scholarly journals Risk factors of clinically relevant pancreatic fistula after distal pancreatectomy for pancreatic cancer

Suizo ◽  
2017 ◽  
Vol 32 (2) ◽  
pp. 155-161
Author(s):  
Sokichi MATSUMOTO ◽  
Yusuke WATANABE ◽  
Kanako KURATA ◽  
Kazuyoshi NISHIHARA ◽  
Toru NAKANO
2021 ◽  
Vol 28 (2) ◽  
pp. 33-45
Author(s):  
E. S. Drozdov ◽  
E. B. Topolnitskiy ◽  
S. S. Klokov ◽  
T. V. Dibina

Background. Despite declining mortality, postoperative pancreatic fistula (PPF) remains a common complication of distal pancreatic resection surgery challenging to clinical prediction.Objectives. Prognostic analysis of the postoperative pancreatic fistula risk factors in patients with previous distal pancreatectomy.Methods. A retrospective controlled assay enrolled 107 patients, including 63 (58.9%) male and 44 (41.1%) female patients. All patients underwent distal pancreatectomy followed by a morphological examination of resected material. All patients had a general and biochemical blood panel profiling. Pancreatic tissue density at a putative resection zone was assessed with computed tomography. The patients were allocated to two cohorts: (1) not developing PPF (77 patients) and (2) having postoperative PPF complications (30 patients.Results. No statistically significant differences by age, gender, ASA and BMI scores were observed in study cohorts. Multivariate analysis revealed a statistically significant correlation of the PPF rate with the following factors: main pancreatic duct diameter <3 mm (odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01–1.05, p = 0.01), pancreatic density at putative resection zone <30 HU in CT (OR 3.18, 95% CI 1.38–7.74, p < 0.01) and differential albumin of postoperative day 1 vs. pre-surgery >14 g/L (OR 3.13, 95% CI 1.19–8.24, p < 0.01).Conclusion. A main pancreatic duct diameter <3 mm, pancreatic density at putative resection zone <30 HU in CT and differential albumin of postoperative day 1 vs. pre-surgery >14 g/L are independent risk factors of postoperative fistulae.


2020 ◽  
Vol 75 ◽  
pp. S24-S25
Author(s):  
Gao Qing Wang ◽  
Dipesh Kumar Yadav

2010 ◽  
Vol 80 (9) ◽  
pp. 619-623 ◽  
Author(s):  
Chiow Adrian Kah Heng ◽  
Ibrahim Salleh ◽  
Tan Siong San ◽  
Feng Ying ◽  
Tan Su-Ming

2011 ◽  
Vol 58 (109) ◽  
pp. 1372-1376 ◽  
Author(s):  
Koji Soga ◽  
Toshiya Ochiai ◽  
Teruhisa Sonoyama ◽  
Koji Inoue ◽  
Hisashi Ikoma ◽  
...  

Surgery Today ◽  
2017 ◽  
Vol 48 (1) ◽  
pp. 95-100 ◽  
Author(s):  
Hiromichi Kawaida ◽  
Hiroshi Kono ◽  
Mitsuaki Watanabe ◽  
Naohiro Hosomura ◽  
Hidetake Amemiya ◽  
...  

Pancreatology ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. S127
Author(s):  
Ryutaro Mori ◽  
Ryusei Matsuyama ◽  
Yohei Ota ◽  
Seigo Hiratani ◽  
Koki Goto ◽  
...  

2018 ◽  
Vol 90 (2) ◽  
pp. 38-44
Author(s):  
Katarzyna Mech ◽  
Łukasz Wysocki ◽  
Tomasz Guzel ◽  
Marcin Makiewicz ◽  
Paweł Nyckowski ◽  
...  

Pancreatic fistula is one of the most severe complications after pancreatic surgeries. The risk of pancreatic fistula after distal pancreatectomy is up to 60%. Effective methods to prevent pancreatic fistula are still sought. A unified definition of pancreatic fistula, which was introduced in 2005 by the International Study Group of Pancreatic Surgery (ISGPS), has allowed for an easier diagnosis and determination of fistula severity, as well as for a reliable inter-center comparison of data. Furthermore, a number of publications point out the risk factors of pancreatic fistula, which may be classified into patient-related risk factors, such as MBI, gender, smoking tobacco or pancreatic structure; and surgery-related risk factors, such as blood loss, prolonged surgery and non-underpinning of the major pancreatic duct. The analysis of risk factors and the use of different methods for the prevention of pancreatic fistula, including novel surgical techniques, may reduce both, the formation and severity of fistula. This will, in turn, lead to reduced secondary complications and mortality, as well as a shorter hospital stay. We present a literature review on different strategies used to prevent pancreatic fistula. It seems, however, that multicenter, prospective, randomized studies in two large groups of patients after pancreatectomy are necessary to establish clear recommendations for the preventive management.


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