scholarly journals Enzyvitands: evolvable biosynthetic and colorimetric chalices

2021 ◽  
Author(s):  
Thibaud Rossel ◽  
Bing Zhang ◽  
Raphael Gobat
Keyword(s):  
Small Molecules ◽  
Combinatorial Chemistry ◽  
Selective Detection ◽  
X Ray ◽  
Naked Eye ◽  
Coordination Spheres ◽  
Eye Recognition ◽  
Micro Organisms ◽  
Displacement Assays ◽  
Wide Assortment

<div><div><div><p>Designing the perfect sensor is the dream of any chemist. Since decades, a wide diversity of chemosensors targeting analytes has been explored in chemistry. Their chemical optimization is hard and with no guarantee of success. In this context, we propose a fast and easy-to-assemble colorimetric bio-chemical receptor coined Enzyvitand. It consists only of commercial chemicals. It relies on the reunification of combinatorial chemistry, first and second coordination spheres interactions and indicators displacement assays. All harbored within a protein cavity. The sensor is highly modular, cheap and evolvable. Thanks to its solved X-ray structure, we rationally designed it for the naked-eye recognition of dopamine. Hence, our sensor imitates a biological receptor for the recognition of neurotransmitters. Its immediate high versatility and evolvability is valuable for the selective detection of a wide assortment of analytes from small molecules up to micro-organisms. For the future, we anticipate new biotechnological or immunotherapeutic applications of our bio-sensor.</p></div></div></div>

scholarly journals Enzyvitands: versatile evolvable colorimetric chembioreceptors

2021 ◽  
Author(s):  
Thibaud Rossel ◽  
zhang Bing ◽  
Raphael Gobat
Keyword(s):  
Small Molecules ◽  
Complex Samples ◽  
X Ray ◽  
Naked Eye ◽  
Self Assembling ◽  
Coordination Spheres ◽  
Eye Recognition ◽  
Micro Organisms ◽  
Displacement Assays ◽  
Wide Assortment

Designing the perfect sensor is the dream of any chemist. Since decades, a wide diversity of synthetic receptors targeting analytes has been explored in chemistry. Their chemical optimization is hard and with no guarantee of success. In this context, we propose a fast and self assembling colorimetric bio-chemical receptor coined Enzyvitand. It consists only of commercial chemicals. It relies on the reunification of combinatorial chemistry , first and second coordination spheres interactions and indicators displacement assays. All harbored within a protein cavity. The sensor is highly modular, cheap and evolvable. Thanks to its solved X-ray structure, we rationally designed it for the selectiv naked-eye recognition of dopamine over other neutrotransmitters through second coordination sphere. Hence, our sensor imitates a biological receptor for the recognition of neurotransmitters. Finally, it works in complex samples such as urine. Its immediate high versatility and evolvability is valuable for the selective detection of a wide assortment of analytes from small molecules up to micro-organisms. For the future, we anticipate new biotechnological or immunotherapeutic applications of our synthetic oligomer.

scholarly journals Solving an X-Ray Structure of a Bio-Artificial Neurotransmitter Receptor Designed for the Naked-Eye Recognition of Dopamine

2020 ◽  
Author(s):  
Thibaud Rossel ◽  
Bing Zhang ◽  
Raphael Gobat
Keyword(s):  
Chemical Synthesis ◽  
Small Molecules ◽  
Active Site ◽  
Chemical Sensor ◽  
Selective Detection ◽  
Neurotransmitter Receptor ◽  
X Ray ◽  
Naked Eye ◽  
Coordination Spheres ◽  
Eye Recognition

The literature is constellated with a wide variety of chemosensors against a plethora of analytes. This seminal library is used to inspire chemists to improve them using chemical synthesis. However, their optimization via chemical synthesis is a difficult task which takes time without the guarantee of final success.We show here that combinatorial chemistry,the use of first and second coordination spheres and the displacement of indicators united within a protein cavity offers an easy-to-assemble colorimetric bio-chemical sensor. It consists only of commercial chemicals. This colorimetric sensor is highly modular, cheap and evolvable. Its X-ray structure reveals the composition of its active site. This allows to design it rationally for the recognition of dopamine with the naked eye. Our bio-sensor therefore resembles a biological receptor for the recognition of neurotransmitters. Its immediate high adaptability and ability to be evolved can be useful for the selective detection of a wide variety of analytes going from small molecules to microorganisms. This discovery therefore makes it possible to dream of new biotechnological or new immunotherapeutic applications.<br>

scholarly journals Solving an X-Ray Structure of a Bio-Artificial Neurotransmitter Receptor Designed for the Naked-Eye Recognition of Dopamine

2020 ◽  
Author(s):  
Thibaud Rossel ◽  
Bing Zhang ◽  
Raphael Gobat
Keyword(s):  
Chemical Synthesis ◽  
Small Molecules ◽  
Chemical Sensor ◽  
Selective Detection ◽  
Neurotransmitter Receptor ◽  
X Ray ◽  
Naked Eye ◽  
Coordination Spheres ◽  
Eye Recognition ◽  
New Applications

The literature is with a wide variety of against a plethora of . This seminal library is used to inspire chemists to improve them using chemical synthesis. However, their optimization via chemical synthesis is a difficult task which takes time without the guarantee of final success. We show here that chemistry, the use of first and second coordination spheres and the displacement of indicators united within a protein cavity offers an easy-to-assemble bio-chemical sensor. It consists only of commercial chemicals. This sensor is highly modular, cheap and . Its X-ray structure reveals the composition of its active site. This allows to design it rationally for the recognition of dopamine with the naked eye. Our bio-sensor therefore resembles a biological receptor for the recognition of neurotransmitters. Its immediate high adaptability and ability to be evolved can be useful for the selective detection of a wide variety of going from small molecules to microorganisms. This discovery therefore makes it possible to dream of new biotechnological or new applications.

scholarly journals Enzyvitands: evolvable biosynthetic and colorimetric chalices

2020 ◽  
Author(s):  
Thibaud Rossel ◽  
Bing Zhang ◽  
Raphael Gobat
Keyword(s):  
Chemical Synthesis ◽  
Small Molecules ◽  
Active Site ◽  
Chemical Sensor ◽  
Colorimetric Sensor ◽  
Selective Detection ◽  
X Ray ◽  
Naked Eye ◽  
Coordination Spheres

The literature is constellated with a wide variety of chemosensors against a plethora of analytes. This seminal library is used to inspire chemists to improve them using chemical synthesis. However, their optimization via chemical synthesis is a difficult task which takes time without the guarantee of final success.We show here that combinatorial chemistry,the use of first and second coordination spheres and the displacement of indicators united within a protein cavity offers an easy-to-assemble colorimetric bio-chemical sensor. It consists only of commercial chemicals. This colorimetric sensor is highly modular, cheap and evolvable. Its X-ray structure reveals the composition of its active site. This allows to design it rationally for the recognition of dopamine with the naked eye. Our bio-sensor therefore resembles a biological receptor for the recognition of neurotransmitters. Its immediate high adaptability and ability to be evolved can be useful for the selective detection of a wide variety of analytes going from small molecules to microorganisms. This discovery therefore makes it possible to dream of new biotechnological or new immunotherapeutic applications.<br>

scholarly journals Enzyvitands: evolvable biosynthetic and colorimetric chalices

2020 ◽  
Author(s):  
Thibaud Rossel ◽  
Bing Zhang ◽  
Raphael Gobat
Keyword(s):  
Chemical Synthesis ◽  
Small Molecules ◽  
Active Site ◽  
Chemical Sensor ◽  
Colorimetric Sensor ◽  
Selective Detection ◽  
X Ray ◽  
Naked Eye ◽  
Coordination Spheres

The literature is constellated with a wide variety of chemosensors against a plethora of analytes. This seminal library is used to inspire chemists to improve them using chemical synthesis. However, their optimization via chemical synthesis is a difficult task which takes time without the guarantee of final success.We show here that combinatorial chemistry,the use of first and second coordination spheres and the displacement of indicators united within a protein cavity offers an easy-to-assemble colorimetric bio-chemical sensor. It consists only of commercial chemicals. This colorimetric sensor is highly modular, cheap and evolvable. Its X-ray structure reveals the composition of its active site. This allows to design it rationally for the recognition of dopamine with the naked eye. Our bio-sensor therefore resembles a biological receptor for the recognition of neurotransmitters. Its immediate high adaptability and ability to be evolved can be useful for the selective detection of a wide variety of analytes going from small molecules to microorganisms. This discovery therefore makes it possible to dream of new biotechnological or new immunotherapeutic applications.<br>

X-ray Pictures of Micro-organisms

1913 ◽  
Vol 108 (5) ◽  
pp. 115-115
Author(s):  
Alfred Gradenwitz
Keyword(s):  
X Ray ◽  
Micro Organisms

Xenon Trioxide Adducts of O-Donor Ligands; [(CH3)2CO]3XeO3, [(CH3)2SO]3(XeO3)2, (C5H5NO)3(XeO3)2, and [(C6H5)3PO]2XeO3

2018 ◽  
Author(s):  
Katherine Marczenko ◽  
James Goettel ◽  
Gary Schrobilgen
Keyword(s):  
Room Temperature ◽  
Triphenylphosphine Oxide ◽  
Donor Ligands ◽  
Mechanical Shock ◽  
X Ray Diffraction ◽  
X Ray ◽  
Oxygen Coordination ◽  
Xenon Trioxide ◽  
Distorted Octahedra ◽  
Coordination Spheres

Oxygen coordination to the Xe(VI) atom of XeO<sub>3</sub> was observed in its adducts with triphenylphosphine oxide, dimethylsulfoxide, pyridine-N-oxide, and acetone. The crystalline adducts were characterized by low-temperature, single-crystal X-ray diffraction and Raman spectroscopy. Unlike solid XeO<sub>3</sub>, which detonates when mechanically or thermally shocked, the solid [(C<sub>6</sub>H<sub>5</sub>)<sub>3</sub>PO]<sub>2</sub>XeO<sub>3</sub>, [(CH<sub>3</sub>)<sub>2</sub>SO]<sub>3</sub>(XeO<sub>3</sub>)<sub>2</sub>,<sub> </sub>and (C<sub>5</sub>H<sub>5</sub>NO)<sub>3</sub>(XeO<sub>3</sub>)<sub>2</sub> adducts are insensitive to mechanical shock, but undergo rapid deflagration when ignited by a flame. Both [(C<sub>6</sub>H<sub>5</sub>)<sub>3</sub>PO]<sub>2</sub>XeO<sub>3 </sub>and (C<sub>5</sub>H<sub>5</sub>NO)<sub>3</sub>(XeO<sub>3</sub>)<sub>2</sub> are air-stable whereas [(CH<sub>3</sub>)<sub>2</sub>SO]<sub>3</sub>(XeO<sub>3</sub>)<sub>2</sub> slowly decomposes over several days and [(CH<sub>3</sub>)<sub>2</sub>CO]<sub>3</sub>XeO<sub>3</sub> undergoes adduct dissociation at room temperature. The xenon coordination sphere of [(C<sub>6</sub>H<sub>5</sub>)<sub>3</sub>PO]<sub>2</sub>XeO<sub>3</sub> is a distorted square pyramid which provides the first example of a five-coordinate XeO<sub>3</sub> adduct. The xenon coordination spheres of the remaining adducts are distorted octahedra comprised of three Xe---O secondary contacts that are approximately trans to the primary Xe–O bonds of XeO<sub>3</sub>. Quantum-chemical calculations were used to assess the Xe---O adduct bonds, which are predominantly electrostatic σ-hole bonds between the nucleophilic oxygen atoms of the bases and the σ-holes of the xenon atoms.

Adsorption Capacity of Y Zeolite Using Organic Solvents such as Adsorbates

2014 ◽  
Vol 805 ◽  
pp. 641-645
Author(s):  
Ana Paula Araújo ◽  
Aline Cadigena Lima Patrício ◽  
Anna Karoline Freires de Sousa ◽  
Mariaugusta Ferreira Mota ◽  
Meiry Glaúcia Freire Rodrigues
Keyword(s):  
Small Molecules ◽  
Adsorption Capacity ◽  
Selective Adsorption ◽  
X Ray Diffraction ◽  
Y Zeolite ◽  
High Adsorption ◽  
X Ray ◽  
Low Concentrations ◽  
Adsorption Of Nitrogen ◽  
Type Zeolite

The zeolites differ from traditional adsorbents for selective adsorption of small molecules, the high adsorption capacity at low concentrations and affinity for organic compounds and unsaturated polar molecules. In this work a Y-type zeolite was synthesized, characterized by x-ray diffraction, scanning electron microscopy and adsorption of nitrogen and subjected to test adsorption capacity where it was found that the Y zeolite has the potential adsorption capacity compared to other materials being studied and marketed.

Sign in / Sign up

Export Citation Format

Share Document