PROPHYLAXIS OF VARICEAL BLEEDING IN CIRRHOTIC PATIENTS: EFFICACY AND SAFETY OF ENDOSCOPIC VARICEAL LIGATION IN A TERTIARY CENTRE

2017 ◽  
Author(s):  
Elisa Gravito-Soares
Keyword(s):  
Variceal Bleeding ◽  
Endoscopic Variceal Ligation ◽  
Efficacy And Safety ◽  
Tertiary Centre ◽  
Cirrhotic Patients

EFFICACY OF CARVEDILOL COMBINED WITH ENDOSCOPIC VARICEAL LIGATION IN THE PREVENTION OF RECURRENT VARICEAL BLEEDING IN PATIENTS OF CIRRHOSIS

2016 ◽  
pp. 23-30
Author(s):  
Van Huy Tran ◽  
Thi Ngoc Diep Bui
Keyword(s):  
Side Effects ◽  
Beta Blocker ◽  
Variceal Bleeding ◽  
Poor Prognosis ◽  
Oesophageal Varices ◽  
Endoscopic Variceal Ligation ◽  
Efficacy And Safety ◽  
Orthostatic Hypertension ◽  
Key Words Carvedilol ◽  
Very High

Background: The recurrent variceal bleeding is still very high with a very poor prognosis. The combination of a non-selective beta-blocker and endoscopic variceal ligation (EVL) is still a standard therapy for the prevention, but many patients showed no response to propranolol. Carvedilol is a new, non-selective beta-blocker having intrinsic alpha-blocker activity, but the data about the efficacy and safety of carvedilol is still very limited. This study is aimed at assessing the efficacy and safety of carvedilol combined with EVL in the prevention of recurrent variceal bleeding. Patients and methods: 33 patients having variceal bleeding were enrolled. All patients received carvedilol and were performed the EVL until variceal eradication. All the patients were followed after 9 months. Results: rate of variceal eradication of oesophageal varices was 87.88%; the recurrence rate of variceal bleeding was 12.12% after 9 months. The side effects of carvedilol were rare and not severe, including vertiges, headache, and orthostatic hypertension. Conclusion: Carvedilol combined with EVL appeared as a relatively safe and effective in the prevention of recurrent variceal bleeding in patients of cirrhosis. Key words: carvedilol, variceal bleeding, EVL

Efficacy and safety of terlipressin in cirrhotic patients with variceal bleeding or hepatorenal syndrome

2008 ◽  
Vol 25 (11) ◽  
pp. 1105-1140 ◽  
Author(s):  
Aleksander Krag ◽  
Tine Borup ◽  
Søren Møller ◽  
Flemming Bendtsen
Keyword(s):  
Variceal Bleeding ◽  
Hepatorenal Syndrome ◽  
Efficacy And Safety ◽  
Cirrhotic Patients

scholarly journals Comparison of Endoscopic Variceal Ligation and Nadolol Plus Isosorbide-5-mononitrate in the Prevention of First Variceal Bleeding in Cirrhotic Patients

2006 ◽  
Vol 69 (10) ◽  
pp. 453-460 ◽  
Author(s):  
Huay-Min Wang ◽  
Gin-Ho Lo ◽  
Wen-Chi Chen ◽  
Wei-Lun Tsai ◽  
Hoi-Hung Chan ◽  
...  
Keyword(s):  
Variceal Bleeding ◽  
Endoscopic Variceal Ligation ◽  
Cirrhotic Patients

scholarly journals Endoscopic variceal ligation in prophylaxis of first variceal bleeding in cirrhotic patients with high-risk esophageal varices

Hepatology ◽  
1997 ◽  
Vol 25 (6) ◽  
pp. 1346-1350 ◽  
Author(s):  
C Lay ◽  
Y Tsai ◽  
C Y Teg ◽  
W S Shyu ◽  
W S Guo ◽  
...  
Keyword(s):  
High Risk ◽  
Esophageal Varices ◽  
Variceal Bleeding ◽  
Endoscopic Variceal Ligation ◽  
Cirrhotic Patients

S1475: Endoscopic Variceal Ligation (EVL) Alone Versus Endoscopic Variceal Ligation Plus Propranolol in Variceal Bleeding Prophylaxis in Cirrhotic Patients

2010 ◽  
Vol 71 (5) ◽  
pp. AB171-AB172
Author(s):  
Danielle Bonilha ◽  
Lucianna M. Correia ◽  
Gustavo F. Gomes ◽  
Juliana D. Brito ◽  
Patricia P. Costa ◽  
...  
Keyword(s):  
Variceal Bleeding ◽  
Endoscopic Variceal Ligation ◽  
Bleeding Prophylaxis ◽  
Cirrhotic Patients

scholarly journals The Presence of Ascites Affects the Predictive Value of HVPG on Early Rebleeding in Patients with Cirrhosis

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Chuan Liu ◽  
Ruoyang Shao ◽  
Sining Wang ◽  
Guangchuan Wang ◽  
Lifen Wang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Variceal Bleeding ◽  
Predictive Value ◽  
Characteristic Curve ◽  
Venous Pressure ◽  
Predictive Performance ◽  
Bleeding Risk ◽  
Endoscopic Variceal Ligation ◽  
Acute Variceal Bleeding ◽  
Cirrhotic Patients

Background and Aims. Gastroesophageal variceal bleeding is a serious complication of portal hypertension in cirrhotic patients and could be predicted by hepatic venous pressure gradient (HVPG). However, whether the presence of ascites affects the prognostic value of HVPG for patients with acute variceal bleeding is still unknown. This retrospective study is aimed at investigating the influence of ascites on predictive performance of HVPG for early rebleeding in cirrhotic patients with acute variceal bleeding. Methods. In this retrospective study, a total of 148 patients with cirrhosis hospitalized for acute variceal bleeding who underwent HVPG measurement and endoscopic variceal ligation (EVL) for the prevention of rebleeding were included. The receiver operating characteristic curve (ROC) and logistical regression method were employed to analyze the predictive performance of HVPG for early rebleeding. The locally weighted scatterplot smoothing approach was adopted to assess the monotonicity between bleeding risk and HVPG. Results. A significantly higher HVPG level was observed in patients with early rebleeding compared to patients without rebleeding in the nonascites cohort. When using HVPG to predict early rebleeding, there was a lower area under curve in the ascites cohort compared to the nonascites cohort. HVPG was recognized as a risk factor for early rebleeding by a logistic regression model only in the nonascites cohort. An overall monotonicity in the trend of change in HVPG and risk for early rebleeding was observed in the nonascites cohort solely. Conclusion. The predictive value of HVPG for early rebleeding in patients with cirrhosis that developed acute variceal bleeding is hindered by the presence of ascites.

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