EMBRACE(TM) VERSUS CONVENTIONAL CARE DURING TRANSPORT OF NEWBORN >1500 GRAMS: A RANDOMIZED DOUBLE BLIND CONTROLLED TRIAL AT TERTIARY CARE CENTRE IN GUJARAT, INDIA

BACKGROUND From the last century to modern days, there has been a paradigm shift in the field of thyroid surgery. Initially what was a dreadful surgery with multi fold serious complications, now with the advent of modern surgical technique (bipolar to nerve monitoring & emerging use of microscope), and better knowledge of anatomy, it has become one of the most frequently performed surgeries worldwide with very few complications. In spite of all these, postoperative complications like recurrent laryngeal nerve (RLN) palsy is still mostly feared by surgeons and still is one of the most frequent complications. METHODS This was a prospective nonrandomised controlled trial conducted among 60 study participants in the Department of Otorhinolaryngology and Head & Neck Surgery, of a tertiary care centre in West Bengal from July 2016 to June 2018. In this study two different surgical techniques were applied in two patient groups. In one group subcapsular dissection of thyroid gland was done without exploration of recurrent laryngeal nerve course in neck; and in another group, the complete course of the aforesaid nerve in the neck was explored and preserved. The postoperative functional status of RLN was assessed by fibreoptic laryngoscopy immediately after recovery from anaesthesia and in postoperative follow ups. We wanted to compare the outcome (in terms of functional status of RLN) in these two groups. RESULTS 3 patients (10 % cases) of nerve palsy were seen among 30 patients of subcapsular dissection group, whereas only one case (3.3 %) of nerve palsy was seen amongst 30 cases of complete exploration of recurrent laryngeal nerve. CONCLUSIONS Thyroidectomy with meticulous exploration of the recurrent laryngeal nerve was found to be a superior method as compared to the subcapsular dissection. KEYWORDS Recurrent Laryngeal Nerve, Subcapsular Dissection, Complete Exploration, Thyroidectomy

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Study on biochemical and radiological profile in children clinically diagnosed as tubercular meningoencephalitis: a prospective study from a tertiary care centre in Rajasthan

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20204040 ◽

2020 ◽

Vol 7 (10) ◽

pp. 1991

Author(s):

Suresh Goyal ◽

Shashibala . ◽

Anuradha Sanadhya ◽

Juhi Mehrotra

Keyword(s):

Controlled Trial ◽

Tertiary Care ◽

Acid Fast Bacillus ◽

Mantoux Test ◽

Communicating Hydrocephalus ◽

Gastric Aspirate ◽

Care Centre ◽

Tertiary Care Centre ◽

Meningeal Enhancement ◽

Cell Counts

Background: Objective of the current study was to assess biochemical profile and neuroimaging findings in children diagnosed with neurotuberculosis in a tertiary care centre in Southern Rajasthan, India.Methods: A prospective randomized controlled trial was conducted in Department of Pediatrics, tertiary care centre in Southern Rajasthan, India from July 2017 to June 2018. Total 110 children of age group of 6 months to 18 years with the diagnosis of tubercular meningoencephalitis (TBME) on the basis of clinical evaluation, cerebrospinal fluid (CSF) examination and neuroimaging were included in the study.Results: Among 110 children included in the study, CSF lymphocytic pleocytosis was seen in all. Majority of children (56.36%) cell counts were in the range of 101-500 cells/µl and mean CSF cell count was 198.09±177.86 per µl. CSF protein ranges from 100 to 400 mg/dl in 68.2% children and 19 children had CSF protein >400 mg/dl with mean of 230.98±167.73 mg/dl. In majority of patients (40%) CSF glucose level was in range of 20-40 mg/dl and in 31.82% children CSF glucose was <20 mg/dl. Mean CSF sugar level was 33.86±18.22 mg/dl. None of them demonstrated acid fast bacillus (AFB) on Ziehl-Neelsen staining of CSF sample. Chest radiographic abnormality was found in 41.82% cases. Mantoux test was positive in 16.36% (18) children admitted with TBME. Common abnormalities noted on neuroimaging were: Communicating hydrocephalus (77.27%), meningeal enhancement (40%), infarction (27.27%), cerebral oedema (11.82%) and 9.09% has tuberculoma on neuroimaging. CSF and gastric aspirate were examined by cartridge based nuleic acid amplification test (CBNAAT) for Mycobacterium Tuberculosis (MTB), among them 5 (4.55%) children had positive in CSF and 16 (14.55%) had gastric aspirate positive for MTB by CBNAAT.Conclusions: Clinical, biochemical and radiological parameters is sufficient enough to diagnose TBME in children.

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