scholarly journals Analysis of the causes of repeat stenosis of the coronary arteries after elective stenting in patients with stable angina pectoris

2021 ◽  
Vol 93 (1) ◽  
pp. 59-65
Author(s):  
Anastasia Y. Filatova ◽  
Anna K. Osokina ◽  
Alexandra V. Potekhina ◽  
Ivan V. Romasov ◽  
Tatiana I. Kotkina ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Stable Angina ◽  
Coronary Atherosclerosis ◽  
Stable Coronary Artery Disease ◽  
Prognostic Significance ◽  
Coronary Stenting ◽  
Repeat Revascularization ◽  
Atherosclerosis Progression ◽  
Artery Disease ◽  
Repeat Angiography

Aim. Coronary stenting is the evidence-based treatment approach of stable angina. The objective was to determine the incidence of restenosis or atherosclerosis progression which led to the need for coronary angiography according to a single center registry data. Materials and methods. The procedure and clinical data of 3732 (2897 males) consecutive stable coronary artery disease patients undergoing coronary stenting, over five years between March 2010 and September 2014, were subject of this study. Over the next 4 years, 1487 (1173 males) patients were re-evaluated due to angina reoccurrence. 699 patients demonstrated the indications for coronary angiography. Results. The restenosis of the previously stented segment was detected in 84 (12%) cases, the progression of coronary atherosclerosis in 306 (44%), the combination of restenosis and atherosclerosis progression in 63 (9%), and the absence of these complications in 245 (35%) cases. The progression of coronary atherosclerosis was the leading indication for the repeat angiography and revascularization (44 and 58%, respectively); p0.05. The basal level of hsCRP2 mg/l had a prognostic significance for the development of combined event (the restenosis and atherosclerosis progression): AUC 0.65 (0.500.75), OR 3.0 (1.17.9), p0.05. Conclusion. The progression of coronary atherosclerosis was the leading indication for the repeat angiography and repeat revascularization during 2 years after coronary stenting. The hsCRP level 2 mg/l at baseline had a prognostic significance for the development of restenosis in previously stented segment and coronary atherosclerosis progression.

scholarly journals PARAMETERS ASSOCIATED WITH ABSENCE OF SIGNIFICANT CORONARY ATHEROSCLEROSIS BY DATA OF REGISTER OF PROVIDED CORONARY ANGIOGRAPHY

2013 ◽  
Vol 68 (9) ◽  
pp. 27-31
Author(s):  
V. A. Kuznetsov ◽  
E. I. Yaroslavskaya ◽  
E. A. Gorbatenko ◽  
M. V. Varshavchik ◽  
D. V. Krinochkin ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Angiography ◽  
Coronary Stenosis ◽  
Coronary Atherosclerosis ◽  
Smoking Status ◽  
Stable Coronary Artery Disease ◽  
Female Gender ◽  
Principal Factor ◽  
Study Results ◽  
Artery Disease

Aim of the study: the study aimed to reveal the sign of coronary atherosclerosis absence using the factor analysis in patients referred for the coronary angiography. Patients and methods: 9409 patients suspected stable coronary artery disease (CAD) or with confirmed diagnosis of CAD from the «Registry of provided coronary angiography» were included in the study. Results of the study: principal factor described about 59% of the variation and included the burdens of 4 parameters (gender, smoking, significant coronary atherosclerosis and hypothyroidism) and was interpreted as factor of coronary atherosclerosis. Conclusions: it was found that the absence of coronary stenosis was associated with female gender, non-smoking status and hypothyroidism. 

scholarly journals Preprocedural high - sensitivity C-reactive protein (hsCRP) decrease during intensive atorvastatin therapy: the presumable impact on atherosclerosis progression after coronary stenting

2019 ◽  
Vol 91 (9) ◽  
pp. 10-15 ◽  
Author(s):  
A M Shchinova ◽  
G V Shlevkova ◽  
A Yu Filatova ◽  
A V Potekhina ◽  
A K Osokina ◽  
...  
Keyword(s):  
Coronary Atherosclerosis ◽  
Prognostic Significance ◽  
High Sensitivity ◽  
Statin Treatment ◽  
Coronary Stenting ◽  
Hscrp Level ◽  
Atherosclerosis Progression ◽  
Group I ◽  
Atorvastatin Therapy ◽  
One Year

Proinflammatory status is the risk factor for coronary atherosclerosis progression after coronary stenting (CS). Intensive statin treatment is associated with hsCRP concentration decline. Aim: to evaluate prognostic significance of preprocedural hsCRP level reduction with intensive statin regimen for coronary atherosclerosis progression during one year after CS. Materials and methods. We enrolled 102 patients with stable angina who were on list for scheduled CS. Group I (n=37) patients received atorvastatin 80 mg for 7 days before and 3 months after CS with further dose adjustment according to LDL; group II (n=65) patients received atorvastatin 20-40 mg/day for LDL goal achievement. HsCRP level was assessed at baseline, before CS and after 1, 3, 6 and 12 months. Coronary atherosclerosis progression was defined as new ≥50% stenosis or ≥30% increase of ≥20% pre - existing stenosis according to coronary angiography (CA) 1 year after CS. Results. Baseline concentration of hsCRP was comparable: 0.21 (0.13; 0.38) vs. 0.20 (0.1; 0.44) mg/dl in groups I and II, respectively (p>0.05). In group I significant hsCRP level decrease to 0.14 (0.07; 0.32) mg/dl (p

Comorbid conditions - a reason to strengthen antianginai therapy in patients with stable coronary artery disease

2021 ◽  
pp. 49-52
Author(s):  
O. L. Barbarash ◽  
V. V. Kashtalap
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Stable Angina ◽  
Clinical Case ◽  
Stable Coronary Artery Disease ◽  
Mechanisms Of Action ◽  
Functional Class ◽  
Second Line ◽  
Comorbid Conditions ◽  
Artery Disease

In the article on the example of a clinical case approaches to enhancing antianginal therapy of coronary artery disease were discussed. Arguments were given for prescribing preparations of the second line of antianginal agents (thymetazidine) in the patient with stable angina with high functional class and concomitant hypotonia after a complicated COVID-19. The main mechanisms of action of trimetazidine and results of clinical studies were discussed.

Abstract 177: Interleukin 17 and Coronary Stenosis in Patients With Stable Coronary Artery Disease

2015 ◽  
Vol 117 (suppl_1) ◽  
Author(s):  
Dinaldo Oliveira ◽  
Elaine Heide ◽  
Maira Pita ◽  
Danielle A Oliveira ◽  
Ricardo Pontes ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Coronary Stenosis ◽  
Stable Coronary Artery Disease ◽  
Myocardial Revascularization ◽  
Interleukin 17 ◽  
Left Circumflex Artery ◽  
Artery Disease ◽  
Stable Cad

Introduction: The role of the immune and inflammatory pathways in patients with coronary artery disease (CAD) is important but not complete understood. The aim of this study was to evaluate concentrations of the interleukins 17 (IL 17) according to severity of coronary stenosis in patients with stable CAD Hypothesis: There is no association between severity of coronary stenosis and IL 17 in patients with stable CAD. Methods: This is a cross-sectional, prospective, analytical study, conducted from january to september, 2013. We included 40 patients (P) with stable CAD, CCS III or IV, ischemic myocardial scintigraphy, who had not been subjected to any kind of myocardial revascularization and with coronary stenosis ≥ 50% according to current coronary angiography. There were 20 healthy volunteers (C), to take up comparison of concentrations of IL 17. Interleukins were evaluated in serum of patients and after 48 hours of cells in culture with and without stimulus. IL 17 A concentrations were expressed in pg / ml. Coronary stenosis were classified as severe (> 70%) [SS] and intermediate (50 - 69%) [MS] according to coronary angiography. Results: Stenosis ≥ 50% were found in the anterior descending artery in 31 patients, in the left circumflex artery in 19 patients, and in the right coronary artery in 24 patients. No cases of stenosis were observed in the left main. Eighteen patients (45%) had single-artery disease, 8 patients (20%) had two-artery disease, and 14 patients (35%) had multiarterial disease. The comparison between the groups showed: IL 17: Serum: P with SS = 3.91 (3.91 -- 72.27) vs P with MS = 3.91 (3.91 -- 3.91) vs C = 3.91 (3.91 -- 28.8), p = 0.53; culture 48 hours without stimulus: P with SS = 3.91 (3.91 -- 3.91) vs P with MS = 3.91 (3.91 -- 86.8) vs C = 3.91 (3.91 -- 53.3), p = 0.55; culture 48 hours with stimulus: P with SS = 241.8 (3.91 -- 2200) vs P with MS = 217.5 (3.91 -- 1346) vs C = 154.3 (3.91 -- 1353), p = 0.7. Conclusions: There were no differences in concentrations of IL 17 according to severity of coronary stenosis, does not matter in serum or cell in culture. In conclusion, there was no association between severity of coronary stenosis and IL 17 in patients with stable CAD

Prognostic significance of reticulated platelet levels in diabetic patients with stable coronary artery disease

Platelets ◽  
2019 ◽  
Vol 31 (8) ◽  
pp. 1012-1018 ◽  
Author(s):  
Leor Perl ◽  
Yuri Matatov ◽  
Ran Koronowski ◽  
Eli I. Lev ◽  
Alejandro Solodky
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Stable Coronary Artery Disease ◽  
Prognostic Significance ◽  
Diabetic Patients ◽  
Artery Disease
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