Evaluation of toxicological profile of methanol leaf extract of Waltheria indica (Sterculiaceae)

Waltheria indica has been claimed to be used in managing several diseases in traditional medicine, although substantial scientific data are not available as regards its safety despite its pronounced efficacy in management of some ailments. Therefore, methanol leaf extract of W. indica was evaluated for its effects on some toxicological parameters using experimental animals. However, acute and sub-acute toxicity were carried out using experimental animals as described by standard methods. Absence of death reported after 24 hours of single oral administration of W. indica indicated that the crude drug is safe orally and the sample also had no effect on both hematological and biochemical parameters, with mild toxicity observed with some vital enzymes and organs upon continuous oral administration of W. indica for 21 days. However, it can be concluded that prolong usage of the plant for disease management should be discouraged, which implies that usage of the pant for short time usage in disease management.

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The Possibilities of Working Capacity Maintenance at Organophosphorous Compounds Intoxication

Journal of NBC Protection Corps ◽

10.35825/2587-5728-2019-3-4-311-318 ◽

2019 ◽

Vol 3 (4) ◽

pp. 311-318

Keyword(s):

Oral Administration ◽

Organophosphorus Compounds ◽

Working Capacity ◽

Industrial Accidents ◽

Experimental Animals ◽

Single Oral Administration ◽

Combined Use ◽

The World ◽

Organophosphorous Compounds ◽

Terrorist Acts

Th e experience of modern local armed confl icts and the monitoring of terrorist activity in the world indicate the possibility of the aff ection of people by organophosphorus compounds (OPs) in combat and as a result of industrial accidents and terrorist acts. It can be predicted that in case of timely use of PPE by the personnel, in addition to lethal and severe aff ections, up to 30 ± 5% of them will be mild forms of intoxication. It is shown in the article, that the actoprotectors with diff erent mechanism of action (hypoxene, octodrine and meldonium) increase the endurance of experimental animals with mild poisoning of OPs in case of single oral administration. Moreover, the degree of inhibition of peripheral blood acetylcholinesterase of all animals treated with model OPs did not diff er between groups and ranged from 8 to 24%. As a result of the experiments on animals, the preparations were distributed in the following order: meldonium <octodrine <hypoxene. Joint oral administration of the test substances was not accompanied by a potentiation of the actoprotective eff ect. It is established, that the combined use of the studied actoprotectors is comparable with the isolated administration of meldonium, has no advantages over the use of octodrine and surpasses hypoxene in rate of onset of the eff ect, but is inferior to it in severity and duration. Th ese facts indicate the viability of use of the studied actoprotectors to prevent a decrease in combat readiness in case of the threat of the aff ection by OPs (hypoxene), for its urgent increase in case of mild aff ection (octodrine) and for the complex treatment of poisoning due to organophosphates (OPs) (meldonium, hypoxene)

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