scholarly journals Implementation of Protein Sequence Classification for Globin family using Ensemble Learnin

Feature Extraction from protein sequence is a very important task in bioinformatics. The main focus of that work is protein sequences classification that can be used to improve drug discovery and identification of diseases for treating patients in the early stages of diagnosis. In this paper, we proposed a method which is used for feature extraction i.e. converting the protein sequence of hemoglobin in to feature vectors. The feature vectors are then given to the ensemble classifier as an input which uses various classifier to provide better result/performance as compared to any constituent learning algorithm alone.

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Jiuwen Cao ◽  
Lianglin Xiong

Precisely classifying a protein sequence from a large biological protein sequences database plays an important role for developing competitive pharmacological products. Comparing the unseen sequence with all the identified protein sequences and returning the category index with the highest similarity scored protein, conventional methods are usually time-consuming. Therefore, it is urgent and necessary to build an efficient protein sequence classification system. In this paper, we study the performance of protein sequence classification using SLFNs. The recent efficient extreme learning machine (ELM) and its invariants are utilized as the training algorithms. The optimal pruned ELM is first employed for protein sequence classification in this paper. To further enhance the performance, the ensemble based SLFNs structure is constructed where multiple SLFNs with the same number of hidden nodes and the same activation function are used as ensembles. For each ensemble, the same training algorithm is adopted. The final category index is derived using the majority voting method. Two approaches, namely, the basic ELM and the OP-ELM, are adopted for the ensemble based SLFNs. The performance is analyzed and compared with several existing methods using datasets obtained from the Protein Information Resource center. The experimental results show the priority of the proposed algorithms.


2009 ◽  
Vol 16 (3) ◽  
pp. 457-474 ◽  
Author(s):  
Renqiang Min ◽  
Anthony Bonner ◽  
Jingjing Li ◽  
Zhaolei Zhang

2013 ◽  
Vol 14 (1) ◽  
pp. 96 ◽  
Author(s):  
Satish M Srinivasan ◽  
Suleyman Vural ◽  
Brian R King ◽  
Chittibabu Guda

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