scholarly journals Hepatitis E associated fulminant hepatic failure and its outcome in pregnancy.

2020 ◽  
Vol 27 (10) ◽  
pp. 2165-2169
Author(s):  
Zahida Parveen Brohi ◽  
Uzma Parveen ◽  
Aneela Sadaf
Keyword(s):  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
First Trimester ◽  
Hepatitis E ◽  
University Hospital ◽  
Fetal Mortality ◽  
Clinical Issue ◽  
Viral Marker ◽  
Study Results ◽  
In Pregnancy

Objectives: To determine the clinical features and outcome of hepatitis E associated fulminant hepatic failure in pregnancy. Study Design: Observational Retrospective study. Setting: Department of Obstetrics & Gynecology at Isra University Hospital Hyderabad. Period: Three years from 1st January 2015 to 31st December 2017. Material & Methods: Total 3596 obstetric patients were admitted whom 168 pregnant women who were positive for hepatitis E viral marker have been included in the study. Results: Their age was between 18 to 47 years with mean age 26.04±6.40 years; majority of patients had not received antenatal care 123 (73.2%). Out of 168, 27 (16%) presented in the first trimester, 45 (26.7%) presented in the second trimester, while 96 (57.1%) patients developed fulminant hepatic failure in their 3rd trimester of pregnancy. Out of 168, 111(66%) patients delivered and 57 (33.9%) were undelivered. Fetal and perinatal outcome of delivered patients showed miscarriage 45 (40.5%), stillborn 25(14.8%), preterm delivery 17(15.3%), neonatal death 7 (6.3%) and 17 (15.3%) new born remained alive. Overall maternal mortality was 51 (30.3%). Conclusion: Hepatitis – E related fulminant hepatic failure in pregnancy is a troublesome clinical issue and connected with exceptionally high maternal and fetal mortality. Appropriate diagnosis, early timely intervention can considerably diminish the morbidity and mortality associated with (HEV) Fulminant hepatic failure. 

scholarly journals Fulminant hepatic failure during pregnancy.

2021 ◽  
Vol 28 (10) ◽  
pp. 1501-1507
Author(s):  
Zahra Nazish ◽  
Muhammad Inayatullah ◽  
Fatima Tu Zahra
Keyword(s):  
Maternal Mortality ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Urban Areas ◽  
Case Series ◽  
Hepatitis E ◽  
Fetal Mortality ◽  
Common Cause ◽  
Study Results ◽  
Common Clinical Presentation

Objective: To observe clinical characteristics, etiology and maternal outcome in fulminant hepatic failure during pregnancy. Study Design: Descriptive Case Series. Setting: Department of Medicine, Nishtar Hospital Multan. Period: January 2013 to December 2017. Material & Methods: Twenty nine consecutive patients with fulminant hepatic failure during pregnancy were included in the study. Results: Mean age of patients was 27.06±6.92 years. 65.51% patients were from urban areas. Mean duration of gestation was 24.80±6.03 weeks. Jaundice and altered consciousness were observed in 100% cases, pallor in 79.31%, hepatomegaly in 20.68%, flapping tremors in 10.34%, ascites in 10.34% and splenomegaly in 6.89% cases. Complications observed were cerebral edema in 44.82%, renal failure in 24.13%, bleeding in 20.68% and hypoglycemia in 3.44%. Most common cause was acute hepatitis E (75.86%) followed by hepatitis B (13.79%) and hepatitis A (3.44%). No cause was found in 6.89% cases. Overall maternal mortality was 37.93% and fetal mortality was 72.41%. In 17.24% cases pregnancy was terminated therapeutically, 44.82% cases had spontaneous expulsion and in 37.93 % cases pregnancy continued. Maternal mortality was highest (45.45%) in patients who remained pregnant as compared to 20% when pregnancy was terminated therapeutically. Conclusion: Jaundice and altered conscious level is the most common clinical presentation. Hepatitis E is the most common cause of FHF in pregnancy. Maternal mortality in FHF during pregnancy is very high.

scholarly journals Pregnancy Outcome in Viral Hepatitis

2013 ◽  
Vol 5 (2) ◽  
pp. 60-63
Author(s):  
Sulbha Joshi ◽  
Varsha Kose
Keyword(s):  
Viral Hepatitis ◽  
Pregnancy Outcome ◽  
Hepatitis E ◽  
Fetal Outcome ◽  
Research Centre ◽  
Premature Delivery ◽  
Fetal Mortality ◽  
Obstetrics And Gynecology ◽  
Major Public Health Problem ◽  
In Pregnancy

ABSTRACT Introduction Hepatitis in pregnancy is an important medical disorder seen more often in developing countries than in developed ones. Viral hepatitis is a major public health problem in India. Hepatitis in pregnancy is commonly associated with abortion, premature delivery, postpartum hemorrhage, coagulation defect, obstetric shock, coma, death and increased perinatal mortality and morbidity. This study was carried out to know the effect of viral hepatitis on pregnancy and to study its maternal and fetal outcome. Materials and methods This prospective clinical study was conducted in the Department of Obstetrics and Gynecology NKP Salve Institute of Medical Sciences and Research Centre and Lata Mangeshkar Hospital, Nagpur, from January 2010 to December 2012. All the antenatal cases attended Obstetrics and Gynecology Department were investigated for HBsAg and looked for any symptoms and signs suggesting hepatitis like fever, jaundice, nausea, vomiting. If present, they were admitted and further investigated to detect viral hepatitis. Patients were counseled for follow-up and strict hospital delivery. Patients with viral hepatitis were analyzed for the effect on pregnancy, maternal and fetal outcome. Results There were total 30 cases of viral hepatitis 24 (80%) cases were HBsAg positive, but all were asymptomatic 6 (20%) cases were hepatitis E positive. No HAV, HCV, HDV and hepatitis G infected cases were detected in our study. Maternal and fetal morbidity was significantly higher in hepatitis E infected women. Fetal mortality was observed in one case. Conclusion Pregnancy with viral hepatitis requires early diagnosis, hospitalization and treatment. In the present study hepatitis E was found to be the chief etiological agent associated with increased maternal morbidity, and high fetal morbidity and mortality. How to cite this article Kose V, Joshi S. Pregnancy Outcome in Viral Hepatitis. J South Asian Feder Obst Gynae 2013;5(2): 60-63.

Fulminant hepatic failure due to hepatitis E virus

1994 ◽  
Vol 21 (6) ◽  
pp. 1156-1157
Author(s):  
Rakesh Aggarwal ◽  
Hansa Shahi ◽  
Sita Naik ◽  
Subhash R. Naik ◽  
Soniya Nityanand ◽  
...  
Keyword(s):  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Hepatitis E Virus ◽  
Hepatitis E
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