scholarly journals Design of Potent Mincle Signalling Agonists Based on an Alkyl b- Glucoside Template

2020 ◽  
Author(s):  
DYLAN SMITH ◽  
Yuki Hosono ◽  
Masahiro Nagata ◽  
Sho Yamasaki ◽  
Spencer Williams
Keyword(s):  
Innate Immune ◽  
Immune Receptor ◽  
Innate Immune Receptor ◽  
Structure Activity Relationships ◽  
Trehalose Dimycolate ◽  
Structure Activity

The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure-activity relationships we design simple alkyl 6-<i>O</i>-acyl-b-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.

scholarly journals Design of Potent Mincle Signalling Agonists Based on an Alkyl b- Glucoside Template

2020 ◽  
Author(s):  
DYLAN SMITH ◽  
Yuki Hosono ◽  
Masahiro Nagata ◽  
Sho Yamasaki ◽  
Spencer Williams
Keyword(s):  
Innate Immune ◽  
Immune Receptor ◽  
Innate Immune Receptor ◽  
Structure Activity Relationships ◽  
Trehalose Dimycolate ◽  
Structure Activity

The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure-activity relationships we design simple alkyl 6-<i>O</i>-acyl-b-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.

scholarly journals Protection from Lethal Infection by Adoptive Transfer of CD8 T Cells Genetically Engineered to Express Virus-Specific Innate Immune Receptor

2007 ◽  
Vol 179 (2) ◽  
pp. 1122-1128 ◽  
Author(s):  
Koho Iizuka ◽  
Chigusa Nakajima ◽  
Yoshie-Matsubayashi Iizuka ◽  
Mitsuyo Takase ◽  
Takako Kato ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Adoptive Transfer ◽  
Genetically Engineered ◽  
Innate Immune ◽  
Immune Receptor ◽  
Innate Immune Receptor ◽  
Lethal Infection

Identification and Immunolocalization of the Innate Immune Receptor CD14 in Hypertrophic Adenoids and Tonsils

2010 ◽  
Vol 40 (2) ◽  
pp. 150-159 ◽  
Author(s):  
Avraham Ben-Yaakov ◽  
Bella Maly ◽  
Rani Abu-Ita ◽  
Josef Elidan ◽  
Menachem Gross
Keyword(s):  
Innate Immune ◽  
Immune Receptor ◽  
Innate Immune Receptor

scholarly journals The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis

2008 ◽  
Vol 68 (24) ◽  
pp. 10060-10067 ◽  
Author(s):  
G. Y. Chen ◽  
M. H. Shaw ◽  
G. Redondo ◽  
G. Nunez
Keyword(s):  
Innate Immune ◽  
Immune Receptor ◽  
Innate Immune Receptor

scholarly journals Polymorphisms at the innate immune receptor TLR2 are associated with Borrelia infection in a wild rodent population

2013 ◽  
Vol 280 (1759) ◽  
pp. 20130364 ◽  
Author(s):  
Barbara Tschirren ◽  
Martin Andersson ◽  
Kristin Scherman ◽  
Helena Westerdahl ◽  
Peer R. E. Mittl ◽  
...  
Keyword(s):  
Innate Immune ◽  
Wild Rodent ◽  
Immune Receptor ◽  
Innate Immune Receptor ◽  
Rodent Population

Innate immune receptor signaling, united

2015 ◽  
Vol 8 (368) ◽  
pp. ec64-ec64
Author(s):  
Kristen L. Mueller
Keyword(s):  
Innate Immune ◽  
Receptor Signaling ◽  
Immune Receptor ◽  
Innate Immune Receptor
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