scholarly journals Development of a Practical Synthesis of the 8-FDC Fragment of OPC-167832

2021 ◽  
Author(s):  
Vijayagopal Gopalsamuthiram ◽  
Dang Ho ◽  
Cheryl Peck ◽  
Vasudevan Natarajan ◽  
Toolika Agrawal ◽  
...  
Keyword(s):  
Column Chromatography ◽  
One Pot ◽  
One Pot Synthesis ◽  
Practical Synthesis

A concise and practical synthesis has been developed to provide the 8-fluoro-5-hydroxy-3,4-diydrocarbostyril (8-FDC) fragment of OPC-167832 in 41 % yield and in > 99 % purity over 4 steps from 3-amino-4-fluorophenol. The key feature of this process is the development of a telescoped one pot synthesis of the quinolone via a chemoselective amidation and easier product isolation without the need for a column chromatography.

ChemInform Abstract: Practical Synthesis of Pinacolborane for One-Pot Synthesis of Unsymmetrical Biaryls via Aromatic C-H Borylation-Cross-Coupling Sequence.

ChemInform ◽  
2008 ◽  
Vol 39 (40) ◽  
Author(s):  
Takao Kikuchi ◽  
Yusuke Nobuta ◽  
Junko Umeda ◽  
Yasunori Yamamoto ◽  
Tatsuo Ishiyama ◽  
...  
Keyword(s):  
Cross Coupling ◽  
One Pot ◽  
One Pot Synthesis ◽  
Practical Synthesis ◽  
Coupling Sequence

scholarly journals Practical synthesis of pinacolborane for one-pot synthesis of unsymmetrical biaryls via aromatic C–H borylation–cross-coupling sequence

Tetrahedron ◽  
2008 ◽  
Vol 64 (22) ◽  
pp. 4967-4971 ◽  
Author(s):  
Takao Kikuchi ◽  
Yusuke Nobuta ◽  
Junko Umeda ◽  
Yasunori Yamamoto ◽  
Tatsuo Ishiyama ◽  
...  
Keyword(s):  
Cross Coupling ◽  
One Pot ◽  
One Pot Synthesis ◽  
Practical Synthesis ◽  
Coupling Sequence

Practical Synthesis of the High-Quality Antitumor Agent KW-2189 from Duocarmycin B2 Using a Facile One-Pot Synthesis of an Intermediate

1998 ◽  
Vol 2 (6) ◽  
pp. 344-350 ◽  
Author(s):  
Masahiko Kinugawa ◽  
Satoru Nagamura ◽  
Akihiko Sakaguchi ◽  
Yoshiaki Masuda ◽  
Hiromitsu Saito ◽  
...  
Keyword(s):  
Antitumor Agent ◽  
High Quality ◽  
One Pot ◽  
One Pot Synthesis ◽  
Practical Synthesis

scholarly journals Mild and Efficient One Pot Synthesis of Imidazolinesand Benzimidazoles from Aldehydes

2007 ◽  
Vol 4 (4) ◽  
pp. 606-610 ◽  
Author(s):  
Rajesh Kumar ◽  
Y. C. Joshi
Keyword(s):  
Ammonium Nitrate ◽  
Column Chromatography ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
High Yields

A series of some imidazolines and benzimidazoles were synthesizedfrom various aldehydes and 1,2-diamines in the presence of ceric(IV)ammonium nitrate (CAN). The title compounds were prepared via one stepsynthesis method. The simplicity of the reaction conditions with shorterreaction time and with out use of column chromatography to get the pureproducts in high yields makes this method more attractive for organic chemists.

ChemInform Abstract: Practical Synthesis of the High-Quality Antitumor Agent KW-2189 from Duocarmycin B2 Using a Facile One-Pot Synthesis of an Intermediate.

ChemInform ◽  
2010 ◽  
Vol 30 (13) ◽  
pp. no-no
Author(s):  
Masahiko Kinugawa ◽  
Satoru Nagamura ◽  
Akihiko Sakaguchi ◽  
Yoshiaki Masuda ◽  
Hiromitsu Saito ◽  
...  
Keyword(s):  
Antitumor Agent ◽  
High Quality ◽  
One Pot ◽  
One Pot Synthesis ◽  
Practical Synthesis

Novel one-pot synthesis of imidazolinones from esters: a concise synthesis of GSK2137305

2020 ◽  
Vol 18 (11) ◽  
pp. 2175-2181 ◽  
Author(s):  
Naiguo Xing ◽  
Jiangkun Huang ◽  
Peng Wang ◽  
Lan Luo ◽  
Shilong Zheng ◽  
...  
Keyword(s):  
One Pot ◽  
One Pot Synthesis ◽  
Practical Synthesis

A new copper-catalyzed one-pot reaction resulted in the practical synthesis of imidazolinones from esters.

scholarly journals Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones – A practical synthesis of monastrol

2009 ◽  
Vol 5 ◽  
Author(s):  
Mukund G Kulkarni ◽  
Sanjay W Chavhan ◽  
Mahadev P Shinde ◽  
Dnyaneshwar D Gaikwad ◽  
Ajit S Borhade ◽  
...  
Keyword(s):  
Potent Inhibitor ◽  
Cost Effective ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Benign Process ◽  
Practical Synthesis ◽  
Kinesin Eg5

A zeolite-catalyzed, simple, one-pot, solvent-free, cost effective, and environmentally benign process for the synthesis of dihydropyrimidones is described. This reaction is scaleable to multigram scale and the catalyst is recyclable. This methodology has resulted in an efficient synthesis of monastrol, a potent inhibitor of kinesin Eg5.

One-Pot Synthesis and Conformational Analysis of 6-Membered Cyclic Iodonium Salts

2020 ◽  
Author(s):  
Lucien Caspers ◽  
Julian Spils ◽  
Mattis Damrath ◽  
Enno Lork ◽  
Boris Nachtsheim
Keyword(s):  
Conformational Analysis ◽  
Bronsted Acids ◽  
One Pot ◽  
Benzyl Alcohols ◽  
Iodonium Salts ◽  
Efficient Approach ◽  
One Pot Synthesis ◽  
Diaryliodonium Salts

In this article we describe an efficient approach for the synthesis of cyclic diaryliodonium salts. The method is based on benzyl alcohols as starting materials and consists of an Friedel-Crafts-arylation/oxidation sequence. Besides a deep optimization, particluar focusing on the choice and ratios of the utilized Bronsted-acids and oxidants, we explore the substrate scope of this transformation. We also discuss an interesting isomerism of cyclic iodonium salts substituted with aliphatic substituents at the bridge head carbon. <br>

Sign in / Sign up

Export Citation Format

Share Document