More than 30 earthquake loss assessment reports in Yunnan Province in 1993 – 2003 are collected. And the building loss in each intensity recalculated based on the all building area, destruction ratio, loss ratio and replacement cost which are listed in the reports. The relation curves of building loss versus affected population, affected area in each intensity are studied respectively using statistical regression method. After regression significance test, it is found that the relation of building loss and affected population is high; however, there is no obvious relevance of building loss versus affected area. So in this paper, the quantitative relation between the housing loss and earthquake-affected population in each intensity area is established in Yunnan Taking four earthquakes during 2004 ~ 2005 in Yunnan as examples; we estimated their earthquake building economic loss and compared them with the values taken from field investigation. The result shows this regression equations are useful and applicable for evaluating the building loss caused by earthquake.