scholarly journals PROTECTIVE EFFECT OF GLYCYRRHIZC ACID AGAINST CARBON TETRACHLORIDE-INDUCED LIVER FIBROSIS IN RATS: ROLE OF INTEGRIN SUBUNIT β LIKE 1 (ITG Β L1)

2019 ◽  
Vol 56 (22-Suppl) ◽  
Author(s):  
Amal Ragab ◽  
Nasr Nasr ◽  
Khalid Kahilo
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Protective Effect ◽  
Integrin Subunit

Protective effect of mixture of Aloe and Silybum on carbon tetrachloride-induced acute hepatotoxicity and liver fibrosis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
YJ Moon ◽  
WC Lee ◽  
SJ Kim ◽  
ST Oh ◽  
EJ Shin ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Protective Effect

scholarly journals Protective Effect of a Mixture of Aloe vera and Silybum marianum Against Carbon Tetrachloride–Induced Acute Hepatotoxicity and Liver Fibrosis

2009 ◽  
Vol 109 (1) ◽  
pp. 119-127 ◽  
Author(s):  
Sung-Hwa Kim ◽  
Ho Jun Cheon ◽  
Nari Yun ◽  
Sun-Tack Oh ◽  
Eunju Shin ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Protective Effect ◽  
Aloe Vera ◽  
Silybum Marianum

Protective effect of a coffee preparation (Nescafe pure®) against carbon tetrachloride-induced liver fibrosis in rats

2010 ◽  
Vol 29 (3) ◽  
pp. 399-405 ◽  
Author(s):  
Hongyang Shi ◽  
Lei Dong ◽  
Yong Zhang ◽  
Yanhua Bai ◽  
Juhui Zhao ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Protective Effect ◽  
Coffee Preparation

Deficiency of BPOZ2 Decreases Liver Fibrosis After Chronic Carbon Tetrachloride Administration in Mice

2015 ◽  
Vol 34 (2) ◽  
pp. 204-210
Author(s):  
Feng Zhang ◽  
Suying Dang ◽  
Runzhe Shu ◽  
Yougui Xiang ◽  
Ying Kuang ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Ubiquitin Ligase ◽  
Adaptor Protein ◽  
Matrix Metalloprotease ◽  
Carbon Tetrachloride Administration ◽  
Broad Complex ◽  
Sustained Activation

Bood POZ containing gene type 2 (BPOZ2), a Broad-Complex, Tramtrack, and Bric a brac domain containing protein, is an adaptor protein for the E3 ubiquitin ligase scaffold protein CUL3. It plays an important role in acute carbon tetrachloride (CCl4)-induced liver injury and regeneration in mice. In this study, we investigated the role of BPOZ2 in the process of liver fibrosis induced by chronic CCl4 treatment. The results indicate that BPOZ2 deficiency decreases sustained activation of hepatic stellate cells, attenuates collagen αI(I) and tissue inhibitor of matrix metalloprotease 1 expression, and decreases liver fibrosis after repeated CCl4 administration. These findings suggest BPOZ2 as a new therapeutic target for the prevention and treatment of hepatic fibrosis in chronic liver disease.

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