scholarly journals The Effect of Patterned Sound Deprivation upon Auditory Discrimination in Albino Rats

2021 ◽  
Author(s):  
◽  
Robin Fraser Patchett
Keyword(s):  
Discrimination Task ◽  
Prior Experience ◽  
Pattern Discrimination ◽  
Field Testing ◽  
Frequency Discrimination ◽  
Auditory Discrimination ◽  
Sensitive Period ◽  
Albino Rats ◽  
Sprague Dawley ◽  
Auditory Pattern

<p>To test the hypothesis that prior patterned or varied auditory experience was necessary for the development of auditory frequency discrimination and auditory pattern discrimination, groups of sprague-Dawley albino rats were deprived of patterned sound from birth by the novel technique of rearing them in 'white' noise. The sound deprived rats learned a frequency discrimination as easily as controls reared in varied sound conditions, but showed inferior performance on an auditory pattern discrimination task. Supporting experiments showed that the inferiority of varied sound deprived animals on the pattern discrimination task was not likely to have been due to their emotional state at the time of the testing nor to their inferiority in learning to respond in a discrimination task compared with non-deprived controls. Open-field testing showed that the sound deprived subjects did not differ from non-deprived controls in 'emotionality'. The sound deprived rats were not inferior, either, to controls on a complex visual discrimination task. Experiments were also carried out to explore the effect of various durations of patterned sound deprivation and the effect of the deprivation at various times in the life cycle of the rat on auditory pattern discrimination. The results of these experiments favoured an explanation for the effect of varied sound experience which proposed that patterned auditory discrimination development depended, simply, on prior experience with varied sound rather than an explanation which proposed that the effect depended on varied sound experience during a particular sensitive period in the life of the rat. The research involved a total of seven different experiments, the similarities in the findings of which when compared with those of other investigators working in the area of the effects of deprivation of patterned light on visual discriminations were noted. The present experiments support generalizations about the role of prior experience on later behaviour, based largely on experiments in the visual mode, by supplying evidence from another sensory mode.</p>

scholarly journals The Effect of Patterned Sound Deprivation upon Auditory Discrimination in Albino Rats

2021 ◽  
Author(s):  
◽  
Robin Fraser Patchett
Keyword(s):  
Discrimination Task ◽  
Prior Experience ◽  
Pattern Discrimination ◽  
Field Testing ◽  
Frequency Discrimination ◽  
Auditory Discrimination ◽  
Sensitive Period ◽  
Albino Rats ◽  
Sprague Dawley ◽  
Auditory Pattern

<p>To test the hypothesis that prior patterned or varied auditory experience was necessary for the development of auditory frequency discrimination and auditory pattern discrimination, groups of sprague-Dawley albino rats were deprived of patterned sound from birth by the novel technique of rearing them in 'white' noise. The sound deprived rats learned a frequency discrimination as easily as controls reared in varied sound conditions, but showed inferior performance on an auditory pattern discrimination task. Supporting experiments showed that the inferiority of varied sound deprived animals on the pattern discrimination task was not likely to have been due to their emotional state at the time of the testing nor to their inferiority in learning to respond in a discrimination task compared with non-deprived controls. Open-field testing showed that the sound deprived subjects did not differ from non-deprived controls in 'emotionality'. The sound deprived rats were not inferior, either, to controls on a complex visual discrimination task. Experiments were also carried out to explore the effect of various durations of patterned sound deprivation and the effect of the deprivation at various times in the life cycle of the rat on auditory pattern discrimination. The results of these experiments favoured an explanation for the effect of varied sound experience which proposed that patterned auditory discrimination development depended, simply, on prior experience with varied sound rather than an explanation which proposed that the effect depended on varied sound experience during a particular sensitive period in the life of the rat. The research involved a total of seven different experiments, the similarities in the findings of which when compared with those of other investigators working in the area of the effects of deprivation of patterned light on visual discriminations were noted. The present experiments support generalizations about the role of prior experience on later behaviour, based largely on experiments in the visual mode, by supplying evidence from another sensory mode.</p>

Auditory Frequency Discrimination in Patterned-Sound-Naive Albino Rats

1977 ◽  
Vol 44 (1) ◽  
pp. 127-136 ◽  
Author(s):  
Robin F. Patchett
Keyword(s):  
White Noise ◽  
Frequency Discrimination ◽  
Albino Rats ◽  
Sprague Dawley ◽  
Auditory Experience

To test the hypothesis that prior patterned or varied auditory experience was necessary for the development of discrimination of auditory frequency, Sprague-Dawley albino rats were deprived of patterned sound from birth by the technique of rearing them in white noise. The sound-deprived rats learned a frequency discrimination as easily as controls reared in varied sound conditions.

Further Evaluation of a Sensitive Method for Detecting Experimental Brain Lesions

1975 ◽  
Vol 41 (2) ◽  
pp. 407-410 ◽  
Author(s):  
Terry J. Hottman ◽  
Robert E. Sanders ◽  
Christine M. Rinck ◽  
Charles L. Sheridan
Keyword(s):  
Pattern Discrimination ◽  
Brain Lesions ◽  
Extrastriate Cortex ◽  
Albino Rats ◽  
Cortical Lesions ◽  
Sprague Dawley ◽  
Posterior Cortex ◽  
Eyes Open ◽  
Sensitive Method

Small, unilateral cortical lesions were placed in either medial-anterior, lateral-anterior, or posterior cortex of 20 male, Sprague-Dawley, albino rats. In addition, unilateral sham operations were performed on 8 rats from the same stock. All subjects had been trained prior to surgery with diametrically opposed visual habits mediated by opposite cerebral hemispheres. The opposing habits were, insofar as possible, evenly matched prior to surgery. After surgery, lesioned hemispheres, regardless of locus of lesion, were slower in acquiring the habit they mediated, than were unlesioned hemispheres. Further, unlesioned hemispheres dominated in test trials in which subjects chose one of the two cue doors with both eyes open. These findings confirm that the “interocularly conflicting discrimination” baseline detects a role of extrastriate cortex in mediation of pattern discrimination habits. They further indicated that losses occur without regard to the various locations of lesion employed.

Event-related potentials in methamphetamine psychosis during an auditory discrimination task

1993 ◽  
Vol 242 (4) ◽  
pp. 203-208 ◽  
Author(s):  
Akira Iwanami ◽  
Ichiro Suga ◽  
Nobukatsu Kato ◽  
Yoji Nakatani ◽  
Tsuguo Kaneko
Keyword(s):  
Discrimination Task ◽  
Event Related Potentials ◽  
Auditory Discrimination ◽  
Related Potentials

Development of a Pitch Discrimination Screening Test for Preschool Children

2016 ◽  
Vol 27 (04) ◽  
pp. 281-292
Author(s):  
Maria Kulick Abramson ◽  
Peter J. Lloyd
Keyword(s):  
Preschool Children ◽  
Specific Language Impairment ◽  
Normative Data ◽  
Frequency Discrimination ◽  
Auditory Discrimination ◽  
Auditory Memory ◽  
Pitch Discrimination ◽  
Choice Response ◽  
Typically Developing ◽  
Cross Sectional

Background: There is a critical need for tests of auditory discrimination for young children as this skill plays a fundamental role in the development of speaking, prereading, reading, language, and more complex auditory processes. Frequency discrimination is important with regard to basic sensory processing affecting phonological processing, dyslexia, measurements of intelligence, auditory memory, Asperger syndrome, and specific language impairment. Purpose: This study was performed to determine the clinical feasibility of the Pitch Discrimination Test (PDT) to screen the preschool child’s ability to discriminate some of the acoustic demands of speech perception, primarily pitch discrimination, without linguistic content. The PDT used brief speech frequency tones to gather normative data from preschool children aged 3 to 5 yrs. Research Design: A cross-sectional study was used to gather data regarding the pitch discrimination abilities of a sample of typically developing preschool children, between 3 and 5 yrs of age. The PDT consists of ten trials using two pure tones of 100-msec duration each, and was administered in an AA or AB forced-choice response format. Study Sample: Data from 90 typically developing preschool children between the ages of 3 and 5 yrs were used to provide normative data. Data Analysis: Nonparametric Mann–Whitney U-testing was used to examine the effects of age as a continuous variable on pitch discrimination. The Kruskal–Wallis test was used to determine the significance of age on performance on the PDT. Spearman rank was used to determine the correlation of age and performance on the PDT. Results: Pitch discrimination of brief tones improved significantly from age 3 yrs to age 4 yrs, as well as from age 3 yrs to the age 4- and 5-yrs group. Results indicated that between ages 3 and 4 yrs, children’s auditory discrimination of pitch improved on the PDT. The data showed that children can be screened for auditory discrimination of pitch beginning with age 4 yrs. Conclusions: The PDT proved to be a time efficient, feasible tool for a simple form of frequency discrimination screening in the preschool population before the age where other diagnostic tests of auditory processing disorders can be used.

Chronic effect of exercise on liver cholesterol of normal and hypercholesteremic rats

1963 ◽  
Vol 205 (3) ◽  
pp. 453-456 ◽  
Author(s):  
Philip D. Gollnick
Keyword(s):  
Exercise Program ◽  
Normal Diet ◽  
The Other ◽  
Liver Cholesterol ◽  
Albino Rats ◽  
Cholesterol Diet ◽  
Trained Group ◽  
Sprague Dawley ◽  
Cholesterol Accumulation ◽  
Body Weights

Two groups of male albino rats of the Sprague-Dawley strain, with average initial body weights of about 265 g, were trained for 22 weeks on an exercise program of swimming one-half hour daily in water at 35 C. One trained group was fed a normal diet containing 18% casein. The other trained group received an isocaloric diet containing 1% cholesterol which was designed to produce hypercholesteremia. Two nonexercised groups, one fed the normal and the other the 1% cholesterol diet, served as controls. The adrenals and heart ventricles of both trained groups were larger than their respective controls. Exercise had no hypocholesteremic effect on the sera of either trained group. Fat and cholesterol accumulation in the livers of rats fed the 1% cholesterol diet were not affected by training, but training significantly lowered the fat and cholesterol of the livers of the normal rats.

scholarly journals EFFICACY OF TRIDHAM AND 1,2,3,4,6-PENTA-O-GALLOYL-β-D-GLUCOSE IN REVERSING LIPID PEROXIDATION LEVELS AND MITOCHONDRIAL ANTIOXIDANT STATUS IN 7,12-DIMETHYLBENZENEANTHRACENE (DMBA) INDUCED BREAST CANCER IN SPRAGUE-DAWLEY RATS

2016 ◽  
Vol 8 (9) ◽  
pp. 288 ◽  
Author(s):  
Stalin Ramakrishnan ◽  
Karthick Dharmalingam ◽  
Sachidanandham T Panchanatham ◽  
Shanthi Palanivelu
Keyword(s):  
Lipid Peroxidation ◽  
Therapeutic Effect ◽  
Mammary Carcinoma ◽  
Antioxidant Status ◽  
Albino Rats ◽  
Histopathological Analysis ◽  
Sprague Dawley ◽  
Standard Drug ◽  
Gastric Intubation ◽  
Group I

<p><strong>Objective: </strong>To determine the effect of <em>Tridham</em> (TD) and 1,2,3,4,6-penta-O-galloyl-β-d-glucose(PGG) on lipid peroxidation levels and mitochondrial antioxidants status in experimental mammary carcinoma.</p><p><strong>Methods</strong>:<strong> </strong><em>Elaecoarpus ganitrus </em>(fruits), <em>Terminalia chebula </em>(seed coats), <em>Prosopis cineraria </em>(leaves)<em>, </em>adult female albino rats of Sprague-Dawley strain weighing 170–190 g and 7,12-dimethylbenzeneanthracene (DMBA) were used for this study. Group I control rats, Group II rats mammary carcinoma induced with DMBA (25 mg in 1 ml olive oil) by gastric intubation. Group III, IV and V DMBA induced rats were treated with TD (400 mg/kg. b. wt/day), PGG (30 mg/kg. b. wt/day) and standard drug, Cyclophosphamide (30 mg/kg. b. wt/day), respectively for 48 d by gastric intubation. Group VI and VII rats served as TD and PGG treated controls, respectively for 48 d by gastric intubation. At the end of the experimental period, the rats were anaesthetized and sacrificed. Mammary glands were isolated and used for biochemical assays and histopathological evaluation.</p><p><strong>Results: </strong>In rats with cancer, the lipid peroxide levels (LPO) were significantly increased and mitochondrial antioxidant levels were decreased. Treatment with TD and PGG decreased LPO levels and increased mitochondrial antioxidant status in mammary carcinoma bearing rats. Histopathological analysis also confirmed the therapeutic effect of TD and PGG. No significant adverse effect was observed in sole drug treated group of rats.</p><p><strong>Conclusion: </strong>TD and PGG have definite therapeutic effect in experimental mammary carcinoma and inhibit growth of cancer cells by restoring mitochondrial antioxidant status and energy metabolism to normal states.</p>

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