The impact of the new WHO classification of tumours of the thyroid gland on the frequency of particular thyroid tumours diagnoses - the single institution experience

2018 ◽  
Author(s):  
Dariusz Lange ◽  
Agata Stanek-Widera
Keyword(s):  
Thyroid Gland ◽  
Who Classification ◽  
Single Institution ◽  
The Impact

scholarly journals The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs

2016 ◽  
Vol 11 (6) ◽  
pp. 862-872 ◽  
Author(s):  
Patrick Micke ◽  
Johanna Sofia Margareta Mattsson ◽  
Dijana Djureinovic ◽  
Björn Nodin ◽  
Karin Jirström ◽  
...  
Keyword(s):  
Who Classification ◽  
Histological Classification ◽  
Fourth Edition ◽  
Lung Tumours ◽  
The Impact

scholarly journals PUB006 Impact of the New WHO Classification of Thymic Tumors: Cross-Validation of the Prognostic Value in a Single Institution Cohort

2017 ◽  
Vol 12 (1) ◽  
pp. S1448-S1449
Author(s):  
Mohamed Kamel ◽  
Navneet Narula ◽  
Jeffrey Port ◽  
Brendon Stiles ◽  
Nasser Altorki
Keyword(s):  
Prognostic Value ◽  
Who Classification ◽  
Cross Validation ◽  
Single Institution ◽  
Thymic Tumors

scholarly journals Understanding the New WHO Classification of Lymphoid Malignancies: Why It's Important and How It Will Affect Practice

2017 ◽  
pp. 535-546
Author(s):  
Elaine S. Jaffe ◽  
Paul M. Barr ◽  
Sonali M. Smith
Keyword(s):  
Who Classification ◽  
World Health ◽  
Future Research ◽  
Lymphoid Malignancy ◽  
Lymphoid Malignancies ◽  
Clinical Investigations ◽  
Health Organization ◽  
The Impact ◽  
New Framework

Improved delineation of lymphoid malignancy biology has prompted refinement of the 2008 World Health Organization (WHO) classification of hematopoietic and lymphoid tumors with a new framework introduced in 2016. This knowledge has provided valuable insights regarding management. Early clonal proliferations have been set apart given their limited potential for malignant dissemination. Increasing knowledge of molecular drivers of aggressive lymphomas has allowed subclassification and opportunity for clinical investigations to personalize therapy. New insights into T-cell pathophysiology has allowed grouping based on shared molecular and cellular features. This article will summarize the key changes in terms of diagnosis and histopathologic definitions, the impact of these changes on clinical management, and the challenges of future research in this field.

scholarly journals Transitioning to Molecular Diagnostics in Pediatric High Grade Glioma: Experiences with the 2016 WHO Classification of CNS Tumors

2021 ◽  
Author(s):  
Joshua Baugh ◽  
Gerrit H Gielen ◽  
Dannis G van Vuurden ◽  
Sophie E M Veldhuijzen van Zanten ◽  
Darren Hargrave ◽  
...  
Keyword(s):  
Molecular Diagnostics ◽  
Who Classification ◽  
High Grade Glioma ◽  
Molecular Diagnostic ◽  
Daily Routine ◽  
High Grade ◽  
The Impact ◽  
Very High ◽  
Pediatric High Grade Glioma

Abstract Background Pediatric neuro-oncology was profoundly changed in the wake of the 2016 revision of the WHO Classification of Tumors of the Central Nervous System. Practitioners were challenged to quickly adapt to a system of tumor classification redefined by molecular diagnostics. Methods We designed a 22 question survey studying the impact of the revised WHO classification on pediatric high-grade glioma. The survey collected basic demographics, general attitudes, issues encountered, and opinions on pediatric subtypes. Participant answers were analyzed along socioeconomic lines utilizing the human development index (HDI) of the United Nations and membership in the group of seven (G7) world economic forum. Results 465 participants from 53 countries were included, 187 pediatric neurooncologists (40%), 160 neuropathologists (34%), and 118 other experts (26%). When asked about pediatric high grade glioma entities, participants from very high development countries preferred treating a patient based on genetic findings. Participants from high and medium development countries indicated using traditional histology and tumor location as mainstays for therapeutic decisions. Non-G7 countries tended to regard the introduction of molecularly characterized tumor entities as a problem for daily routine due to lack of resources. Conclusions Our findings demonstrate an overall greater reliance and favorability to molecular diagnostics among very high development countries. A disparity in resources and access to molecular diagnostics has left some centers unable to classify pediatric high-grade glioma per the WHO classification. The forthcoming edition should strain to abate disparities in molecular diagnostic availability and work towards universal adaptation.

scholarly journals NPM1-mutated acute myeloid leukemia: from bench to bedside

Blood ◽  
2020 ◽  
Vol 136 (15) ◽  
pp. 1707-1721 ◽  
Author(s):  
Brunangelo Falini ◽  
Lorenzo Brunetti ◽  
Paolo Sportoletti ◽  
Maria Paola Martelli
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Who Classification ◽  
Hox Genes ◽  
Residual Disease ◽  
World Health ◽  
Disease Assessment ◽  
The Impact ◽  
Acute Myeloid

Abstract The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations represent the most common genetic lesion in adult acute myeloid leukemia (AML; about one third of cases), and they act deterministically to cause the aberrant cytoplasmic delocalization of NPM1 mutants. Because of its unique features, NPM1-mutated AML is recognized as a distinct entity in the 2017 World Health Organization (WHO) classification of hematopoietic neoplasms. Here, we focus on recently identified functions of wild-type NPM1 in the nucleolus and address new biological and clinical issues related to NPM1-mutated AML. The relevance of the cooperation between NPM1 and other mutations in driving AML with different outcomes is presented. We also discuss the importance of eradicating NPM1-mutated clones to achieve AML cure and the impact of preleukemic clonal hematopoiesis persistence in predisposing to second AML. The contribution of HOX genes’ expression to the development of NPM1-mutated AML is also highlighted. Clinically, yet unsolved diagnostic issues in the 2017 WHO classification of myeloid neoplasms and the importance of NPM1 mutations in defining the framework of European LeukemiaNet genetic-based risk stratification are discussed. Finally, we address the value and limits of NPM1-based measurable residual disease assessment for treatment guidance and present the results of promising preclinical studies with XPO1 and menin-MLL inhibitors.

ON THE CLASSIFICATION OF DIGITAL TECHNOLOGIES IN CIVIL PROCESS

2019 ◽  
pp. 27-35
Author(s):  
Alexandr Neznamov
Keyword(s):  
Information Processing ◽  
Scientific Community ◽  
Digital Technologies ◽  
Significant Feature ◽  
Legal Proceedings ◽  
Civil Process ◽  
Civil Proceedings ◽  
Processing Information ◽  
The Impact

Digital technologies are no longer the future but are the present of civil proceedings. That is why any research in this direction seems to be relevant. At the same time, some of the fundamental problems remain unattended by the scientific community. One of these problems is the problem of classification of digital technologies in civil proceedings. On the basis of instrumental and genetic approaches to the understanding of digital technologies, it is concluded that their most significant feature is the ability to mediate the interaction of participants in legal proceedings with information; their differentiating feature is the function performed by a particular technology in the interaction with information. On this basis, it is proposed to distinguish the following groups of digital technologies in civil proceedings: a) technologies of recording, storing and displaying (reproducing) information, b) technologies of transferring information, c) technologies of processing information. A brief description is given to each of the groups. Presented classification could serve as a basis for a more systematic discussion of the impact of digital technologies on the essence of civil proceedings. Particularly, it is pointed out that issues of recording, storing, reproducing and transferring information are traditionally more «technological» for civil process, while issues of information processing are more conceptual.

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