Effect of periodontal treatment on serum levels of carbamylated protein and neutrophil extracellular trap in patients with rheumatoid arthritis

2018 ◽  
Author(s):  
Chihiro Kaneko
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Levels ◽  
Periodontal Treatment ◽  
Neutrophil Extracellular Trap ◽  
Extracellular Trap

scholarly journals A2.8 Enhanced Neutrophil Extracellular Trap Formation in Rheumatoid Arthritis Patients is Correlated with High Levels of Rheumatoid Factor (RF)

2013 ◽  
Vol 72 (Suppl 1) ◽  
pp. A7.1-A7
Author(s):  
Garyfalia Papadaki ◽  
Christiana Choulaki ◽  
George Bertsias ◽  
Ioannis Mitroulis ◽  
Panayotis Verginis ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Neutrophil Extracellular Trap ◽  
Trap Formation ◽  
Extracellular Trap

scholarly journals RB137 recognizes LL37 in neutrophil-extracellular trap-like (NET) structures in systemic lupus erythematosus and rheumatoid arthritis inflamed tissues by immunofluorescence in histological sections

2020 ◽  
Vol 3 (4) ◽  
pp. e235
Author(s):  
Roberto Lande ◽  
Stefano Alivernini ◽  
Barbara Tolusso ◽  
Francesca Spadaro ◽  
Mario Falchi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Neutrophil Extracellular Trap ◽  
Human Tissues ◽  
Systemic Lupus ◽  
Native Form ◽  
Recombinant Monoclonal Antibody ◽  
Health And Disease ◽  
Extracellular Trap

Besides being a natural antibiotic, the human cathelicidin LL37, produced by epithelial cells and neutrophils, is an important immune-modulator. LL37 alone, or in complex with DNA, can activate inflammatory pathways in psoriasis, Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). In this work, we describe the capacity of the recombinant monoclonal antibody RB137, previously shown to specifically recognize LL37 in its native form by ELISA, to detect LL37 by immunofluorescence in human tissues derived from SLE and RA patients. In these tissues, LL37 decorates DNA filaments resembling neutrophil-extracellular-trap (NET) structures. This antibody represents a valuable tool to detect the presence, the native state and the exact localization of LL37 in human tissues in health and disease.

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