The prevention of cerebral palsy in preterm infants – the potential role of magnesium sulfate

2019 ◽  
Vol 4 (67) ◽  
pp. 180
Author(s):  
Adelina Staicu ◽  
Adela Hanga ◽  
Ioana C. Rotar ◽  
Gabriela C. Zaharie ◽  
Daniel Mureşan
Keyword(s):  
Cerebral Palsy ◽  
Magnesium Sulfate ◽  
Preterm Infants ◽  
Potential Role

scholarly journals Targeting Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension (BPD-PH): Potential Role of the FGF Signaling Pathway in the Development of the Pulmonary Vascular System

Cells ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1875
Author(s):  
Cho-Ming Chao ◽  
Lei Chong ◽  
Xuran Chu ◽  
Amit Shrestha ◽  
Judith Behnke ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Signaling Pathway ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Potential Role ◽  
Vascular System ◽  
Point Of View ◽  
Pulmonary Vasculature ◽  
Curative Therapy

More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH), leading to a significant increase in total morbidity and mortality. Until today, there is no curative therapy for both BPD and BPD-PH available. It has become increasingly evident that growth factors are playing a central role in normal and pathologic development of the pulmonary vasculature. Thus, this review aims to summarize the recent evidence in our understanding of BPD-PH from a basic scientific point of view, focusing on the potential role of Fibroblast Growth Factor (FGF)/FGF10 signaling pathway contributing to disease development, progression and resolution.

Magnesium sulfate therapy for the prevention of cerebral palsy in preterm infants: a decision-analytic and economic analysis

2011 ◽  
Vol 205 (6) ◽  
pp. 542.e1-542.e7 ◽  
Author(s):  
Alison G. Cahill ◽  
Anthony O. Odibo ◽  
Molly J. Stout ◽  
William A. Grobman ◽  
George A. Macones ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Economic Analysis ◽  
Magnesium Sulfate ◽  
Preterm Infants

Response to ‘Classification of cerebral palsy and potential role of video recording’

2018 ◽  
Vol 22 (1) ◽  
pp. 211-212
Author(s):  
Hendriekje Eggink ◽  
Daan Kremer ◽  
Marina A.J. Tijssen
Keyword(s):  
Cerebral Palsy ◽  
Potential Role ◽  
Video Recording

Magnesium Sulfate for the Prevention of Cerebral Palsy

2021 ◽  
pp. 54-59
Author(s):  
Laura Smith ◽  
Blair J. Wylie
Keyword(s):  
At Risk ◽  
Cerebral Palsy ◽  
Preterm Birth ◽  
Magnesium Sulfate ◽  
Infant Death ◽  
Study Participant ◽  
Neurodevelopmental Outcomes ◽  
Participant Characteristics ◽  
Study Intervention

This article provides a summary of a landmark study in the area of preterm birth and neurodevelopmental outcomes. The researchers ask the question: Does administration of magnesium sulfate to women at risk for preterm birth reduce the risk of cerebral palsy? Starting with that question, this article describes the basics of the study including funding, study participant characteristics, study design, study intervention, endpoints, results, and criticism. The article briefly reviews other relevant studies and explores guidelines related to the role of magnesium in preterm patients. The BEAM trial did not demonstrate improvement in their combined primary outcome of stillbirth and infant death with use of antenatal magnesium sulfate; however, the work contributed to the literature with further evidence that antenatal magnesium sulfate can reduce the rate of cerebral palsy among surviving infants.

Does antenatal magnesium sulfate prevent cerebral palsy in preterm infants? The final trial?

2012 ◽  
Vol 91 (11) ◽  
pp. 1346-1347 ◽  
Author(s):  
LENE DRASBEK HUUSOM ◽  
JESPER BROK ◽  
HANNE K. HEGAARD ◽  
OLE PRYDS ◽  
NIELS JOERGEN SECHER
Keyword(s):  
Cerebral Palsy ◽  
Magnesium Sulfate ◽  
Preterm Infants
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