Bilateral medullary thyroid microcarcinomas associated with neoplastic C-cell hyperplasia and primary hiperparathiroidism, suggestive for a MEN2A syndrome

2016 ◽  
Author(s):  
Angela Borda
Keyword(s):  
Cell Hyperplasia ◽  
Medullary Thyroid ◽  
C Cell Hyperplasia ◽  
C Cell

Prevalence of C-cell hyperplasia and medullary thyroid carcinoma in a consecutive series of pheochromocytoma patients

1984 ◽  
Vol 8 (4) ◽  
pp. 493-500 ◽  
Author(s):  
Svante Jansson ◽  
Göran Hansson ◽  
Håkan Salander ◽  
Gunnar Stenström ◽  
Lars -Erik Tisell
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Consecutive Series ◽  
Cell Hyperplasia ◽  
Medullary Thyroid ◽  
C Cell Hyperplasia ◽  
C Cell

scholarly journals Calcitonin concentrations in patients with chronic kidney disease and medullary thyroid carcinoma or c-cell hyperplasia

2006 ◽  
Vol 70 (11) ◽  
pp. 2014-2020 ◽  
Author(s):  
K.A. Borchhardt ◽  
H. Heinzl ◽  
A. Gessl ◽  
W.H. Hörl ◽  
K. Kaserer ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Cell Hyperplasia ◽  
Medullary Thyroid ◽  
C Cell Hyperplasia ◽  
C Cell

C-Cell Hyperplasia and Medullary Thyroid Carcinoma in Patients Routinely Screened for Serum Calcitonin

1998 ◽  
Vol 22 (6) ◽  
pp. 722-728 ◽  
Author(s):  
Klaus Kaserer ◽  
Christian Scheuba ◽  
Nikolaus Neuhold ◽  
Andreas Weinhäusel ◽  
Heinrich Vierhapper ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Cell Hyperplasia ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
C Cell Hyperplasia ◽  
C Cell

Differential expression of galectin-3 in medullary thyroid carcinoma and C-cell hyperplasia

2002 ◽  
Vol 57 (6) ◽  
pp. 813-819 ◽  
Author(s):  
Antongiulio Faggiano ◽  
Monique Talbot ◽  
Ludovic Lacroix ◽  
Jean Michel Bidart ◽  
Eric Baudin ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Differential Expression ◽  
Medullary Thyroid Carcinoma ◽  
Cell Hyperplasia ◽  
Medullary Thyroid ◽  
C Cell Hyperplasia ◽  
C Cell ◽  
Galectin 3

scholarly journals MON-457 Reactive Thyroid C-Cell Hyperplasia or Medullary Thyroid Cancer in a Patient with Nodular Thyroidopathy. May the Calcitonin Measurement in Fine-Needle Aspirate Washout Fluid of the Healthy Lobe Help to Define These Conditions?

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Anastassia Chevais ◽  
Dmitry Beltsevich ◽  
Vladimir Vanushko ◽  
Alexander Mikheenkov ◽  
Daria Ladygina ◽  
...  
Keyword(s):  
Needle Aspiration ◽  
Receptor Activation ◽  
Morphological Data ◽  
Fluid Sample ◽  
Cell Hyperplasia ◽  
Medullary Thyroid ◽  
Fine Needle ◽  
C Cell Hyperplasia ◽  
C Cell

Abstract Background: Serum basal calcitonin (bCT) is used as a biomarker of medullary thyroid carcinoma (MTC) but bCT can also be elevated in patients with hypercalcemias, hypergastrinemias, thyroiditis, neuroendocrine tumors, renal end-stage kidney disease, obesity and cigarette smoking. The application of bCT and calcitonin measured in the FNA washout fluid sample (FNA-CT) for screening certain patients with nodular thyroidopathy can be controversial. Case: A 44 yo patient presented with elevated bCT level - 24pg/ml (N for male <18). He had a morbid obesity (BMI-45kg/m2) and thereby received GLP-1 receptor agonists Liraglutide 18 mg in total throughout one month. The ultrasound thyroid examination showed 2 nodules in the right lobe: 11mm and 9 mm (EU-TIRADS 2 and 4). Thyroid nodules were evaluated by fine needle aspiration biopsy (FNAB) which revealed benign colloid nodules (Bethesda II). Following the most updated ATA guidelines, to accurately diagnose MTC we performed FNA-CT measurement. The concentration from both nodules exceeded the upper reporting range of 2000 pg/ml. The patient stopped his therapy with Liraglutide and after one month of following, his bCT dropped at 18 pg/ml. He underwent a second workup with same results. We examined FNA-CT of contralateral healthy lobe and obtained 913 pg/ml. After this case, 17 patients with high-normal rate of bCT: 14 of them had a nodule (Bethesda II) and elevated FNA-CT of healthy tissue of the contralateral lobe (>2000 pg/ml) were determined in follow-up group. The remaining 3 patients with nodules (Bethesda IV-VI) and FNA-CT of healthy lobe which did not exceed bCT rate, were operated. MTC was confirmed. Discussion: Our patient had not only many factors which can occur his bCT level (obesity, smoking), but also unfavourable FNA washout results. Additionally, since in clinical studies GLP-1 receptor activation has been associated with C-cell hyperplasia (CCH), we cannot completely exclude the possible effect of this treatment on patient’s bCT level. We confronted a situation when, on the one hand, FNA-CT data indicate the MTC nature of hypercalcitoninemia, but on the other hand, decreasing bCT-level in dynamic observation is not common for MTC. FNAB of the healthy lobe and obtaining high rates of CT in the washout fluid sample allowed us to confirm the diffuse CCH process, thus to follow up these patients. CT stimulation test cannot distinguish between minimal MTC and CCH and has no reference range. The weak point of the proposed study is the lack of morphological data in the follow-up group of patients. Conclusion: It is possible to use rate of FNA-CT of the healthy lobe to differentiate between various C-cell diseases, but requires new data.

The Influence of Gender, Age, and RET Polymorphisms on C-Cell Hyperplasia and Medullary Thyroid Carcinoma

Thyroid ◽  
2008 ◽  
Vol 18 (12) ◽  
pp. 1269-1276 ◽  
Author(s):  
Andreas Weinhaeusel ◽  
Christian Scheuba ◽  
Martin Lauss ◽  
Albert Kriegner ◽  
Klaus Kaserer ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Cell Hyperplasia ◽  
Medullary Thyroid ◽  
C Cell Hyperplasia ◽  
C Cell

Immunohistological Studies of Medullary Thyroid Carcinoma and C Cell Hyperplasia*

1980 ◽  
Vol 51 (4) ◽  
pp. 857-862 ◽  
Author(s):  
LEONARD J. DEFTOS ◽  
HENRY G. BONE ◽  
JACQUELINE G. PARTHEMORE ◽  
DOUGLAS W. BURTON
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Cell Hyperplasia ◽  
Medullary Thyroid ◽  
C Cell Hyperplasia ◽  
C Cell

scholarly journals C-cell hyperplasia in sporadic and familial medullary thyroid carcinoma

2018 ◽  
Vol 61 (4) ◽  
pp. 485 ◽  
Author(s):  
Mahima Yadav ◽  
Vinita Agrawal ◽  
KrushnaChandra Pani ◽  
Ritu Verma ◽  
Sushila Jaiswal ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Cell Hyperplasia ◽  
Medullary Thyroid ◽  
Familial Medullary Thyroid Carcinoma ◽  
C Cell Hyperplasia ◽  
C Cell
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