scholarly journals Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A case with adverse reaction to three drugs alternately administered

2021 ◽  
Vol 4 (1) ◽  
pp. 001-005
Author(s):  
Manieri Sergio ◽  
Mirauda Maria P ◽  
De Gregorio Fabiola ◽  
Colangelo Carmela ◽  
Tagliente Maria ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Drug Reaction ◽  
Case Report ◽  
Mortality Rate ◽  
Hypersensitivity Reaction ◽  
Genetic Predisposition ◽  
Intravenous Immunoglobulins ◽  
Dress Syndrome ◽  
Pediatric Case ◽  
Systemic Symptoms

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe multiorgan hypersensitivity reaction mostly caused by several eliciting drugs in patients with a genetic predisposition. Incidence of DRESS in children is very variable, frome 1:1000 to 1:10.000, and the mortality rate seems to be lower than 10%. Anti-convulsants are the main drugs involved both in adults and in children. The treatment of choice is the prompt withdrawn of the offending drug and using intravenous immunoglobulins and corticosteroids used in synergy. In recent years, emerging studies have outlined the disease more clearly. We present a pediatric case in which the patient developed DRESS syndrome as a result of exposure to lamotrigine before and carbamazepine after and a relapse after exposure to omeprazole. Starting from this case report we provide an overview on DRESS Syndrome.

scholarly journals Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome)

2016 ◽  
Vol 62 (3) ◽  
pp. 227-230 ◽  
Author(s):  
Soraia Aparecida da Silva ◽  
Mariana Maciel Pereira de Figueiredo ◽  
Lauro Carneiro Neto ◽  
Débora Borowiak Reiss ◽  
Mariana Amaranto de Souza Damásio
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Literature Review ◽  
Hypersensitivity Reaction ◽  
Laboratory Tests ◽  
Immune Status ◽  
Target Organ ◽  
Dress Syndrome ◽  
Risk Of Mortality ◽  
Systemic Symptoms

SUMMARY Objective: To review the hypersensitivity reaction to drugs known as drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), based on a case report. We also intend to discuss the difficulty and importance of disease recognition, since none of the changes is pathognomonic of this disease and failure to identify it may have disastrous consequences for the patient. Method: To describe this case report, in addition to the information collected for clinical assessment, a literature review was performed in the PubMed and Bireme databases in order to retrieve the latest information published in literature on DRESS syndrome. Results: The case of a 20-year old patient is reported. After anamnesis, physical examination and laboratory tests a diagnosis of DRESS syndrome was performed, characterized by rash, hematologic alterations, lymphadenopathy and lesions in target organ. This is a rare syndrome, whose frequency varies according to the drug used and the immune status of the patient, being more often associated with the use of anticonvulsants. Conclusion: The approach and discussion of the topic are of paramount importance, in view of the potential lethality of this treatable syndrome. Recognizing the occurrence of DRESS syndrome and starting treatment as soon as possible is crucial to reduce the risk of mortality and improve prognosis.

scholarly journals Sulfasalazine-induced DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms)

2008 ◽  
Vol 126 (4) ◽  
pp. 225-226 ◽  
Author(s):  
Renata Telles Rudge de Aquino ◽  
Carmen Silvia Vieitas Vergueiro ◽  
Maria Elisa Ruffolo Magliari ◽  
Thais Helena Proença de Freitas
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Mortality Rate ◽  
High Morbidity ◽  
Seronegative Arthritis ◽  
Dress Syndrome ◽  
Brazilian Woman ◽  
Causative Drug ◽  
Drug Rash ◽  
Systemic Symptoms

CONTEXT: DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a type of drug reaction commonly mistaken for a viral infection. It must be recognized promptly due to its high morbidity and 10% mortality rate. Few cases of DRESS syndrome induced by sulfasalazine have been reported in the literature. CASE REPORT: The case of a 47-year-old white Brazilian woman who developed DRESS syndrome eight weeks after starting a course of sulfasalazine for treatment of seronegative arthritis is reported. She presented a skin rash, fever, hepatitis, lymphadenopathy, eosinophilia and atypical lymphocytes. The causative drug was discontinued immediately, but she only improved after treatment with prednisone.

scholarly journals Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated with cefotaxime and clindamycin use in a 6 year-old boy: a case report

2017 ◽  
Vol 28 ◽  
Author(s):  
Burcu Karakayali ◽  
Ahmet Sami Yazar ◽  
Deniz Çakir ◽  
Aysen Cetemen ◽  
Mandana Kariminikoo ◽  
...  
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Dress Syndrome ◽  
Systemic Symptoms

scholarly journals Vancomycin-Induced DRESS Syndrome: An Important Concern in Orthopedic Surgery

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Emma Littlehales ◽  
Odhrán Murray ◽  
Robert Dunsmuir
Keyword(s):  
Drug Reaction ◽  
Mortality Rate ◽  
Antibiotic Treatment ◽  
Orthopedic Surgery ◽  
Scoring System ◽  
Steroid Treatment ◽  
Dress Syndrome ◽  
Important Concern ◽  
Criteria For Diagnosis ◽  
Systemic Symptoms

DRESS (drug reaction with eosinophilia and systemic symptoms) is a potentially serious complication when prolonged courses of antibiotics are given to patients, with an average onset of 2–6 weeks after commencement. There is a high mortality rate (1–10%). We report the case of a 62-year-old male who developed DRESS after seven weeks of antibiotic treatment with vancomycin for a deep spinal metalwork infection. We describe the typical rash and biochemical results, including eosinophilia, as well as the systemic signs seen in this case. The criteria for diagnosis of DRESS, including the RegiSCAR scoring system and commonly affected systems (renal, cardiac, and hepatic), are detailed, and we also discuss evidence for steroid treatment and considerations important in the use of this.

scholarly journals Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Secondary to Furosemide: Case Report and Review of Literature

2018 ◽  
Vol 19 ◽  
pp. 163-170 ◽  
Author(s):  
Jared James ◽  
Yasser M. Sammour ◽  
Andrew R. Virata ◽  
Terri A. Nordin ◽  
Igor Dumic
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Review Of Literature ◽  
Dress Syndrome ◽  
Systemic Symptoms

scholarly journals Pseudomembranous colitis in a patient with lamotrigine-induced drug rash with eosinophilia and systemic symptoms syndrome

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Manuel Soria Orozco ◽  
Eduardo Martín Nares ◽  
Alvaro López Iñiguez ◽  
Sandra Gónzalez Saldaña ◽  
Lorena Valerdi Contreras ◽  
...  
Keyword(s):  
Drug Reaction ◽  
Gastrointestinal Tract ◽  
Liver Function ◽  
Hypersensitivity Reaction ◽  
Pseudomembranous Colitis ◽  
Hispanic Woman ◽  
Gastrointestinal Involvement ◽  
Dress Syndrome ◽  
Drug Rash ◽  
Systemic Symptoms

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a hypersensitivity reaction with rash, fever and multiorgan dysfunction potentially lethal in up to 10% of cases. It often affects liver function, but it can also affect kidney, lungs, and heart. Severe gastrointestinal involvement is rare. We present a case of a 31-year-old hispanic woman with pseudomembranous colitis associated with lamotrigine-induced DRESS syndrome. To the best of our knowledge, this is the fourth reported case of severe involvement of the gastrointestinal tract and the first to report pseudomembranous colitis in the setting of DRESS syndrome.

DRESS syndrome: an important differential for eosinophilia with systemic organ dysfunction

2020 ◽  
Vol 13 (5) ◽  
pp. e234251 ◽  
Author(s):  
Whoasif Mukit ◽  
Richard Cooper ◽  
Harmesh Moudgil ◽  
Nawaid Ahmad
Keyword(s):  
Adverse Drug Reaction ◽  
Adverse Reaction ◽  
Drug Reaction ◽  
Clinical Response ◽  
Organ Dysfunction ◽  
Patient Harm ◽  
Dress Syndrome ◽  
Cutaneous Adverse Reaction ◽  
Drug Rash ◽  
Systemic Symptoms

Drug rash occurring with eosinophilia and systemic symptoms syndrome is a potentially fatal adverse drug reaction that requires immediate action in order to minimise patient harm. Initially implicated with the use of anticonvulsants, it has also been shown to be caused by many other medications but less frequently with vancomycin. Patients typically present with fever, lymphadenopathy, eosinophilia and systemic organ dysfunction. Diagnosis is aided using probability calculators such as RegiSCAR (Registry of Severe Cutaneous Adverse Reaction), as well as clinical response on removing the responsible medication. Here, we present a case without any systemic organ dysfunction that improved with withdrawal of the offending drug vancomycin.

scholarly journals Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review

Children ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 1063
Author(s):  
Chien-Heng Lin ◽  
Sheng-Shing Lin ◽  
Syuan-Yu Hong ◽  
Chieh-Ho Chen ◽  
I-Ching Chou
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Skin Rash ◽  
Stable Condition ◽  
Anticonvulsant Drug ◽  
Dress Syndrome ◽  
Life Threatening ◽  
History Of ◽  
History Of Epilepsy ◽  
Systemic Symptoms

Lamotrigine is an important anticonvulsant drug. Its use, however, has been limited by the risk of potentially life-threatening dermatological reactions, such as a drug reaction with eosinophilia and systemic symptoms (DRESS). Here, we report the case of a 7-year-6-month-old girl with a history of epilepsy who developed a skin rash with dyspnoea after 2 weeks of lamotrigine treatment, with DRESS ultimately being diagnosed. After discontinuation of the offending drug and the initiation of systemic glucocorticosteroids, the DRESS symptoms were relieved and the patient was discharged in a stable condition. Anticonvulsant drugs such as lamotrigine are among the factors that induce DRESS in children. When a patient displays skin rash and systemic organ involvement following the initiation of an anticonvulsant drug, DRESS should not be overlooked as a diagnosis, and immunosuppressant drugs should be considered as an option for treating DRESS patients.

scholarly journals Drug reaction with eosinophilia and systemic symptom induced by carbamazepine: a case report

2019 ◽  
Vol 8 (5) ◽  
pp. 1115
Author(s):  
Rahul R. Damor ◽  
Amita R. Kubavat ◽  
Kiran G. Piparva
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Antiepileptic Drugs ◽  
Drug Exposure ◽  
Latency Period ◽  
Systemic Symptom ◽  
Dress Syndrome ◽  
Period 2 ◽  
Life Threatening ◽  
Systemic Symptoms

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, potentially life-threatening acute adverse drug reaction (ADR), typically characterized by a long latency period (2-6 weeks to 3 months) from drug exposure. DRESS syndrome is defined by the presence of fever, cutaneous eruption, lymphadenopathy, systemic or asymptomatic internal organ involvement (e.g. Hepatitis, carditis, interstitial nephritis, interstitial pneumonitis, etc.) and haematological abnormalities, mainly leucocytosis, eosinophilia and sometimes atypical lymphocytosis. There are around 50 culprit drugs which cause DRESS syndrome e.g. carbamazepine, phenytoin, allopurinol, sulfa derivatives, antidepressants, antiepileptics, non-steroidal anti-inflammatory drugs and antimicrobials. The incidence of DRESS syndrome has been estimated to be between 1 in 1,000 and 1 in 10,000 drug exposures. There are many reported cases of DRESS syndrome due to carbamazepine, phenytoin, vancomycin, levitiracitam, ceftriaxone etc. Author presented a case of DRESS syndrome by carbamazepin. RegiSCAR and Japanese consensus group have developed specific criteria for making the diagnosis of DRESS syndrome. The patient described here met the majority of criteria according to RegiSCAR scoring guidelines for a diagnosis of DRESS syndrome induced by carbamazepine. As per RegiSCAR diagnostic criteria author had concluded that this was a “Definite” case of DRESS (Drug Reaction with Eosinophilia and Systemic Symptom) syndrome induced by carbamazepine. Carbamazepine is most common broad-spectrum antiepileptic drugs so, this case report will raises awareness among physician to suspect DRESS syndrome in patients who present unusual complaints and skin findings after starting antiepileptic drugs.

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