scholarly journals Comparative characterizations of patients with hypertensive disease in the mid-1980s and in the 2010s (the patients’ portraits in the context of factor analysis)

2013 ◽  
Vol 10 (1) ◽  
pp. 52-57
Author(s):  
E G Zakharova ◽  
A N Fursov ◽  
N P Potekhin
Keyword(s):  
Factor Analysis ◽  
21St Century ◽  
Antihypertensive Drugs ◽  
Negative Impact ◽  
Angiotensin Receptor Blockers ◽  
Hypertensive Disease ◽  
Early 21St Century ◽  
Group 2 ◽  
Group 1 ◽  
The Early 21St Century

Aim: to study the clinical characteristics of patients with hypertensive disease (HD) in the first decade of the 21st century versus the mid-1980s, by using multivariate statistical methods for the further optimization of therapeutic and diagnostic guidelines. Materials and methods. 234 case histories of patients with HD in the periods 1985 to 1987 (Group 1) and 2010–2012 (Group 2) were analyzed. Factor analysis of 110 signs identified 7 factors or leading symptom complexes. Results. Comparison of HD patients’ portraits in the mid-1980s and the first decade of the 21st century may lead to a number of main conclusions: firstly, HD has undergone certain alternations in the past quarter of a century, which is associated with changes in both the socioeconomic characteristics of society and those in approaches to therapy and with the advent of novel groups of antihypertensive drugs; secondly, the emergence of drugs with a proven nephroprotective effect (angiotensin-converting enzyme inhibitors/angiotensin receptor blockers) resulted in the reduced negative impact of BP on renal functions. Thus, three of the seven factors in Group 1 are directly related to the renal function of patients with HD while Group 2 shows only one factor of systemic and intraglomerular hypertension; thirdly, metabolic disturbances assume great importance in the characterization of Group 2 patients. Metabolic syndrome is typical of them; fourthly, for the patients of the early 21st century, of particular significance is tobacco smoking that is not only a risk factor of cardiovascular diseases in general, but also a factor influencing of the diurnal BP variation that promotes the formation of its particularly unfavorable variants – a night peaker, and finally fifthly, the patients of the early 21st century are characterized by a greater adherence to systemic antihypertensive therapy, which positively affects primarily on the course of the disease, by preventing target organ damage. Conclusion. The findings make it possible to optimize therapeutic and diagnostic efforts in patients with HD and to make more goal-oriented secondary prevention of complications.

scholarly journals Experience in using noliprel and its combination with hormonal replacement therapy in women with postmenopausal hypertensive disease

2005 ◽  
Vol 11 (1) ◽  
pp. 24-28
Author(s):  
Ye. I. Baranova ◽  
O. O. Bolshakova ◽  
N. P. Maslova ◽  
A. A. Katsap ◽  
O. S. Manikhas ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Antihypertensive Therapy ◽  
Negative Impact ◽  
Therapy Group ◽  
Life Quality ◽  
Hormonal Replacement Therapy ◽  
Hypertensive Disease ◽  
Hormonal Replacement ◽  
Group 2 ◽  
Group 1

Objective to evaluate the efficacy and tolerability of fixed low-dose combination of permdopnl and indapamide and its co-administration with hormonal replacement therapy in women with postmenopausal hypertensive disease Materials and methods 63 women with grade 1-2 essential hypertension and postmenopausal syndrome were examined The patients were randomized to receive antihypertensive therapy with noliprel (Group 1) or its combination with hormonal replacement therapy (Group 2) The authors made blood pressure (BP) measurements by the Korotkoff method, 24-hour BP monitoring, echocardiography, studied the lipid spectrum, the plasma levels of glucose, creatinine, potassium, and uric acid, and determined life quality with the modified menopausal index Results A good subjective tolerability of therapy and a decrease in the menopausal index were noted in both groups The efficiency of antihypertensive therapy was 92 7% in Group 1 and 95 2% in Group 2 24-hour BP monitoring showed that the reduction in BP and pressure load was significantly higher in Group 2 than in Group 1 The therapy has no negative impact on metabolic parameters in both groups Conclusion Thus, noliprel is an effective drug in treating postmenopausal women with hypertensive disease Hormonal replacement therapy contributes to the higher antihypertensive effect of noliprel and exerts no effect on its metabolic neutrality

Outlining a grammaticalization path for the Spanish formula en plan (de): A contribution to crosslinguistic pragmatics

Linguistics ◽  
2020 ◽  
Vol 58 (6) ◽  
pp. 1543-1579
Author(s):  
Paula Rodríguez-Abruñeiras
Keyword(s):  
Nineteenth Century ◽  
21St Century ◽  
Discourse Markers ◽  
Contrastive Analysis ◽  
Discourse Marker ◽  
Early 21St Century ◽  
Diachronic Study ◽  
Diachronic Development ◽  
The Early 21St Century

AbstractThis article discusses the diachronic development of the Spanish multifunctional formula en plan (with its variant en plan de, literally ‘in plan (of)’ but usually equivalent to English like). The article has two main aims: firstly, to describe the changes that the formula has undergone since its earliest occurrences as a marker in the nineteenth century up to the early 21st century. The diachronic study evinces a process of grammaticalization in three steps: from noun to clause adverbial and then to discourse marker. Secondly, to conduct a contrastive analysis between en plan (de) and the English markers like and kind of/kinda so as to shed new light on the potential existence of a universal pathway of grammaticalization in the emergence of discourse markers.

Survival of cervical cancer patients in Germany in the early 21st century: A period analysis by age, histology, and stage

2012 ◽  
Vol 51 (7) ◽  
pp. 915-921 ◽  
Author(s):  
Tianhui Chen ◽  
Lina Jansen ◽  
Adam Gondos ◽  
Katharina Emrich ◽  
Bernd Holleczek ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
21St Century ◽  
Period Analysis ◽  
Early 21St Century ◽  
The Early 21St Century

Treatment of leprosy/Hansen's disease in the early 21st century

2009 ◽  
Vol 22 (6) ◽  
pp. 518-537 ◽  
Author(s):  
Sophie M. Worobec
Keyword(s):  
21St Century ◽  
Hansen's Disease ◽  
Early 21St Century ◽  
Hansen’S Disease ◽  
The Early 21St Century

Development and Validation of the Questionnaire of Satisfaction with Perioperative Anesthetic Care for General and Regional Anesthesia in Taiwanese Patients

2011 ◽  
Vol 114 (5) ◽  
pp. 1064-1075 ◽  
Author(s):  
Wui-Chiu Mui ◽  
Chia-Ming Chang ◽  
Kong-Fah Cheng ◽  
Tak-Yu Lee ◽  
Kwok-On Ng ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Patient Satisfaction ◽  
Regional Anesthesia ◽  
Anesthetic Care ◽  
Anesthesia Group ◽  
Confounding Variables ◽  
Group 3 ◽  
Group 2 ◽  
Nomological Validity ◽  
Group 1

Background To fulfill the increasing demand of service quality improvement in recent years, it is imperative to develop a proper instrument to evaluate patient satisfaction with perioperative anesthetic care for many institutes in Taiwan. Methods We used a six-factor 32-item pilot questionnaire developed in our previous study as our starting point in this study. Exploratory factor analysis of the pilot questionnaire for factor structure generation was performed in general anesthesia patients (group 1, n = 320) and resulted in the generation of the Patient Satisfaction with Perioperative Anesthetic Care questionnaire (PSPACq). Confirmatory factor analysis of the PSPACq in general anesthesia (group 2, n = 565) and regional anesthesia (group 3, n = 225) patients was performed for validation and cross-validation of the PSPACq model, respectively. The confounding variables and the patient loyalty effects on PSPACq scores were analyzed to evaluate the nomological validity of the PSPACq. Result Exploratory factor analysis of the pilot questionnaire in group 1 resulted in the development of the PSPACq (a seven-factor 30-item model). The standardized coefficients and indexes for the assessment of fit of the PSPACq model in group 2 (validation) and group 3 (cross-validation) patients revealed a well-fitting model. The results of the loyalty scores and confounding variables support the nomological validity of the PSPACq. Conclusions A valid and reliable questionnaire (PSPACq) with Taiwanese culture characteristics was developed and is suitable for testing of patient satisfaction with perioperative anesthesia care for patients receiving general or regional anesthesia for their surgery.

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