scholarly journals Time-Resolved Decarboxylative Alkyl Coupling Promoted by NADH and Blue Light

2020 ◽  
Author(s):  
Rajdip Chowdhury ◽  
Zhunzhun Yu ◽  
Stefanie V. Kohlhepp ◽  
Xiang Yin ◽  
Abraham Mendoza
Keyword(s):  
Visible Light ◽  
Blue Light ◽  
Biological Systems ◽  
Biological Research ◽  
Coupling Reactions ◽  
Conceptual Basis ◽  
Time Resolved ◽  
Redox Active ◽  
Light Stimuli

<div><div><div><p>Flexible, small and strong alkyl ligations created upon external light stimuli can open new avenues for medicinal and biological research. Herein, we have found that NADH and analogues can drive photo-couplings without auxiliary photocatalysts. The time- resolved alkyl photo-ligation between redox-active carboxylate derivatives and electron-poor olefins displays a surprising moisture and air-tolerance, and unusually high coupling rates in dilute conditions. This work sets the conceptual basis for further biocompatible C-C coupling reactions promoted by visible-light in combination with NADH, the ubiquitous reductant of biological systems.</p></div></div></div>

Time-Resolved Decarboxylative Alkyl Coupling Promoted by NADH and Blue Light

2020 ◽  
Author(s):  
Rajdip Chowdhury ◽  
Zhunzhun Yu ◽  
Stefanie V. Kohlhepp ◽  
Xiang Yin ◽  
Abraham Mendoza
Keyword(s):  
Visible Light ◽  
Blue Light ◽  
Biological Systems ◽  
Biological Research ◽  
Coupling Reactions ◽  
Conceptual Basis ◽  
Time Resolved ◽  
Redox Active ◽  
Light Stimuli

<div><div><div><p>Flexible, small and strong alkyl ligations created upon external light stimuli can open new avenues for medicinal and biological research. Herein, we have found that NADH and analogues can drive photo-couplings without auxiliary photocatalysts. The time- resolved alkyl photo-ligation between redox-active carboxylate derivatives and electron-poor olefins displays a surprising moisture and air-tolerance, and unusually high coupling rates in dilute conditions. This work sets the conceptual basis for further biocompatible C-C coupling reactions promoted by visible-light in combination with NADH, the ubiquitous reductant of biological systems.</p></div></div></div>

Visible-light-induced iodine anion catalyzed decarboxylative/ deaminative C-H alkylation of enamides

2021 ◽  
Author(s):  
Jia-Xin Wang ◽  
Ya-Ting Wang ◽  
Hao Zhang ◽  
Ming-Chen Fu
Keyword(s):  
Amino Acid ◽  
Visible Light ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Active Esters ◽  
Cross Coupling Reactions ◽  
Redox Active ◽  
Iodine Anion

A visible-light-induced iodine anion catalyzed C-H stereoselective alkylation of enamides has been developed. Redox-active esters and Katritzky salts of the amino acid are amenable for decarboxylative/deaminative cross-coupling reactions, delivering various...

scholarly journals Interactions between tetrathiafulvalene units in dimeric structures – the influence of cyclic cores

2015 ◽  
Vol 11 ◽  
pp. 930-948 ◽  
Author(s):  
Huixin Jiang ◽  
Virginia Mazzanti ◽  
Christian R Parker ◽  
Søren Lindbæk Broman ◽  
Jens Heide Wallberg ◽  
...  
Keyword(s):  
Cyclic Voltammetry ◽  
Coupling Reactions ◽  
Double Bonds ◽  
Redox Active ◽  
Metal Catalyzed ◽  
Selection Of

A selection of cyclic and acyclic acetylenic scaffolds bearing two tetrathiafulvalene (TTF) units was prepared by different metal-catalyzed coupling reactions. The bridge separating the two TTF units was systematically changed from linearly conjugated ethyne, butadiyne and tetraethynylethene (trans-substituted) units to a cross-conjugated tetraethynylethene unit, placed in either acyclic or cyclic arrangements. The cyclic structures correspond to so-called radiaannulenes having both endo- and exocyclic double bonds. Interactions between two redox-active TTF units in these molecules were investigated by cyclic voltammetry, UV–vis–NIR and EPR absorption spectroscopical methods of the electrochemically generated oxidized species. The electron-accepting properties of the acetylenic cores were also investigated electrochemically.

Time-resolved analysis of the visible light emitted by laser-produced plasma

2008 ◽  
Vol 163 (4-6) ◽  
pp. 545-550
Author(s):  
G. Privitera ◽  
L. Lanzanò ◽  
A. Scordino ◽  
S. Tudisco ◽  
F. Musumeci ◽  
...  
Keyword(s):  
Visible Light ◽  
Time Resolved ◽  
Laser Produced Plasma

scholarly journals Copper’s rapid ascent in visible-light photoredox catalysis

Science ◽  
2019 ◽  
Vol 364 (6439) ◽  
pp. eaav9713 ◽  
Author(s):  
Asik Hossain ◽  
Aditya Bhattacharyya ◽  
Oliver Reiser
Keyword(s):  
Visible Light ◽  
Organic Dyes ◽  
Low Cost ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Photoredox Catalysis ◽  
Cross Coupling Reactions ◽  
Rapid Ascent ◽  
Catalyzed Reactions ◽  
Metal Catalyzed

Visible-light photoredox catalysis offers a distinct activation mode complementary to thermal transition metal catalyzed reactions. The vast majority of photoredox processes capitalizes on precious metal ruthenium(II) or iridium(III) complexes that serve as single-electron reductants or oxidants in their photoexcited states. As a low-cost alternative, organic dyes are also frequently used but in general suffer from lower photostability. Copper-based photocatalysts are rapidly emerging, offering not only economic and ecological advantages but also otherwise inaccessible inner-sphere mechanisms, which have been successfully applied to challenging transformations. Moreover, the combination of conventional photocatalysts with copper(I) or copper(II) salts has emerged as an efficient dual catalytic system for cross-coupling reactions.

scholarly journals Visible Light-Induced Oxidative N-dealkylation of Alkylamines by a Luminescent Osmium(VI) Nitrido Complex

2021 ◽  
Author(s):  
Tai-Chu Lau ◽  
Jing Xiang ◽  
Peng Ming ◽  
PAN Yi ◽  
Li-Juan Luo ◽  
...  
Keyword(s):  
Dna Repair ◽  
Visible Light ◽  
Biological Systems ◽  
Drug Detoxification

N-Dealkylation of amines by metal oxo intermediates (M=O) is related with drug detoxification and DNA repair in biological systems. In this study, we report the first example of N-dealkylation of...

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