◽  
Mitochondrial Function ◽  
Model Of Alzheimer’S Disease
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