Effective approach to a synthesis of fluorine-containing 4-acylamino-4,5,6,7-tetrahydrobenzisoxazoles
2020 ◽
Vol 63
(6)
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pp. 716-720
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On the example of synthesis of 4-acetylamino-3-fluoroalkyl(aryl)-4,5,6,7-tetrahydro-1,2-benzisoxazoles, the effective approach to a synthesis of novel 4-acylamino-4,5,6,7-tetrahydro-1,2-benzisoxazoles is proposed. 3-Fluoroalkyl(aryl)- 6,7-dihydro-1,2-benzisoxazol-4-ones were reduced by a sodium borohydride in isopropanol to obtain 3-fluoroalkyl(aryl)- 4,5,6,7-tetrahydro-1,2-benzisoxazol-4-ols that in the conditions of the Ritter reaction (acetonitrile, acetic acid, sulfuric acid) gave target 4-acylamino derivatives with 80–94 % yields.
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2011 ◽
Vol 21
(34)
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pp. 12842
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2006 ◽
Vol 3
(12)
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pp. 940-942
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2009 ◽
Vol 82
(6)
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pp. 1025-1028
1975 ◽
Vol 48
(11)
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pp. 3107-3110
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2008 ◽
Vol 140
(1)
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pp. 53-56
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