Markers of bone remodeling in patients with surgical menopause undergoing hormone replacement therapy with Divigel

Twenty women with surgical menopause, 40-50 years of age, received hormonal replacement therapy with transdermic preparation Divigel during 24 months. On the background of therapy with Divigel we witnessed normalization of indeces of osteal remodelingconsiderable decrease pyridinoline and deoxypyridinoline, and elevation of alkaline phosphatase. Mineral density of bone tissue in the group of patients with surgical menopause waslowerin comparison with control (p0,01). Divigeltumedto exertprotective influence on the bone tissue inpatients with osteoporosis irrespective о f duration о f surgical menopause by the beginning of therapy.

Psychoemotional disorders in postmenopausal women and methods of their correction

Psycho-emotional disorders in postmenopausal women are caused by interaction of neuroendocrine changes, psychological and social factors. They include anxiety, depression, dissomnia,psychosexual and cognitive dysfunction. Hormonal replacement therapy is widely used in correction of psycho-emotional disturbances in postmenopausal women. Combination of estrogens and antidepressants appears to have good prospects.

Cranial bones mark hormonal disturbances in patients with gonadal dysgenesis

The data on roentgenologic peculiarities o f cranial bones including sella turcica in patients with gonadal dysgenesis are drawn in the paper. Besides that, the authors analyze the changes in size and configuration o f sella turcica under hormonal replacement therapy.

The effectiveness of the drug Divigel in patients with surgical menopause

Twenty women with surgical menopause aged40-50years received parenteral hormonal replacement therapy with estradiol (preparation Divigel) for the period of 12 months. Twenty healthy women formed the control group. The following indeces were estimated during the study: menopausal Kuppermans index, and the leveloffollicle-stimulatinghormone and estradiol in blood serum. Kuppermans index remarkably decreased in the course of treatment (p0,05). Decrease of FSH level was associated with stable growth of estradiol level (p0,05). The absence of manifested side effects and considerable change of body build index, the possibility of choosingthe minimal effective doze individually allow to apply HRT with Divigel more widely.

The state of hemostasis in perimenopause and hormonal replacement therapy

The interruption in the ovarianfunctioning goes along with the disturbances of vascular-trombocyte hemostasis: intravascular trombocyte activation increases, trombocyte micro- and macro-aggregates appear. Cyclic hormonal replacement therapy with Femoston, which contains estradiol and didrogesterone, helps to normalize the trombocytogram. Besides that, the addition of progestagen didrogesterone increases the effect of estradiol on micro circular hemostasia.