Lymphoid environment in triple-negative invasive ductal breast carcinoma

10563 Background: The role of the insulin-like growth factor-1 receptor (IGF-1R) in the outcome of breast cancer is poorly understood. Therefore, we analyzed the prognostic value of IGF-1R expression in relation to clinically relevant tumor characteristics. Methods: Expression of IGF-1R, insulin receptor, estrogen receptor (ER), progesterone receptor (PR), HER2 receptor, epidermal growth factor receptor and phosphorylated Akt (pAkt) was determined on tissue microarrays comprising primary invasive ductal breast carcinoma samples of a consecutive series of 221 patients. Patients presented at the University Medical Center Groningen between 1996 and 2001. Patient records were reviewed for clinical and tumor parameters. Cytoplasmic and membranous IGF-1R staining were scored separately, as the relevance of IGF-1R cellular localization is yet unknown. Associations were tested by Chi-square, Log Rank test and Cox regression analysis. Results: Overall, IGF-1R expression was present in 79% of the tumors. Cytoplasmic staining was present in 69%, membranous in 52%, staining was combined cytoplasmic and membranous in 42% of the tumors. Cytoplasmic, but not membranous, IGF-1R staining was associated with expression of ER (p<0.001), PR (p=0.001), pAkt (p=0.04), and increased relapse free and overall survival (RFS, p=0.01; OS, p=0.006). No correlations with other parameters were found. In ER/PR positive, HER2 negative tumors, but not in HER2 positive tumors, cytoplasmic IGF-1R expression correlated with increased RFS (p=0.002) and OS (p=0.001). In contrast, in triple negative tumors cytoplasmic and membranous expression of IGF-1R were both significantly associated with shorter RFS (p=0.02, p=0.04, resp.). In multivariate analysis, cytoplasmic IGF-1R expression was an independent prognostic factor for OS (HR 0.3, 95% CI 0.1–0.9, p=0.035). Conclusions: Cytoplasmic IGF-1R expression in invasive ductal breast carcinoma is associated with hormone receptor expression, phosphorylated Akt and good prognosis. Surprisingly, triple negative tumors expressing IGF-1R have a worse prognosis than those without. These results suggest that IGF-1R targeted therapy may have additional value in the treatment of triple negative tumors. No significant financial relationships to disclose.

Download Full-text

Erratum: Bilateral Triple Negative Invasive Ductal Breast Carcinoma in a BRCA1 Mutation Carrier with Discrepant Pathologic Response to Neoadjuvant Chemotherapy

Journal of the Korean Society of Radiology ◽

10.3348/jksr.2020.81.3.753 ◽

2020 ◽

Vol 81 (3) ◽

pp. 753

Author(s):

Gi Won Shin ◽

Young Mi Park ◽

Tae Hyun Kim ◽

Anbok Lee ◽

Ha Young Park ◽

...

Keyword(s):

Breast Carcinoma ◽

Neoadjuvant Chemotherapy ◽

Mutation Carrier ◽

Triple Negative ◽

Brca1 Mutation ◽

Pathologic Response ◽

Brca1 Mutation Carrier ◽

Invasive Ductal Breast Carcinoma ◽

Ductal Breast Carcinoma ◽

Response To Neoadjuvant Chemotherapy

Download Full-text

Do NY-BR-1 and CD10 have a prognostic participation in invasive ductal breast carcinoma? An immunohistochemical correlational study

10.26226/morressier.578f37fcd462b8028d88f029 ◽

2016 ◽

Author(s):

Eiman Adel Hasby Saad

Keyword(s):

Breast Carcinoma ◽

Correlational Study ◽

Invasive Ductal Breast Carcinoma ◽

Ductal Breast Carcinoma

Download Full-text

Challenges in the correct assessment of a case of aggressive thyroid carcinoma with synchronous breast cancer, case report and review of the literature: essential role of radiopharmaceuticals

Current Radiopharmaceuticals ◽

10.2174/1874471013666200928105151 ◽

2020 ◽

Vol 13 ◽

Author(s):

Andra Piciu ◽

Alexandru Mester ◽

George Rusu ◽

Doina Piciu

Keyword(s):

Breast Cancer ◽

Papillary Thyroid Carcinoma ◽

Breast Carcinoma ◽

Thyroid Carcinoma ◽

Bone Metastases ◽

Essential Role ◽

Papillary Thyroid ◽

Invasive Ductal Breast Carcinoma ◽

Ductal Breast Carcinoma

Background: Thyroid carcinoma represents a complex pathology that can still be considered a medical challenge, despite having a better prognosis and life expectancy than most other neoplasms, also the scenario of multiple malignancies involving thyroid cancer is nowadays a common reality. Materials and methods: We reviewed the literature regarding the aggressive presentation of synchronous thyroid and breast cancer. In the current paper we are reporting the case of a 59 years-old woman, diagnosed with invasive ductal breast carcinoma and papillary thyroid carcinoma, presenting a natural history of both aggressive synchronous tumors. At the moment of hospitalization, the diagnostic was breast carcinoma with multiple secondary lesions, suggestive for lung and bone metastases, and nodular goiter. Results: Searching the literature PUBMED with the terms “thyroid carcinoma and synchronous breast carcinoma we found 86 studies; introducing the term “aggressive” the result included 4 studies, among them none being relevant for aggressive and synchronous. A similar search was done in SCOPUS finding 92 documents and after introducing the term aggressive, the number of papers was 8, none being for the synchronous aggressive metastatic thyroid and breast carcinoma. The majority of imaging diagnostic tools were used in this particular medical case, in order to ensure the best potential outcome. The final diagnostic was papillary thyroid carcinoma with lung and unusual multiple bone metastases and synchronous invasive ductal breast carcinoma with subcutaneous metastases. Conclusion: The case illustrates the challenges in correct assessment of oncologic patients, despite the advances in medical imaging and technologies and underlines the essential role of nuclear medicine procedures in the diagnostic and therapy protocols.

Download Full-text

Acute appendicitis as an unusual cause of invasive ductal breast carcinoma metastasis

Journal of Surgical Case Reports ◽

10.1093/jscr/rjaa535 ◽

2020 ◽

Vol 2020 (12) ◽

Author(s):

Vincent De Pauw ◽

Julie Navez ◽

Stephane Holbrechts ◽

Jean Lemaitre

Keyword(s):

Abdominal Pain ◽

Breast Carcinoma ◽

Acute Appendicitis ◽

Ductal Carcinoma ◽

Hormonal Treatment ◽

Locoregional Therapy ◽

Invasive Ductal Breast Carcinoma ◽

Ductal Breast Carcinoma ◽

History Of ◽

Anticancer Treatment

Abstract Acute appendicitis is one of the most common causes of abdominal pain at the emergency room. In rare cases, it can be caused by malignancy, even metastatic lesions from extra-abdominal neoplasia. Herein, we report a case of a 64-year-old female with a history of invasive ductal carcinoma of the breast treated by chemotherapy, surgery, radiotherapy and hormonotherapy, relapsing several years later as a bone and a pleura metastasis successfully cured by locoregional therapy and hormonal treatment. She presented with acute abdominal pain without signs of peritonitis. Abdominal computed tomodensitometry showed sign of appendicitis. Therefore, laparoscopic exploration and appendicectomy was performed. During surgery, multiple peritoneal nodules were found and harvested. Pathology showed metastatic nodules of invasive ductal breast carcinoma, including in the appendicular wall, concluding to peritoneal carcinomatosis. The postoperative course was uneventful, but the patient died 1 year later after refusing anticancer treatment.

Download Full-text