Reference values of blood cell counts in the first days of life

10.2741/e295 ◽  
2011 ◽  
Vol E3 (3) ◽  
pp. 871-878 ◽  
Author(s):  
Giovanni Melioli
Keyword(s):  
Blood Cell ◽  
Reference Values ◽  
Cell Counts ◽  
Blood Cell Counts

scholarly journals White blood cell counts, CRP, GGT and LDH in the elderly German population

2019 ◽  
Vol 43 (2) ◽  
pp. 57-65
Author(s):  
Gabriele Röhrig ◽  
Ingrid Becker ◽  
Anna Hagemeier ◽  
Kai Gutensohn ◽  
Thomas Nebe
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Reference Values ◽  
German Population ◽  
Reference Ranges ◽  
Inclusion Criteria ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts ◽  
Glutamyl Transferase

Abstract Background Hematological abnormalities are frequently found in geriatric patients. However, little data is available on reference values for total blood cell counts in older patients. This study is focused on the analysis of reference values for white blood cell counts in aged persons ≥60 years. Methods This was a cross-sectional study of outpatient laboratory data of 2015 from a German countrywide working laboratory company; inclusion criteria: age ≥60 years, parameters evaluated by the laboratory company between 1.1.2015 and 31.12.2015; exclusion criteria: glomerular filtration rate (GFR) <60 mL/min, lack of inclusion criteria; primary objective: mean leukocyte count; secondary objective: mean counts of lymphocytes, eosinophil, neutrophil and basophil leukocytes as well as platelets, C-reactive protein (CRP), γ-glutamyl transferase (GGT) and lactate dehydrogenase (LDH) in hematologically healthy persons aged ≥60 years. Results Data of 30,611 persons aged ≥60 years were evaluated by age groups. Results for leukocytes, basophils, eosinophils, neutrophils and lymphocytes remained within the reference ranges recommended by the German Society of Hematology and Oncology (DGHO) and the German Association of Specialists in Internal Medicine (BDI); the lower reference limit for normal platelet values in males was below the DGHO reference value with 136,000/μL (confidence interval [CI] 129,000;142,000); similarly, our results for normal monocyte values were above the DGHO reference values with 6.0% (5.7;6.2) to 14.3% (13.9;14.8) in males and 5.4% (5.2;5.6) to 12.9% (12.6;13.4) in females; CRP, GGT and LDH values were above the BDI reference values, comparable with the previous data of a senior patient cohort analysis. Conclusions Adaptation of reference values for selected laboratory parameters in older German patients should be well considered.

Reference values of blood cell counts in the first days of life

10.2741/295 ◽  
2009 ◽  
Vol E3 (1) ◽  
pp. 871
Author(s):  
Giovanni Melioli
Keyword(s):  
Blood Cell ◽  
Reference Values ◽  
Cell Counts ◽  
Blood Cell Counts

An Alternative Elastase-mediated Degradation of Fibrinogen and Fibrin Observed in a Patient with Herpes Simplex Encephalitis and Pneumonia

1996 ◽  
Vol 76 (02) ◽  
pp. 184-186 ◽  
Author(s):  
Kenji lijima ◽  
Fumiyo Murakami ◽  
Yasushi Horie ◽  
Katsumi Nakamura ◽  
Shiro Ikawa ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Blood Cell ◽  
White Blood Cell ◽  
Herpes Simplex Encephalitis ◽  
Pmn Elastase ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Sds Page ◽  
White Blood Cell Counts ◽  
Pmn Élastase

SummaryA 74-year-old female developed pneumonia following herpes simplex encephalitis. Her white blood cell counts reached 28,400/μl, about 90% of which consisted of granulocytes. The polymorphonuclear (PMN) elastase/α1-arantitrypsin complex levels increased and reached the maximum of 5,019 ng/ml, indicating the release of a large amount of elastase derived from the granulocytes. The mechanism of PMN elastase release was most likely to be granulocyte destruction associated with phagocytosis. The cleavage of fibrinogen and fibrin by PMN elastase, independent of plasmin, was indicated by the presence of the fragments in immunoprecipitated plasma from the patient corresponding to elastase-induced FDP D and DD fragments and the absence of fragments corresponding to plasmin-induced FDP D and DD fragments on SDS-PAGE. These findings suggested that the large amount of PMN elastase released from the excessive numbers of granulocytes in this patient with herpes simplex encephalitis and pneumonia, induced the cleavage of fibrinogen and fibrin without the participation of plasmin.

Mediational g-formula for time-varying treatment and repeated-measured multiple mediators: Application to atorvastatin’s effect on cardiovascular disease via cholesterol lowering and anti-inflammatory actions in elderly type 2 diabetics

2021 ◽  
pp. 096228022110259
Author(s):  
Shintaro Yamamuro ◽  
Tomohiro Shinozaki ◽  
Satoshi Iimuro ◽  
Yutaka Matsuyama
Keyword(s):  
Cardiovascular Disease ◽  
Blood Cell ◽  
Indirect Effects ◽  
Time Varying ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Anti Inflammatory ◽  
White Blood Cell Counts ◽  
Inflammatory Action

Modern causal mediation theory has formalized several types of indirect and direct effects of treatment on outcomes regarding specific mediator variables. We reviewed and unified distinct approaches to estimate the “interventional” direct and indirect effects for multiple mediators and time-varying variables. This study was motivated by a clinical trial of elderly type-2 diabetic patients in which atorvastatin was widely prescribed to control patients’ cholesterol levels to reduce diabetic complications, including cardiovascular disease. Among atorvastatin’s preventive side-effects (pleiotropic effects), we focus on its anti-inflammatory action as measured by white blood cell counts. Hence, we estimate atorvastatin’s interventional indirect effects through cholesterol lowering and through anti-inflammatory action, and interventional direct effect bypassing these two actions. In our analysis, total effect (six-year cardiovascular disease risk difference) estimated by standard plug-in g-formula of −3.65% (95% confidence interval: −10.29%, 4.38%) is decomposed into indirect effect via low-density lipoprotein cholesterol (−0.90% [−1.91%, −0.07%]), via white blood cell counts (−0.03% [−0.22%, 0.11%]), and direct effect (−2.84% [−9.71%, 5.41%]) by the proposed parametric mediational g-formula. The SAS program and its evaluation via simulated datasets are provided in the Supplemental materials.

scholarly journals Changes of Hematocrit, Hemoglobin, Serum Protein Levels and Red Blood Cell Counts Before and After Stroke

1976 ◽  
Vol 13 (4) ◽  
pp. 207-214
Author(s):  
Hiroshi Yamanouchi ◽  
Hideo Tohgi ◽  
Masakuni Kameyama ◽  
Mototaka Murakami ◽  
Tamotsu Matsuda
Keyword(s):  
Blood Cell ◽  
Serum Protein ◽  
Red Blood Cell ◽  
Protein Levels ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Before And After
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