EFFECT OF DRUGS;

ABSTRACT... Objective: The aim of this study was to determine head-dipping exploratory test parameter as a measure of strongmodulating effect on brain and behavior. Design: It was an observational animal study. Setting: University of Karachi. Period: Jan 2004 toJuly 2006. Material & methods: In this present study, drugs used reserpine, nux- vomica; anacardium and chlorpromazine were widerange of pharmacological actions. We evaluate the effectiveness of these drugs as agents with modulating effect on brain and behavioraccessed by head dipping parameter. In this study, 25 mice were included belonging to both sexes. The study animals were divided intofive groups of five animals each. Four groups were given drugs and one group was kept as control. Mice (20-35g) of either sex were usedin this study. One group was kept as control for drugs. Mice were kept under room temperature. Tap-water was allowed ad-Libitum.30minutes after giving drugs, animals were observed for 10 minutes with two minutes of interval. Tablet crushed in 10ml of water, 1cc wasgiven. Screening method used was head dipping. Results: Strychnos Nux-Vomica when used in a dose of 0.07mg has strong action oncholinergic system, CNS activity and frequent head dipping (39.8±28.8) was observed. Rauwolfia serpentine is an active alkaloidparticularly present in reserpine (62.2±43.4) no significant head dipping effect was observed. Anacardium (37.2±28.6) &Chlorpromazine (39.4±32.4), show decrease effects. Keeping in view, the medicinal importance of these herbs, our present study wasdesigned to screen these drugs for CNS activity on albino mice.

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PSYCHOPHARMACOLOGICAL ACTIVITY;

The Professional Medical Journal ◽

10.29309/tpmj/2012.19.02.2029 ◽

2012 ◽

Vol 19 (02) ◽

pp. 264-269

Author(s):

SAIMA AHMED ◽

Muhammad ASADULLAH

Keyword(s):

Tap Water ◽

Screening Method ◽

Wide Range ◽

Psychotropic Agents ◽

Strong Action ◽

The Central Nervous System ◽

Cns Activity ◽

Brain And Behavior ◽

And Behavior ◽

Psychopharmacological Activity

Objective: The purpose of this study was to screen some herbal medicine as psychotropic drugs those has strong modulatingeffect on brain and behavior. Material & methods: Herbal drug Reserpine, Nux- Vomica, Anacardium and Chlorpromazine with a wide range ofpharmacological actions. In our present study, we evaluate the effectiveness of these drugs as Psychotropic agents and accessed bybiochemical-parameters. Rats (weighing 180-250g) and Mice (22-32g) either sex were used in this study. One group was kept as control fordrugs. Mice were kept under room temperature. Tap-water was allowed ad-Libitum. Animals were observed during and after 21 days. A tabletcrushed in 10ml of water, 1cc was given. Screening method used was swimming induced-despair. Results: Among these, Strychnos Nux-Vomica has strong action on cholinergic system, CNS activity and observed as an antispasmodic. Rauwolfia serpentine is an active alkaloidparticularly present in reserpine are used to treat essential hypertension and in certain neuropsychiatry disorders. It has sedative andtranquilizing effects, as it depletes catecholamine from the central nervous system. Keeping in view, the medicinal importance of these herbs,our present study was designed to screen these herbs as for CNS activity on Albino mice and rats.

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