scholarly journals Refractory Thrombocytopenia Associated to Disseminated Histoplasmosis in a Living-Related Renal Transplant Recipient: A Case Report and Review of the Literature

2021 ◽  
Vol 8 (6) ◽  
Author(s):  
Rosario MD ◽  
◽  
Alfredo G-G ◽  
De Jesus AOA ◽  
Jorge AS ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Clinical Characteristics ◽  
Clinical Presentation ◽  
Opportunistic Infections ◽  
Review Of The Literature ◽  
Disseminated Histoplasmosis ◽  
First Case ◽  
Living Related

Opportunistic infections are frequent complications after renal transplantation because of the use of immunosuppressants. Disseminated Histoplasmosis (DH) is one such opportunistic infection, and its clinical presentation varies, which makes its diagnosis a challenge. There is no information regarding DH as a cause of refractory thrombocytopenia in renal transplant recipient (RTR); therefore, we consider this an atypical case, and, because of its clinical characteristics, we have classified it as an Immune Thrombocytopenic Purpura (ITP) induced by histoplasmosis. This is the first case reported in our milieu, and it opens up the possibility for use of intravenous immunoglobulin as a strategic therapy for thrombocytopenia induced by HP in immunosuppressed RTRs.

scholarly journals Severe hypogammaglobulinaemia and opportunistic infections after rituximab therapy in a renal transplant recipient

2009 ◽  
Vol 3 (2) ◽  
pp. 165-167
Author(s):  
A. Kahveci ◽  
E. Asicioglu ◽  
E. Ari ◽  
H. Arikan ◽  
S. Tuglular ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Opportunistic Infections

scholarly journals Disseminated histoplasmosis in a renal transplant recipient – a fatal case report

2011 ◽  
Vol 12 (2) ◽  
pp. 163-165
Author(s):  
Tânia Mara L.B. Araújo ◽  
Geraldo B. Silva Junior ◽  
Orivaldo A. Barbosa ◽  
Rafael S.A. Lima ◽  
Elizabeth F. Daher
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Histoplasma Capsulatum ◽  
Fatal Case ◽  
Tracheal Aspirate ◽  
Respiratory Pattern ◽  
Vasoactive Drugs ◽  
Dimorphic Fungus ◽  
Disseminated Histoplasmosis

Histoplasmosis is an infectious disease caused by the dimorphic fungus Histoplasma capsulatum.. The disseminated form is usually found in immunocompromised patients. A 53 year-old man, renal transplant recipient, was admitted with fever, dyspnea, productive cough, adynamia and weight loss. He was septic, but hemodynamically stable. The tracheal aspirate found intracellular fungi and the peripheral blood exam was compatible with histoplasmosis. The patient presented a progressive worsening of respiratory pattern and needed mechanical ventilation, vasoactive drugs and hemodialysis. A large spectrum antimicrobial therapy was started, including amphotericin B, but the patient died. Keyword: Disseminated histoplasmosis. Kidney transplantation. Immunosuppression DOI: http://dx.doi.org/10.3329/jom.v12i2.7125 JOM 2011; 12(2): 163-165

Liposomal Amphotericin B for Visceral Leishmaniasis in a Kidney Allograft Patient

2002 ◽  
Vol 18 (4) ◽  
pp. 187-191 ◽  
Author(s):  
Marina Valente ◽  
Massimo Marroni ◽  
Claudio Sfara ◽  
Daniela Francisci ◽  
Lisa Malincarne ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Visceral Leishmaniasis ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Liposomal Amphotericin B ◽  
Blood Monocytes ◽  
Lipid Complex ◽  
First Case

Objective To report a case of visceral leishmaniasis treated with liposomal amphotericin B (LAB) after probable failure with amphotericin B lipid complex (ABLC). Case Summary A 62-year-old white renal transplant recipient was admitted for pyrexia, hepato-splenomegaly, and pancytopenia. Leishmania amastigotes were detected from bone marrow aspirate and in circulating blood monocytes and neutrophils. The patient, who weighed 56 kg, received ABLC at a starting dose of 200 mg/d (3.6 mg/kg of body weight per day) for 13 days, achieving a total dose of 2,600 mg (46 mg/kg) without clinical improvement. The patient was switched to 100 mg/d (1.8 mg/kg) of LAB for 10 days, after which a dose of 250 mg (4.5 mg/kg) was repeated on days 17,24,31, and 38. Twenty-four hours after the first dose of LAB, the patient showed an excellent clinical response. On the following days, there was a progressive increase in hemoglobin concentration and leukocyte and platelet counts. Three months later, the patient was asymptomatic. Discussion Although treatment with ABLC appears to be effective for the treatment of Indian patients with visceral leishmaniasis, experience with immunocompromised patients is limited. This is the first case of a renal transplant recipient in which ABLC was used to treat visceral leishmaniasis without remarkable efficacy, but with infusion-related adverse effects perhaps due to the use of higher doses. Conclusions A randomized comparative trial is needed to compare LAB with ABLC in the treatment of visceral leishmaniasis in patients who have received kidney allografts.

Double Endocrine Neoplasia in a Renal Transplant Recipient: Case Report and Review of the Literature

2011 ◽  
Vol 43 (4) ◽  
pp. 1201-1205 ◽  
Author(s):  
A.I. Lo Monte ◽  
V.D. Palumbo ◽  
G. Damiano ◽  
C. Maione ◽  
A.M. Florena ◽  
...  
Keyword(s):  
Case Report ◽  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Review Of The Literature ◽  
Endocrine Neoplasia

Disseminated Histoplasmosis Presenting as Urinary Tract Obstruction in a Renal Transplant Recipient

1994 ◽  
Vol 23 (4) ◽  
pp. 600-604 ◽  
Author(s):  
Keith R. Superdock ◽  
J. Stephen Dummer ◽  
Michael O. Koch ◽  
David M. Gilliam ◽  
David H. Van Buren ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Urinary Tract Obstruction ◽  
Disseminated Histoplasmosis

scholarly journals A 36-Year-Old Renal Transplant Recipient Female with Leg Ulcer: A Case Report and Brief Review

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Ali Monfared ◽  
Eftekhari Hojat ◽  
Seyed Alireza Mesbah ◽  
Abbas Darjani ◽  
Seyyede Zeinab Azimi
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Opportunistic Infections ◽  
Rare Complication ◽  
Organ Transplant ◽  
Transplant Recipients ◽  
Cutaneous Lesions ◽  
Case Presentation ◽  
High Clinical Suspicion

Background. Opportunistic infections are common in organ transplant recipients. After 6 months of transplantation, patients have the highest risk of opportunistic infections such as cryptococcosis. Case Presentation. The report presents the case of a 36-year-old female renal transplant recipient, with complaints of few subcutaneous painful and warm nodules and large, warm, erythematous, nontender plaques on the mildly edematous right leg and ankle. Incisional biopsy of the subcutaneous nodule over the leg showed panniculitis with small- to medium-sized vasculitis associated with round yeast forms, and culture of the fragments revealed C. neoformans var. grubii. Conclusions. This article also reviews in brief the treatment of this rare complication. Reviewing the literature showed that since the cryptococcal cutaneous lesions are often nonspecific, the clinical picture solely is not enough to construct a definite diagnosis and there must be a high clinical suspicion.

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