Micro- and ultrastructural organization of the common bile duct wall during four-week opioid effect in the experiment

In a previous publication the authors have described some ultrastructural characteristics of granulated cells in the common bile duct of the reindeer. On the basis of the same material, electron microscopic observations on other tissue elements of bile duct wall are now reported. The surface and glandular epithelium were composed of tall columnar epithelial cells with villous structures on the luminal surfaces. The parietal cytoplasmic membranes of epithelial cells were equipped with intercellular desmosomes while intraepithelial globule leucocytes did not form any junctional complex with other cells. Apical cytoplasmic areas of superficial epithelial cells showed electron-dense small bodies possibly consisting of mucinous substances. The goblet and deep glandular cells, on the other hand, contained numerous large mucin granules with less electron-dense matrices. It appears that their secretions are more abundant than those in superficial epithelial cells which obviously are absorptive as their main function. The nuclei and other cytoplasmic organelles showed profiles similar to those in epithelial cells generally. The lumen of the bile ducts was usually empty or contained fine-granular or amorphous material. An unusual feature was the presence of parts of globule leucocytes or even almost whole cells occurring freely in ductal secretions.Elektronimikroskooppinen tutkimus yhteisen sappikäytävän rakenteesta porolla.Abstract in Finnish / Yhteenveto: Aikaisemmassa julkaisussa tekijät kuvasivat poron yhteisen sappikäytävän (ductus hepaticus communis) seinämän jyväsellisten solujen hienorakennetta. Tässä artikkelissa selostetaan saman aineiston perusteella (6 tervettä teurasporoa) elektronimikroskooppisia havaintoja sappikäytäväseinämän muista kudosrakenteista. Sappikäytäväseinämän pinta- ja rauhasepiteeli koostuu korkeista epiteelisoluista. Pinnallisia epiteelisoluja kattavat säännölliset mikrovillukset, ja niillä on vain vähän ilmeisesti limaa sisältäviä jyväsiä solulimassaan. Rau-has- ja pikarisoluissa säännölliset mikrovillukset sen sijaan puuttuvat. Niiden sytoplasman täyttävät runsaat li-mapalloset, joita solut muodostavat hyvin kehittyneessä Golgin laitteessaan erittäen limaa sappikäytävän onte-loon. Erite näkyy hienojyväisenä tai tasa-aineisena seinämiä reunustavana aineena. Poikkeuksellisena havaintona voidaan pitää kerässolujen kerästen tai lähes kokonaisten kerässolujen esiintymistä sappikäytäväon-teloissa mahdollisesti osoituksena solujen vaelluskyvystä. Vaikka epiteelisolut muodostavat lujia solukalvosi-doksia toisiinsa, kerässolut eivät kiinnittyneet muihin soluihin. Ilmeistä on, että pinnallisten epiteelisolujen toiminta on pääasiassa absorptiivista, mutta rauhasepiteelisolut ovat erikoistuneet eritystoimintaan.En elektronmikroskopisk studie av gallgången hos ren.Abstract in Swedish / Sammandrag: Gallgångarnas yt- och körtelepitel bestod av höga epitelceller beklädda med ett regelbundet villusskikt. Intercellulara desmosomer sågs i epitelcellernas parietala cytoplasmamembraner. De intraepiteliala globulara leukocyterna saknade desmosomer eller andra bindningar med nårliggande celler. I de superficiala epitelcellernas apikala cytoplasma fanns elektrontata små kroppar antagligen bestående av mucin. Bägar- och de djupare belagna körtelcellerna inneholl rikligt med stora mucin granulor med ett mindre elektrontatt matrix. Det föreföll som om dessa celler skulle vara sekrerande och de superficiala epitelcellerna absorberande. Kärnen och andra cytoplasmatiska organeller hade egenskaper jamförbara med epitelceller i allmänhet. Gallgången var oftast tom men ibland sågs ett finkornigt amorft material i den. Som en anmarkningsvard observation ansees forekomsten av delar och t.o.m. hela globulara leukocyter i gallgången.

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Balloon Catheter Dilatation of Stenotic Common Bile Duct Anastomoses in the Pig

Acta Radiologica ◽

10.1177/028418518702800123 ◽

1987 ◽

Vol 28 (1) ◽

pp. 115-120

Author(s):

U. Nilsson ◽

L. Ekelund ◽

L.-E. Hammarström ◽

T. Holmin ◽

N. Jonsson

Keyword(s):

Bile Duct ◽

Common Bile Duct ◽

Balloon Dilatation ◽

Thrombus Formation ◽

Balloon Catheter ◽

Percutaneous Transhepatic Cholangiography ◽

Bile Duct Wall ◽

Duct Wall ◽

Catheter Dilatation

Fibrotic stenosing anastomoses of the common bile duct were surgically created in pigs in order to investigate the effects of percutaneous transhepatic balloon catheter dilatation. In a group of 6 animals, not treated with balloon dilatation, percutaneous transhepatic cholangiography and microscopic examination of the stricture were performed 5 to 25 weeks postoperatively. A persistent stenosis and slight to moderate fibrosis of the bile duct wall and peribiliary tissue were observed. In 5 animals the stenotic anastomosis was dilated.4 to 10 weeks postoperatively and this resulted in widening of the stricture and necrosis of the mucosa at the stricture site. Rupture of the fibrotic tissue in the bile duct wall and thrombus formation in the peribiliary veins also occurred in one of these 5 animals. Short-term follow-up in 3 animals 4 to 6 weeks after balloon dilatation showed almost complete fibrotic healing and partial re-stenosis of the anastomoses.

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Immunoglobulin G4–Related Sclerosing Cholangitis Mimicking Hilar Cholangiocarcinoma Diagnosed With Following Bile Duct Resection: Report of a Case

International Surgery ◽

10.9738/intsurg-d-14-00230.1 ◽

2015 ◽

Vol 100 (3) ◽

pp. 480-485 ◽

Cited By ~ 11

Author(s):

Atsushi Miki ◽

Yasunaru Sakuma ◽

Hideyuki Ohzawa ◽

Yukihiro Sanada ◽

Hideki Sasanuma ◽

...

Keyword(s):

Bile Duct ◽

Common Bile Duct ◽

Portal Vein ◽

Sclerosing Cholangitis ◽

Plasma Cells ◽

Intraductal Ultrasonography ◽

Immunoglobulin G4 ◽

Invasive Approach ◽

Bile Duct Wall ◽

The Common

We report a rare case of immunoglobulin G4 (IgG4)–related sclerosing cholangitis without other organ involvement. A 69-year-old-man was referred for the evaluation of jaundice. Computed tomography revealed thickening of the bile duct wall, compressing the right portal vein. Endoscopic retrograde cholangiopancreatography showed a lesion extending from the proximal confluence of the common bile duct to the left and right hepatic ducts. Intraductal ultrasonography showed a bile duct mass invading the portal vein. Hilar bile duct cancer was initially diagnosed and percutaneous transhepatic portal vein embolization was performed, preceding a planned right hepatectomy. Strictures persisted despite steroid therapy. Therefore, partial resection of the common bile duct following choledochojejunostomy was performed. Histologic examination showed diffuse and severe lymphoplasmacytic infiltration, and abundant plasma cells, which stained positive for anti-IgG4 antibody. The final diagnosis was IgG4 sclerosing cholangitis. Types 3 and 4 IgG4 sclerosing cholangitis remains a challenge to differentiate from cholangiocarcinoma. A histopathologic diagnosis obtained with a less invasive approach avoided unnecessary hepatectomy.

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Perforators of common bile duct wall in portal hypertensive biliopathy (with videos)

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2009.03.040 ◽

2009 ◽

Vol 70 (5) ◽

pp. 1041-1043 ◽

Cited By ~ 19

Author(s):

Malay Sharma ◽

Amit Pathak

Keyword(s):

Bile Duct ◽

Common Bile Duct ◽

Bile Duct Wall ◽

Duct Wall

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Spontaneous common bile duct perforation due to choledocolithiasis accompanied with pancreaticobiliary maljunction in an adult: a case report

Surgical Case Reports ◽

10.1186/s40792-021-01290-9 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Risa Sakamoto ◽

Kengo Kai ◽

Masahide Hiyoshi ◽

Naoya Imamura ◽

Koichi Yano ◽

...

Keyword(s):

Case Report ◽

Bile Duct ◽

Common Bile Duct ◽

Emergency Surgery ◽

Postoperative Management ◽

Pancreaticobiliary Maljunction ◽

Retroperitoneal Abscess ◽

Bile Duct Wall ◽

T Tube ◽

Duct Wall

Abstract Background Spontaneous common bile duct (CBD) perforation is an extremely rare disease in adults. We report an adult case of CBD perforation due to choledocolithiasis accompanied with pancreaticobiliary maljunction, which is, to our knowledge, the first such case report based on a search using PubMed. Case presentation A 71-year-old woman with consciousness disorder was transported to the emergency department of another hospital. She was diagnosed as having severe peritonitis with septic shock and transferred to our hospital for emergency surgery. Enhanced computed tomography (CT) revealed supraduodenal CBD dilation similar to a diverticulum and a defect of bile duct wall continuity. Furthermore, CT showed a long common channel of the pancreaticobiliary duct, so she was diagnosed as having spontaneous CBD perforation with pancreaticobiliary maljunction. Emergency surgery was performed that revealed a necrotic diverticulum-like change on the supraduodenal part, and a 2.5 × 1 cm perforation was found on the anterolateral wall of the CBD. Peritoneal lavage was performed, and CBD perforation was resolved with a T-tube. The patient suffered refractory intra-abdominal and retroperitoneal abscess formation and bleeding from the abdominal wall, which required a long period of postoperative management. The T-tube was removed on day 136, and the patient was transferred on day 153. Conclusion The cause of CBD perforation is commonly considered to be increased intraductal pressure or weakness of the bile duct wall. In this case, pancreaticobiliary maljunction may have significantly influenced onset and the postoperative course. This case suggests that early surgical intervention and appropriate drainage are important to ensure survival.

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Painless Obstructive Jaundice Secondary to a Common Bile Duct Abscess: A Delayed Sequela of Cholecystectomy

HPB Surgery ◽

10.1155/2009/628197 ◽

2009 ◽

Vol 2009 ◽

pp. 1-3

Author(s):

Katherine Fairhurst ◽

Andrew Strickland ◽

Franklin H. G. Bridgewater ◽

Guy J. Maddern

Keyword(s):

Bile Duct ◽

Common Bile Duct ◽

Obstructive Jaundice ◽

Clinical Presentation ◽

Open Cholecystectomy ◽

Early Postoperative Period ◽

Unique Case ◽

Bile Duct Wall ◽

Delayed Complications ◽

The Common

Complications related to cholecystectomy are well described. Most occur in the early postoperative period and are recognised either at the time of, or shortly after surgery. Clinical sequelae occurring years following cholecystectomy are rare and infrequently reported. In addition, most delayed complications are related to the continuing presence or new formation of gallstones. In this paper we present a unique case of an abscess of the common bile duct wall, presenting with painless obstructive jaundice more than 30 years following an open cholecystectomy, without the presence of gallstones. The clinical presentation, investigations, and treatment are discussed with a review of other relevant reported cases in the literature.

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