scholarly journals Early Detection of Mild Cognitive Impairment, Dementia and Alzheimer’s Using Qeeg

2015 ◽  
Vol 3 (1) ◽  
pp. 149 ◽  
Author(s):  
Norsiah Fauzan ◽  
Nur Hurunain Amran
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Detection ◽  
Resting State ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Temporal Region ◽  
Healthy Elderly ◽  
Motor Region ◽  
State Examination

This article reports the biomarkers of the Mild Cognitive Impairment (MCI) among the elderly group aged around 60 -75 years old by analyzing the EEG signals recorded by using the quantitative electroencephalograph (qEEG). There is growing evidence that EEG analysis in resting state condition are useful in early detection of neural signatures of Alzheimer’s and dementia. EEG findings and analysis shows potential of discriminating MCI, Alzheimer’s and dementia. In this research, the purpose is to 1) develop the indexes for each of the EEG bands and sub-bands such as delta (1.5 – 3.5 Hz), theta (3.3 – 7.5 Hz), alpha ( 8 – 12 Hz), beta 1 (15 – 18 Hz) and beta 2 (22 – 30 Hz); 2) provide reference for early diagnosis; 3) extract and analyze the brainwave pattern of MCI and cognitively healthy group. This study involved 19 channel resting state EEG from a total of 30 subjects, 18 diagnosed as having MCI and 12 cognitively healthy elderly with criteria for inclusion if the mini mental state examination (MMSE) score is more than or equal to 28, based on the age and educational level. Development of qEEG index started by decomposition of EEG by performing Fourier analysis, averaging and normalizing the value from the 19 channels to obtain the z-score. Findings showed promise of utility in early detection of Alzheimer’s. Notably, 1) Increases in delta/ theta posterior temporal and prefrontal area i.e., H(6.64) vs. MCI(26.29); beta temporal region, 2) Decreases in alpha at sensory motor region i.e., H(0.27) vs. MCI(0.23).

Early Detection of Mild Cognitive Impairment, Dementia and Alzheimer’s Using Qeeg

2015 ◽  
Vol 1 (3) ◽  
pp. 149
Author(s):  
Norsiah Fauzan ◽  
Nur Hurunain Amran
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Detection ◽  
Resting State ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Temporal Region ◽  
Healthy Elderly ◽  
Motor Region ◽  
State Examination

This article reports the biomarkers of the Mild Cognitive Impairment (MCI) among the elderly group aged around 60 -75 years old by analyzing the EEG signals recorded by using the quantitative electroencephalograph (qEEG). There is growing evidence that EEG analysis in resting state condition are useful in early detection of neural signatures of Alzheimer’s and dementia. EEG findings and analysis shows potential of discriminating MCI, Alzheimer’s and dementia. In this research, the purpose is to 1) develop the indexes for each of the EEG bands and sub-bands such as delta (1.5 – 3.5 Hz), theta (3.3 – 7.5 Hz), alpha ( 8 – 12 Hz), beta 1 (15 – 18 Hz) and beta 2 (22 – 30 Hz); 2) provide reference for early diagnosis; 3) extract and analyze the brainwave pattern of MCI and cognitively healthy group. This study involved 19 channel resting state EEG from a total of 30 subjects, 18 diagnosed as having MCI and 12 cognitively healthy elderly with criteria for inclusion if the mini mental state examination (MMSE) score is more than or equal to 28, based on the age and educational level. Development of qEEG index started by decomposition of EEG by performing Fourier analysis, averaging and normalizing the value from the 19 channels to obtain the z-score. Findings showed promise of utility in early detection of Alzheimer’s. Notably, 1) Increases in delta/ theta posterior temporal and prefrontal area i.e., H(6.64) vs. MCI(26.29); beta temporal region, 2) Decreases in alpha at sensory motor region i.e., H(0.27) vs. MCI(0.23).

Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI)

2021 ◽  
Vol 2021 (7) ◽  
Author(s):  
Ingrid Arevalo-Rodriguez ◽  
Nadja Smailagic ◽  
Marta Roqué-Figuls ◽  
Agustín Ciapponi ◽  
Erick Sanchez-Perez ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Detection ◽  
Mental State ◽  
Mini Mental State Examination ◽  
State Examination

P2-149: The Mini-Mental State Examination gradient in community healthy elderly subjects, mild cognitive impairment and mild dementia

2010 ◽  
Vol 6 ◽  
pp. S357-S357
Author(s):  
Lívia G. Rodrigues ◽  
Ana Luiza Camozzato ◽  
Renata Kochhann ◽  
Claudia Godinho ◽  
Maria Otilia Cerveira ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Elderly Subjects ◽  
Mild Dementia ◽  
Healthy Elderly ◽  
State Examination ◽  
Healthy Elderly Subjects

scholarly journals Assessment for apraxia in Mild Cognitive Impairment and Alzheimer's disease

2015 ◽  
Vol 9 (1) ◽  
pp. 71-75 ◽  
Author(s):  
Mirela Ward ◽  
Juliana F. Cecato ◽  
Ivan Aprahamian ◽  
José Eduardo Martinelli
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mini Mental State Examination ◽  
Average Score ◽  
Clock Drawing Test ◽  
Healthy Elderly ◽  
Drawing Test ◽  
State Examination

OBJECTIVE: To evaluate apraxia in healthy elderly and in patients diagnosed with Alzheimer's disease (AD) and Mild cognitive impairment (MCI). METHODS: We evaluated 136 subjects with an average age of 75.74 years (minimum 60 years old, maximum 92 years old) and average schooling of 9 years (minimum of 7 and a maximum of 12 years), using the Mini-Mental State examination (MMSE), Cambridge Cognitive Examination (CAMCOG) and the Clock Drawing Test. For the analysis of the presence of apraxia, eight subitems from the CAMCOG were selected: the drawings of the pentagon, spiral, house, clock; and the tasks of putting a piece of paper in an envelope; the correct one hand waiving "Goodbye" movements; paper cutting using scissors; and brushing teeth. RESULTS: Elder controls had an average score of 11.51, compared to MCI (11.13), and AD patients, whose average apraxia test scores were the lowest (10.23). Apraxia scores proved able to differentiate the three groups studied (p=0.001). In addition, a negative correlation was observed between apraxia and MMSE scores. CONCLUSION: We conclude that testing for the presence of apraxia is important in the evaluation of patients with cognitive impairments and may help to differentiate elderly controls, MCI and AD.

scholarly journals Combining functional scales and cognitive tests in screening for mild cognitive impairment at a university-based memory clinic in Brazil

2008 ◽  
Vol 30 (4) ◽  
pp. 346-349 ◽  
Author(s):  
Izabella Dutra de Abreu ◽  
Paula Villela Nunes ◽  
Breno Satler Diniz ◽  
Orestes Vicente Forlenza
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Diagnostic Accuracy ◽  
Cognitive Decline ◽  
Mental State ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Elderly Subjects ◽  
Cognitive State ◽  
State Examination

OBJECTIVE: To determine the diagnostic accuracy of the Mini-Mental State Examination combined to the Informant Questionnaire on Cognitive Decline in the Elderly for the identification of mild cognitive impairment. METHOD: 191 elderly subjects were assessed with the Mini-Mental State Examination, and their informants were assessed with the Informant Questionnaire on Cognitive Decline in the Elderly. Subjects were divided into three groups according to their cognitive state (controls: n = 67, mild cognitive impairment: n = 65 and dementia: n = 59), which was ascertained by clinical and neuropsychological evaluation. The diagnostic accuracy of each test in the discrimination of diagnostic groups (mild cognitive impairment vs. controls, mild cognitive impairment vs. dementia and dementia vs. controls) was examined with the aid of ROC curves. We additionally verified if the combination of both tests would increase diagnostic accuracy for mild cognitive impairment and control identification. RESULTS: The combination of the Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline in the Elderly scores did not increase the Mini-Mental State Examination diagnostic accuracy in the identification of patients with mild cognitive impairment. CONCLUSIONS: The present data do not warrant the combination of the Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline in the Elderly as a sufficient diagnostic tool in the diagnostic screening for mild cognitive impairment.

scholarly journals The Effect of Low Impact Aerobic Exercise on Elderly with Dementia Cognitive Function

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Raden Ayu Tanzila ◽  
Sheilla Yonaka Lindri ◽  
Nindia Rahma Putri
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Aerobic Exercise ◽  
Elderly People ◽  
Memory Impairment ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Quasi Experimental ◽  
State Examination

In the elderly population, at least 10% of those over 65 years old and 50% of those over 80 years old experience a decline in cognitive function that varies from a cognitive decline due to normal aging (age-associated memory impairment/AAMI) to a mild cognitive decline (mild cognitive impairment/MCI) and dementia. Dementia is an intellectual disorder that affects the cognitive function, memory, language function, and visuospatial function that causes irreversible changes. Many studies have stated that lifestyle management in the form of increased physical activity has a protective effect on impaired cognitive functions, inhibits cognitive function decline, and even improves cognitive function in healthy elderly people and elderly with mild cognitive impairment to dementia. Low impact aerobic exercise is a physical activity that is useful and suitable for the elderly. This study aimed to determine the effect of low impact aerobic exercise on the cognitive function of elderly people with dementia. This was a quasi-experimental study with one group pretest-posttest method that involved elderly people from Tresna Werdha Teratai Palembang, South Sumatera, Indonesia who were selected based on the inclusion and exclusion criteria (n=38) from December 2018 to February 2019. Treatment provided was a low impact aerobic exercise 3 times a week for 5 weeks. Dementia was then measured before and after treatment using the Mini-mental State Examination (MMSE). The mean values of gymnastics before the treatment and after the treatment were 18.36±4.559 and 19.69±5.724, respectively. A p value of 0.000 was obtained using the Wilcoxon test. In summary, low impact aerobic exercise influences the cognitive function of the elderly with dementia. PENGARUH SENAM AEROBIK LOW IMPACT TERHADAP FUNGSI KOGNITIF USILA DENGAN DEMENSIAPada usia lanjut (usila), sedikitnya 10% dari yang berusia lebih dari 65 tahun dan 50% dari yang berusia lebih dari 80 tahun mengalami penurunan fungsi kognitif yang bervariasi mulai dari penurunan kognitif karena penuaan normal (age-associate memory impairment/AAMI) serta penurunan kognitif ringan (mild cognitive impairment/MCI) hingga demensia. Demensia adalah gangguan intelektual yang meliputi fungsi kognitif, daya ingat, bahasa, fungsi visuospasial, dan bersifat ireversibel. Banyak studi menyatakan bahwa manajemen gaya hidup berupa peningkatan aktivitas fisik mempunyai efek protektif terhadap gangguan fungsi kognitif, menghambat penurunan fungsi kognitif, serta bahkan meningkatkan fungsi kognitif pada usila yang sehat dan usila dengan penurunan fungsi kognitif ringan sampai demensia. Senam aerobik low impact merupakan aktifitas fisik yang bermanfaat dan cocok diberikan kepada usila. Penelitian ini bertujuan mengetahui pengaruh senam aerobik low impact terhadap fungsi kognitif usila dengan demensia. Penelitian ini merupakan studi quasi-experimental dengan metode pretest-posttest one group yang melibatkan usila dari Tresna Werdha Teratai Palembang, Sumatera Selatan, Indonesia yang dipilih berdasar atas kriteria inklusi dan eksklusi (n=38) dari bulan Desember 2018 hingga Februari 2019. Perlakuan yang diberikan berupa senam aerobik low impact 3 kali per minggu selama 5 minggu. Demensia kemudian diukur sebelum dan sesudah perlakuan menggunakan Mini-mental State Examination (MMSE). Nilai rerata senam sebelum perlakuan dan setelah perlakuan adalah 18,36±4,559 dan 19,69±5,724 masing-masing. Nilai p=0,000 didapatkan dengan menggunakan Uji Wilcoxon. Simpulan, senam aerobik low impact memengaruhi fungsi kognitif usila dengan demensia.

scholarly journals Can the MMSE help clinicians predict progression from mild cognitive impairment to dementia?

2015 ◽  
Vol 21 (6) ◽  
pp. 363-366 ◽  
Author(s):  
Alex J. Mitchell
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Risk Prediction ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Case Finding ◽  
Cognitive Test ◽  
Prediction Tool ◽  
State Examination

SummaryThe Mini-Mental State Examination (MMSE) is the most widely used bedside cognitive test. It has previously been shown to be poor as a case-finding tool for both dementia and mild cognitive impairment (MCI). This month's Cochrane Corner review examines whether the MMSE might be used as a risk prediction tool for later dementia in those with established MCI. From 11 studies of modest quality, it appears that the MMSE alone should not be relied on to predict later deterioration in people with MCI. As this is the case, it is likely that only a combination of predictors would be able to accurately predict progression from MCI to dementia.

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