Helicobacter pylori Eradication effect on Liver Fat Content in Patient with Non-Alcoholic Fatty Liver Disease

AbstractNon-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease. However, the treatment is limited. The aim of this meta-analysis was to evaluate the effects and safety of sitagliptin, a selective inhibitor of dipeptidyl peptidase-4 (DPP-4I), in treating NAFLD. Studies were sourced from electronic databases including PubMed, CENTRAL (Cochrane Controlled Trials Register), Embase, Medline, Web of Science, Clinical Trials, and CNKI to identify all randomized controlled clinical trials (RCTs) and non-RCTs in adult patients with NAFLD. Key outcomes were changes in serum levels of liver enzymes and improvement in hepatic histology and fat content measured by imaging or liver biopsy. Stata14.0 and RevMan5.3 were used for the meta-analysis. Seven studies with 269 NAFLD patients were included. Compared to the control group, sitagliptin treatment improved serum gamma-glutamyl transpeptidase (GGT) levels in the RCT subgroup (SMD = 0.79, 95% CI: 0.01–1.58). However, there was no significant improvement in serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels following sitagliptin treatment. Four of the included studies performed liver imaging, but sitagliptin treatment did not result in a significant reduction in liver fat content. Only five participants developed sitagliptin-related gastrointestinal discomfort. Our study suggests that sitagliptin effects individuals with NAFLD by improving serum GGT. Although sitagliptin is safe and well tolerated in NAFLD patients, it exerts no beneficial effects on liver transaminase and liver fat content in these patients.

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Thyroid function and non-alcoholic fatty liver disease in hyperthyroidism patients

BMC Endocrine Disorders ◽

10.1186/s12902-021-00694-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Bairong Wang ◽

Baomin Wang ◽

Yumei Yang ◽

Jing Xu ◽

Mengyang Hong ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Thyroid Function ◽

Fatty Liver Disease ◽

Color Doppler ◽

Fat Content ◽

Liver Fat ◽

Liver Fat Content ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Abstract Background Although thyroid function has been demonstrated to be associated with non-alcoholic fatty liver disease (NAFLD) in different population, the prevalence and features of NAFLD in hyperthyroidism have not been reported. The present study aims to investigate the prevalence of NAFLD and association of thyroid function and NAFLD in hyperthyroidism patients. Methods This cross-sectional study was performed in Zhongshan Hospital, Fudan University, China. A total 117 patients with hyperthyroidism were consecutively recruited from 2014 to 2015. Thyroid function and other clinical features were measured, liver fat content was measured by color Doppler ultrasonically, NAFLD was defined in patients with liver fat content more than 9.15%. Statistical analyses were performed with SPSS software package version 13.0. Results The prevalence of NAFLD was 11.97% in hyperthyroidism. Patient with NAFLD had lower free triiodothyronine (FT3) and free thyroxine (FT4) levels than patients without NAFLD (P < 0.05). After adjusting for age, gender, metabolic parameters and inflammation factors, higher FT3 were associated with lower liver fat content (β = − 0.072, P = 0.009) and decreased odds ratio of NAFLD (OR = 0.267, 95%CI 0.087–0.817, P = 0.021). Conclusions FT3 level was negatively associated with the liver fat content in this population. These results may provide new evidence in the role of thyroid hormone on the regulation of liver fat content and NAFLD.

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Thyroid function and non-alcoholic fatty liver disease in hyperthyroidism patients

10.21203/rs.3.rs-54593/v3 ◽

2021 ◽

Author(s):

Bairong Wang ◽

Baomin Wang ◽

Yumei Yang ◽

Jing Xu ◽

Mengyang Hong ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Thyroid Function ◽

Fatty Liver Disease ◽

Color Doppler ◽

Fat Content ◽

Liver Fat ◽

Liver Fat Content ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Abstract Background: Although thyroid function has been demonstrated to be associated with non-alcoholic fatty liver disease (NAFLD) in different population, the prevalence and features of NAFLD in hyperthyroidism have not been reported. The present study aims to investigate the prevalence of NAFLD and association of thyroid function and NAFLD in hyperthyroidism patients.Methods: This cross-sectional study was performed in Zhongshan Hospital, Fudan University, China. A total 117 patients with hyperthyroidism were consecutively recruited from 2014-2015. Thyroid function and other clinical features were measured, liver fat content was measured by color Doppler ultrasonically,NAFLD was defined in patients with liver fat content more than 9.15% . Statistical analyses were performed with SPSS software package version 13.0.Results: The prevalence of NAFLD was 11.97% in hyperthyroidism. Patient with NAFLD had lower free triiodothyronine (FT3) and free thyroxine (FT4) levels than patients without NAFLD (P < 0.05). After adjusting for age, gender, metabolic parameters and inflammation factors, higher FT3 were associated with lower liver fat content (β=－0.072, P=0.009) and decreased odds ratio of NAFLD (OR=0.267, 95%CI 0.087-0.817, P=0.021). Conclusions: FT3 level was negatively associated with the liver fat content in this population. These results may provide new evidence in the role of thyroid hormone on the regulation of liver fat content and NAFLD.

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Liver fat content, non-alcoholic fatty liver disease, and risk of ischaemic heart disease

European Heart Journal ◽

10.1093/eurheartj/ehy237 ◽

2018 ◽

Vol 39 (36) ◽

pp. 3398-3398 ◽

Cited By ~ 1

Author(s):

Christopher D Byrne ◽

Giovanni Targher

Keyword(s):

Heart Disease ◽

Liver Disease ◽

Fatty Liver ◽

Ischaemic Heart Disease ◽

Fatty Liver Disease ◽

Fat Content ◽

Liver Fat ◽

Liver Fat Content ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Associations of HDL Subspecies Defined by ApoC3 with Non-Alcoholic Fatty Liver Disease: The Multi-Ethnic Study of Atherosclerosis

Journal of Clinical Medicine ◽

10.3390/jcm9113522 ◽

2020 ◽

Vol 9 (11) ◽

pp. 3522

Author(s):

Jakub Morze ◽

Manja Koch ◽

Sarah A. Aroner ◽

Matthew Budoff ◽

Robyn L. McClelland ◽

...

Keyword(s):

Cardiovascular Disease ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Fat Content ◽

Liver Fat ◽

Lower Prevalence ◽

Liver Fat Content ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Previously, we reported that inverse associations of high-density lipoprotein (HDL) with cardiovascular disease and diabetes were only observed for HDL that lacked the pro-inflammatory protein apolipoprotein C3 (apoC3). To provide further insight into the cardiometabolic properties of HDL subspecies defined by the presence or absence of apoC3, we aimed to examine these subspecies with liver fat content and non-alcoholic fatty liver disease (NAFLD). We investigated cross-sectional associations between ELISA-measured plasma levels of apoA1 in HDL that contained or lacked apoC3 and computed tomography-determined liver fat content and NAFLD (<51 HU) at baseline (2000–2002) among 5007 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) without heavy alcohol consumption (>14 drinks/week in men and >7 drinks/week in women). In multivariable-adjusted regression models, apoA1 in HDL that contained or lacked apoC3 was differentially associated with liver fat content (Pheterogeneity = 0.048). While apoA1 in HDL that lacked apoC3 was inversely associated with liver fat content (Ptrend < 0.0001), apoA1 in HDL that contained apoC3 was not statistically significantly associated with liver fat content (Ptrend = 0.57). Higher apoA1 in HDL that lacked apoC3 was related to a lower prevalence of NAFLD (OR per SD: 0.80; 95% CI: 0.72, 0.89), whereas no association was found for apoA1 in HDL that contained apoC3 (OR per SD: 0.95; 95% CI: 0.85, 1.05; Pheterogeneity = 0.09). Higher apoA1 in HDL that lacked apoC3 was associated with less liver fat content and a lower prevalence of NAFLD. This finding extends the inverse association of HDL lacking apoC3 from cardiovascular disease to NAFLD. Lack of biopsy-proven hepatic steatosis and fibrosis data requires the replication of our study in further studies.

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Thyroid function and non-alcoholic fatty liver disease in hyperthyroidism patients

10.21203/rs.3.rs-54593/v2 ◽

2020 ◽

Author(s):

Bairong Wang ◽

Baomin Wang ◽

Yumei Yang ◽

Jing Xu ◽

Mengyang Hong ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Thyroid Function ◽

Fatty Liver Disease ◽

Color Doppler ◽

Fat Content ◽

Liver Fat ◽

Liver Fat Content ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Abstract Background: Although thyroid function has been demonstrated to be associated with non-alcoholic fatty liver disease (NAFLD) in different population, the prevalence and features of NAFLD in hyperthyroidism have not been reported. The present study aims to investigate the prevalence of NAFLD and association of thyroid function and NAFLD in hyperthyroidism patients. Methods: This cross-sectional study was performed in Zhongshan Hospital, Fudan University, China. A total 117 patients with hyperthyroidism were consecutively recruited from 2014-2015. Thyroid function and other clinical features were measured, liver fat content was measured by color Doppler ultrasonically, NFALD NAFLD was defined in patients with liver fat content more than 9.15% . Statistical analyses were performed with SPSS software package version 13.0.Results: The prevalence of NAFLD was 11.97% in hyperthyroidism. Patient with NAFLD had lower free triiodothyronine (FT3)fT3 and free thyroxine (FT4)fT4 levels than patients without NAFLD (P < 0.05). After adjusting for age, gender, metabolic parameters and inflammation factors, higher fT3 FT3 were associated with lower liver fat content (β=－0.072, P=0.009) and decreased odds ratio of NAFLD (OR=0.267, 95%CI 0.087-0.817, P=0.021). Conclusions: The prevalence of NAFLD was 11.97% in hyperthyroidism patients, and FT3 level was negatively associated with the liver fat content in this population. These results may provide new evidence in the role of thyroid hormone on the regulation of liver fat content and NAFLD.

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