A pancreatic serous cystic neoplasm coexisting with high-grade pancreatic intraepithelial neoplasia mimicking an intraepithelial papillary mucinous neoplasm: A case report

2016 ◽  
Author(s):  
Yoshiaki Kawaguchi
Keyword(s):  
Case Report ◽  
Intraepithelial Neoplasia ◽  
Cystic Neoplasm ◽  
High Grade ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Mucinous Neoplasm ◽  
Serous Cystic Neoplasm

scholarly journals A Serous Cystic Neoplasm of the Pancreas Coexisting with High-Grade Pancreatic Intraepithelial Neoplasia Mimicking an Intraepithelial Papillary Mucinous Neoplasm: A Case Report

2017 ◽  
Vol 10 (1) ◽  
pp. 143-150 ◽  
Author(s):  
Aya Kawanishi ◽  
Kenichi Hirabayashi ◽  
Hirotaka Kono ◽  
Yumi Takanashi ◽  
Atsuko Hadano ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Pancreatic Duct ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Main Pancreatic Duct ◽  
Cystic Lesion ◽  
Cystic Neoplasm ◽  
Pancreatic Ducts ◽  
High Grade ◽  
Mucinous Neoplasm ◽  
Serous Cystic Neoplasm

Serous cystic neoplasms of the pancreas are rare exocrine pancreatic neoplasms, most of which are benign and do not communicate with the pancreatic duct. Pancreatic intraepithelial neoplasm (PanIN) is considered a precursor of ductal adenocarcinoma that is microscopically recognized in pancreatic ducts. A 67-year-old Japanese woman presented with a 10-mm multilocular cystic lesion at the pancreatic body. Magnetic resonance pancreatography showed stenosis of the main pancreatic duct at the pancreatic body and dilatation of the distal side of the main pancreatic duct. Furthermore, communication between the cystic lesion and the main pancreatic duct was suspected based on magnetic resonance pancreatography findings. Distal pancreatectomy was performed under the preoperative diagnosis of intraductal papillary mucinous neoplasm. Histologically, the cystic lesion was lined with a non-atypical cuboidal or flat epithelium with clear cytoplasm and was thus diagnosed as a serous cystic neoplasm. High-grade PanIN lesions with stromal fibrosis were observed at the main and branch pancreatic ducts. Histological examination revealed no communication between the serous cystic neoplasm and the pancreatic ducts. Immunohistochemically, the epithelium of the serous cystic neoplasm showed positive anti-von Hippel-Lindau antibody staining, whereas the epithelium of the PanIN showed negative staining. A serous cystic neoplasm coexisting with another pancreatic neoplasm is rare. When dilatation of the main or branch pancreatic ducts coexists with a serous cystic neoplasm, as in this case, the lesion clinically mimics an intraductal papillary mucinous neoplasm.

scholarly journals Classification, Morphology, Molecular Pathogenesis, and Outcome of Premalignant Lesions of the Pancreas

2017 ◽  
Vol 141 (12) ◽  
pp. 1606-1614 ◽  
Author(s):  
Meredith E. Pittman ◽  
Rema Rao ◽  
Ralph H. Hruban
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Intraepithelial Neoplasia ◽  
Mucinous Cystic Neoplasm ◽  
Premalignant Lesions ◽  
Ductal Adenocarcinoma ◽  
Cystic Neoplasm ◽  
Precursor Lesions ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Mucinous Neoplasm

Context.— Invasive pancreatic ductal adenocarcinoma has a greater than 90% mortality rate at 5 years. Understanding noninvasive, curable precursor lesions gives us the best hope for reducing mortality from pancreatic ductal adenocarcinoma. The 3 pancreatic precursor lesions that have been well studied include intraductal papillary mucinous neoplasm, mucinous cystic neoplasm, and pancreatic intraepithelial neoplasia. Objective.— To give an update on the latest clinical, molecular, and pathologic advances in intraductal papillary mucinous neoplasm, mucinous cystic neoplasm, and pancreatic intraepithelial neoplasia for the general surgical pathologist. Data Sources.— The current literature was analyzed and the authors' experiences with institutional and consult material were incorporated. Conclusions.— Our understanding of the molecular alterations that lead from pancreatic precursor lesion to invasive carcinoma continues to evolve. These advances aid clinicians in their treatment decisions and researchers in their search for actionable, druggable targets.

A case of high‐grade pancreatic intraepithelial neoplasia concomitant with type 1 autoimmune pancreatitis: The process underlying both conditions

2019 ◽  
Vol 69 (3) ◽  
pp. 165-171
Author(s):  
Tomoko Sugiyama ◽  
Takuma Tajiri ◽  
Shinichiro Hiraiwa ◽  
Tomohisa Machida ◽  
Hiroyuki Ito ◽  
...  
Keyword(s):  
Autoimmune Pancreatitis ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Type 1 Autoimmune Pancreatitis

scholarly journals Molecular Characteristics of Pancreatic Ductal Adenocarcinomas with High-Grade Pancreatic Intraepithelial Neoplasia (PanIN) Are Different from Those without High-Grade PanIN

Pathobiology ◽  
2017 ◽  
Vol 84 (4) ◽  
pp. 192-201 ◽  
Author(s):  
Tetsuyuki Miyazaki ◽  
Yoshihiro Ohishi ◽  
Yoshihiro Miyasaka ◽  
Yasunori Oda ◽  
Shinichi Aishima ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Molecular Characteristics ◽  
High Grade ◽  
Pancreatic Intraepithelial Neoplasia

scholarly journals Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4

2017 ◽  
Vol 242 (1) ◽  
pp. 16-23 ◽  
Author(s):  
Waki Hosoda ◽  
Peter Chianchiano ◽  
James F Griffin ◽  
Meredith E Pittman ◽  
Lodewijk AA Brosens ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Genetic Analyses

scholarly journals Developmental Pathways Direct Pancreatic Cancer Initiation from Its Cellular Origin

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Maximilian Reichert ◽  
Karin Blume ◽  
Alexander Kleger ◽  
Daniel Hartmann ◽  
Guido von Figura
Keyword(s):  
Pancreatic Cancer ◽  
Poor Prognosis ◽  
Intraepithelial Neoplasia ◽  
Developmental Pathways ◽  
Ductal Adenocarcinoma ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Cellular Origin ◽  
Mucinous Neoplasm ◽  
Cancer Initiation ◽  
Advanced Stages

Pancreatic ductal adenocarcinoma (PDA) is characterized by an extremely poor prognosis, since it is usually diagnosed at advanced stages. In order to employ tools for early detection, a better understanding of the early stages of PDA development from its main precursors, pancreatic intraepithelial neoplasia (PanIN), and intraductal papillary mucinous neoplasm (IPMN) is needed. Recent studies on murine PDA models have identified a different exocrine origin for PanINs and IPMNs. In both processes, developmental pathways direct the initiation of PDA precursors from their cellular ancestors. In this review, the current understanding of early PDA development is summarized.

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