Opportunities to restore sexual function in reproductive-aged women after treatment for endometrial cancer and borderline ovarian tumors

Background: Borderline ovarian tumors are non-invasive tumors that display greater epithelial proliferation and cytological atypia than benign tumors, but less than carcinomas. They may be treated conservatively in young women, however there is a concern for recurrence and progression to frank malignancy. We aimed to study the clinicopathological features of borderline ovarian tumors and their risk of recurrence.Methods: We reviewed the electronic and paper charts of all borderline ovarian tumors operated between January 1, 2001 and December 31, 2019 at a tertiary level teaching hospital in India. Descriptive statistics such as proportions and means were used. A survival analysis was done for recurrence and death.Results: A total of 93 borderline ovarian tumor patients were identified. The most common histology in our study was mucinous 60 (63%) followed by serous 28 (29%). Ninety two (99%) of them were stage I at diagnosis. Microinvasion was present in 27 (26%) of the cases. Out of the 30 fertility sparing operations performed (unilateral salpingo-oophorectomy/cytectomy), 4 (13%) had recurrences and progressed to malignancy. The overall malignancy rate was 4%. There was one mortality secondary to septic shock.Conclusions: Borderline ovarian tumors account for 10-20% of ovarian epithelial tumors and have extremely good prognosis affecting majorly the reproductive aged women. The low recurrence rate and good five year survival rate, at all the stages of the disease enables to incorporate fertility sparing surgeries as part of the staging.

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Management of Borderline Ovarian Tumors (BOT): results of a retrospective, single center study in Switzerland

10.1055/s-0040-1718202 ◽

2020 ◽

Author(s):

B Kipp ◽

A Vidal ◽

C Braun ◽

C Christmann

Keyword(s):

Ovarian Tumors ◽

Single Center ◽

Borderline Ovarian Tumors ◽

Single Center Study ◽

Center Study

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Assessment of lymphocyte iNKT+/CD3+/CD161+ in blood and tumor tissue in cases of benign ovarian tumors, borderline ovarian tumors and advanced-stage ovarian carcinomas

10.26226/morressier.597eedbad462b80296ca1465 ◽

2017 ◽

Author(s):

Winkler Izabela

Keyword(s):

Tumor Tissue ◽

Ovarian Tumors ◽

Advanced Stage ◽

Ovarian Carcinomas ◽

Borderline Ovarian Tumors ◽

Benign Ovarian Tumors

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Salpingo-oophorectomy versus cystectomy in patients with borderline ovarian tumors: a systemic review and meta-analysis on postoperative recurrence and fertility

World Journal of Surgical Oncology ◽

10.1186/s12957-021-02241-2 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Peng Wang ◽

Lei Fang

Keyword(s):

Surgical Procedures ◽

Postoperative Recurrence ◽

Pregnancy Rates ◽

Ovarian Tumors ◽

Systemic Review ◽

Cochrane Library ◽

Risk Of Recurrence ◽

Borderline Ovarian Tumors ◽

Surgical Methods ◽

Meta Analyses

Abstract Background To compare the postoperative recurrence and fertility in patients with borderline ovarian tumors (BOTs) who underwent different surgical procedures: salpingo-oophorectomy versus cystectomy. Methods Potentially relevant literature from inception to Nov. 06, 2020, were retrieved in databases including Cochrane Library, EMBASE (Ovid), and MEDLINE (Pubmed). We applied the keywords “fertility-sparing surgery,” or “conservative surgery,” or “cystectomy,” or “salpingo-oophorectomy,” or “oophorectomy,” or “adnexectomy,” or “borderline ovarian tumor” for literate searching. Systemic reviews and meta-analyses were performed on the postoperative recurrence rates and pregnancy rates between patients receiving the two different surgical methods. Begger’s methods, Egger’s methods, and funnel plot were used to evaluate the publication bias. Result Among the sixteen eligible studies, the risk of recurrence was evaluated in all studies, and eight studies assessed the postoperative pregnancy rates in the BOT patients. A total of 1839 cases with borderline ovarian tumors were included, in which 697 patients (37.9%) received unilateral salpingo-oophorectomy and 1142 patients (62.1%) underwent unilateral/bilateral cystectomy. Meta-analyses showed that BOT patients with unilateral/bilateral cystectomy had significantly higher recurrence risk (OR=2.02, 95% CI: 1.59-2.57) compared with those receiving unilateral salpingo-oophorectomy. Pooled analysis of four studies further confirmed the higher risk of recurrence in patients with cystectomy (HR=2.00, 95% CI: 1.11-3.58). In addition, no significant difference in postoperative pregnancy rate was found between patients with the two different surgical procedures (OR=0.92, 95% CI: 0.60-1.42). Conclusion Compared with the unilateral/bilateral cystectomy, the unilateral salpingo-oophorectomy significantly reduces the risk of postoperative recurrence in patients with BOT, and it does not reduce the pregnancy of patients after surgery. Trial registration PROSPERO CRD42021238177

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Ovulation induction treatment and risk of borderline ovarian tumors

Gynecological Endocrinology ◽

10.1080/09513590701350341 ◽

2007 ◽

Vol 23 (7) ◽

pp. 373-376 ◽

Cited By ~ 23

Author(s):

Maite Cusidó ◽

Rafael Fábregas ◽

Pere Barris S ◽

Cecilia Escayola ◽

Pere Nolsac Barri

Keyword(s):

Ovulation Induction ◽

Ovarian Tumors ◽

Induction Treatment ◽

Borderline Ovarian Tumors

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Influence of lymph node involvement or lymphadenectomy on prognosis of patients with borderline ovarian tumors: A systematic review and meta-analysis

Gynecologic Oncology ◽

10.1016/j.ygyno.2021.05.033 ◽

2021 ◽

Author(s):

Yu Fan ◽

Yu-fei Zhang ◽

Meng-yao Wang ◽

Yi Mu ◽

Si-ping Mo ◽

...

Keyword(s):

Systematic Review ◽

Lymph Node ◽

Meta Analysis ◽

Lymph Node Involvement ◽

Ovarian Tumors ◽

Borderline Ovarian Tumors ◽

Node Involvement

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Minimally invasive treatment options to borderline ovarian tumors

10.1055/s-0039-1685392 ◽

2016 ◽

Author(s):

Punita Bhardwaj ◽

T. K. Das ◽

S. Batra ◽

Keyword(s):

Early Stage ◽

Treatment Options ◽

Malignant Potential ◽

Ovarian Tumors ◽

Conservative Approach ◽

Uncertain Malignant Potential ◽

Invasive Treatment ◽

Younger Women ◽

Borderline Ovarian Tumors

Borderline Ovarian tumors are tumors of uncertain malignant potential. They have favour able prognosis. They occur in younger women and present at an early stage. They are difficult to diagnose preoperatively as macroscopic picture is a combination of benign and invasive ovarian tumors. Over the years surgical treatment has changed from radical to conservative approach without overlooking oncologic safety. Follows up is essential. Prolonged follow up (>10 yrs) is required because of later recurrences. Special attention is to be paid to the conserved ovary in follow up.

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