Application of Alginate as Solid Dispersion Carrier to Enhance Solubility of Poorly Soluble Drugs

2016 ◽  
Author(s):  
Yeli Zhang
Keyword(s):  
Solid Dispersion ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

scholarly journals ENHANCEMENT OF THE SOLUBILITY OF FAMOTIDINE SOLID DISPERSION USING NATURAL POLYMER BY SOLVENT EVAPORATION

2021 ◽  
pp. 193-198
Author(s):  
HUSSEIN K. ALKUFI ◽  
ASMAA M. RASHID
Keyword(s):  
Hyaluronic Acid ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Solvent Evaporation ◽  
Water Soluble ◽  
Poorly Soluble Drugs ◽  
Natural Polymer ◽  
Solubility Study ◽  
Poorly Soluble ◽  
Pure Drug

Objective: The aims of the study to enhance solubility and dissolution of famotidine using natural polymer. Solubility study of a drug is one of the contributing factors of its oral bioavailability. The formulation of poorly soluble drugs for oral delivery presents a challenge to the formulation technologists. Methods: The present study has shown that it is possible to raise the solubility for poorly soluble drugs like famotidine, by preparing solid dispersion using natural water-soluble polymer (xyloglucan and hyaluronic acid) as solubilizer through solvent evaporation method. Physical mixture and solid dispersion of famotidine with xyloglucan (XG) or hyaluronic acid in a ratio of 1:1, 1:2, 1:3 were prepared. Solubility study, drug content, dissolution profile and compatibility study were performed for famotidine in solid dispersions XS1, XS2, XS3, HS4, HS5, HS6 as well as in physical mixtures at a ratio 1:1 for both polymer (XG and hyaluronic acid). Results: It was observed that solid dispersions of each drugs showed an increase in dissolution rate in comparison with its pure drug in the ratio of 1:1 (Drug: carrier). It can be concluded that with the care and proper use of xyloglucan, the solubility of drugs poorly soluble can be improved. The prepared solid dispersion showed improvement of drug solubility in all prepared formulas. The best result was obtained with formula XS1 (famotidine: xyloglucan at ratio 1:1) that showed 26 fold increase in solubility compared to the solubility of pure drug. Conclusion: The natural solid dispersion, increased wettability and reduced crystallinity of the drug which leads to improving solubility and dissolution.

Solid dispersion technology as a strategy to improve the bioavailability of poorly soluble drugs

2019 ◽  
Vol 10 (6) ◽  
pp. 363-382 ◽  
Author(s):  
Alicia Graciela Cid ◽  
Analía Simonazzi ◽  
Santiago Daniel Palma ◽  
José María Bermúdez
Keyword(s):  
Solid Dispersion ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Solvent-free direct formulation of poorly-soluble drugs to amorphous solid dispersion via melt-absorption

2017 ◽  
Vol 28 (5) ◽  
pp. 1316-1324 ◽  
Author(s):  
Shou-Cang Shen ◽  
Wai Kiong Ng ◽  
Jun Hu ◽  
Kumaran Letchmanan ◽  
Junwei Ng ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Solvent Free ◽  
Amorphous Solid Dispersion ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Solid Dispersion - a Pragmatic Method to Improve the Bioavailability of Poorly Soluble Drugs

2015 ◽  
pp. 81-100
Author(s):  
Peng Ke ◽  
Sheng Qi ◽  
Gabriele Sadowski ◽  
Defang Ouyang
Keyword(s):  
Solid Dispersion ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Solid Dispersion: An Alternative Technique for Bioavailability Enhancement of Poorly Soluble Drugs

2009 ◽  
Vol 30 (10) ◽  
pp. 1458-1473 ◽  
Author(s):  
Shilpi Sinha ◽  
Sanjula Baboota ◽  
Mushir Ali ◽  
Anil Kumar ◽  
Javed Ali
Keyword(s):  
Solid Dispersion ◽  
Alternative Technique ◽  
Poorly Soluble Drugs ◽  
Bioavailability Enhancement ◽  
Poorly Soluble

scholarly journals Enhancement of solubility of poorly soluble drugs by solid dispersion: An Overview

2017 ◽  
Vol 5 (04) ◽  
pp. 17-23
Author(s):  
Katta Manogna ◽  
P. Nagaveni ◽  
K. Thyagaraju
Keyword(s):  
Solid Dispersion ◽  
Oral Absorption ◽  
Water Soluble ◽  
Poorly Soluble Drugs ◽  
Drug Solubility ◽  
Solid Dosage Forms ◽  
Preparation Methods ◽  
Solid Dosage ◽  
Poorly Soluble ◽  
Poorly Water Soluble

Most of the newly invented chemical drug moieties are poorly water soluble. According to BCS classification, class II and IV drugs are considered as poorly water soluble. So enhancement of oral absorption and bioavailability of solid dosage forms remains a challenge to formulation scientists due to their solubility criteria. Therefore many techniques are being explored to enhance the solubility of poor soluble drugs. Solid dispersion is one of the most important method for enhance the solubility (dissolution rate) and hence oral bioavailability of poorly soluble drugs. In solid dispersion the particle size of drug is reduced or a crystalline pure drug is converted into amorphous form and hence the solubility is increased. Polymer incorporating in solid dispersion technology is usually hydrophilic in nature and also showing compatibility with the drug to enhance the drug solubility. This review mainly discus about solid dispersion, preparation methods, and finally characterization.

scholarly journals The improved dissolution performance of a post processing treated spray-dried crystalline solid dispersion of poorly soluble drugs

2016 ◽  
Vol 42 (11) ◽  
pp. 1800-1812 ◽  
Author(s):  
Siok-Yee Chan ◽  
Seok-Ming Toh ◽  
Nasir Hayat Khan ◽  
Yin-Ying Chung ◽  
Xin-Zi Cheah
Keyword(s):  
Solid Dispersion ◽  
Crystalline Solid ◽  
Poorly Soluble Drugs ◽  
Post Processing ◽  
Poorly Soluble ◽  
Spray Dried
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