scholarly journals Divergent effects of insulin-like growth factor-1 receptor expression on prognosis of estrogen receptor positive versus triple negative invasive ductal breast carcinoma

2010 ◽  
Vol 129 (3) ◽  
pp. 725-736 ◽  
Author(s):  
Hermien Hartog ◽  
Hugo M. Horlings ◽  
Bert van der Vegt ◽  
Bas Kreike ◽  
Abderrahim Ajouaou ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Growth Factor ◽  
Breast Carcinoma ◽  
Triple Negative ◽  
Receptor Expression ◽  
Insulin Like Growth Factor ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma ◽  
Estrogen Receptor Positive

Insulin-like growth factor-1 receptor expression in invasive ductal breast carcinoma is related to tumor characteristics and prognosis

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 10563-10563
Author(s):  
H. Hartog ◽  
B. Van der Vegt ◽  
W. T. Van der Graaf ◽  
H. M. Boezen ◽  
G. H. De Bock ◽  
...  
Keyword(s):  
Growth Factor ◽  
Breast Carcinoma ◽  
Triple Negative ◽  
Receptor Expression ◽  
Insulin Like Growth Factor ◽  
Tumor Characteristics ◽  
Invasive Ductal Breast Carcinoma ◽  
Cytoplasmic Staining ◽  
Ductal Breast Carcinoma ◽  
Phosphorylated Akt

10563 Background: The role of the insulin-like growth factor-1 receptor (IGF-1R) in the outcome of breast cancer is poorly understood. Therefore, we analyzed the prognostic value of IGF-1R expression in relation to clinically relevant tumor characteristics. Methods: Expression of IGF-1R, insulin receptor, estrogen receptor (ER), progesterone receptor (PR), HER2 receptor, epidermal growth factor receptor and phosphorylated Akt (pAkt) was determined on tissue microarrays comprising primary invasive ductal breast carcinoma samples of a consecutive series of 221 patients. Patients presented at the University Medical Center Groningen between 1996 and 2001. Patient records were reviewed for clinical and tumor parameters. Cytoplasmic and membranous IGF-1R staining were scored separately, as the relevance of IGF-1R cellular localization is yet unknown. Associations were tested by Chi-square, Log Rank test and Cox regression analysis. Results: Overall, IGF-1R expression was present in 79% of the tumors. Cytoplasmic staining was present in 69%, membranous in 52%, staining was combined cytoplasmic and membranous in 42% of the tumors. Cytoplasmic, but not membranous, IGF-1R staining was associated with expression of ER (p<0.001), PR (p=0.001), pAkt (p=0.04), and increased relapse free and overall survival (RFS, p=0.01; OS, p=0.006). No correlations with other parameters were found. In ER/PR positive, HER2 negative tumors, but not in HER2 positive tumors, cytoplasmic IGF-1R expression correlated with increased RFS (p=0.002) and OS (p=0.001). In contrast, in triple negative tumors cytoplasmic and membranous expression of IGF-1R were both significantly associated with shorter RFS (p=0.02, p=0.04, resp.). In multivariate analysis, cytoplasmic IGF-1R expression was an independent prognostic factor for OS (HR 0.3, 95% CI 0.1–0.9, p=0.035). Conclusions: Cytoplasmic IGF-1R expression in invasive ductal breast carcinoma is associated with hormone receptor expression, phosphorylated Akt and good prognosis. Surprisingly, triple negative tumors expressing IGF-1R have a worse prognosis than those without. These results suggest that IGF-1R targeted therapy may have additional value in the treatment of triple negative tumors. No significant financial relationships to disclose.

scholarly journals Estrogen Receptor-β and the Insulin-Like Growth Factor Axis as Potential Therapeutic Targets for Triple-Negative Breast Cancer

2015 ◽  
Vol 20 (5-6) ◽  
pp. 373-390 ◽  
Author(s):  
Nalo Hamilton ◽  
Diana Marquez-Garban ◽  
Vei H. Mah ◽  
Yahya Elshimali ◽  
David Elashoff ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Growth Factor ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Therapeutic Targets ◽  
Estrogen Receptor Β ◽  
Insulin Like Growth Factor
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