scholarly journals Leading role of the principles of interaction between the natural physical factors and integral organism in medicine of the future

2021 ◽  
Vol 2 (1) ◽  
pp. 085-105
Author(s):  
Vladimir Dodtievich Bitsoev
Keyword(s):  
Mechanism Of Action ◽  
Clinical Stage ◽  
Complete Information ◽  
Skin Surface ◽  
Intervertebral Discs ◽  
Scanning Tunneling ◽  
Tunnel Effect ◽  
Lumbosacral Spine ◽  
Physical Factors ◽  
Josephson Effects

The paper discusses the search of evidences of advantage of the physiotherapy over the drug therapy by the parameters and treatment methods according to clinical stage of a disease development, based on the results of labor medical examination and improvement of the quality of life. The above indicators were confirmed with a high statistical accuracy by example of a new rehabilitation technology: "Underwater horizontal spine traction with underwater phototherapy to solve an essential medical and social problem: treatment of patients with degenerative and dystrophic lesions of the lumbosacral spine with herniated protrusions of intervertebral discs, being one of the most common neurological pathologies worldwide. Based on the achievements in physics, i.e. discovery of "evanescent waves", "scanning tunneling microscope"; "AC and DC Josephson effects", development of highly sensitive equipment and discovery by the author of the present article of a highly informative, non-invasive, simple, harmless method of studying the mechanism of action of physical factors on the integral organism from any part of the skin surface, i.e. "blood spectrum biopsy" displaying the complete information picture of an organism, it became possible to create a new theory of a mechanism of action of physical factors on the supramolecular level of the integral organism on the principle of "tunnel effect".

Mod-5014, a Long-Acting FVIIa-CTP, Proposing a Novel Prophylactic Treatment Supporting Less Frequent Subcutaneous or Intravenous Injections with a Similar Mechanism of Action to rFVIIa: Proof-of-Concept in Hemophilic Animal Models

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 4670-4670 ◽  
Author(s):  
Lior Binder ◽  
Ahuva Bar-Ilan ◽  
Malka Hoffman ◽  
Gili Hart
Keyword(s):  
Mechanism Of Action ◽  
Half Life ◽  
Prophylactic Treatment ◽  
Conflicts Of Interest ◽  
Clinical Stage ◽  
Routes Of Administration ◽  
Hemostatic Effect ◽  
Long Acting

Abstract Introduction: OPKO Biologics is a clinical-stage public company developing bio-better long-acting versions of existing therapeutic proteins, utilizing a technology termed CTP. The technology involves fusion of the C-terminal peptide of hCG to a target protein. The aim of this work was to comprehensively assess the feasibility of intravenous (IV) or subcutaneous (SC) administration of FVIIa-CTP (MOD-5014) utilizing the most relevant in vivo pre-clinical models, and to characterize the FVIIa-CTP mechanism of action in preparation for an on-going clinical study. Methods: FVII-CTP was expressed in CHO cells, purified and activated utilizing a CTP-specific purification process. FVIIa-CTP's pharmacokinetics (PK), pharmacodynamics (PD), long-term hemostatic effect and safety parameters were extensively characterized following SC and IV administration in transient FVII-/- rats and FVIII-/- mice. In addition, the long-term hemostatic effect of FVIIa-CTP was evaluated following a bleeding challenge and compared to commercial rFVIIa. Finally, interaction with co-factors, activity, and the off-target effect of FVIIa-CTP was comprehensively characterized. Results: The studies demonstrated that FVIIa-CTP provides long-term exposure (AUC) and half-life that are significantly superior to those of rFVIIa, and consistent with the prolonged half-life of FVIIa-CTP (at an average of 3- and 5-fold, respectively) when compared to IV or SC administration of FVIIa. In addition, a 30% increase in bioavailability was observed relative to commercial FVIIa. A profound improvement in clotting parameters and survival rate following TVT, as well as a reduction of bleeding duration and intensity in tail-clip studies were obtained for both routes of administration for up to 48 hours. Moreover, the safety profile of FVIIa-CTP was further confirmed. Conclusion: Attachments of CTP to FVIIa led to a pronounced enhancement of PK and PD, increased exposure as reflected by AUC, elevated half-life, and improved recovery in mice, rats and pigs following SC and IV administration. FVIIa-CTP injection resulted in an improved bioavailability that translated to a marked in vivo hemostatic effect. Our data suggest that CTP-fused FVIIa can potentially provide a novel approach for IV or SC prophylactic treatment of hemophilic patients (both pediatric and adult), with the major benefit of significant improvement in quality of life. Disclosures No relevant conflicts of interest to declare.

A Model for Lattice-Mismatched Epitaxy: A Continuum View

1992 ◽  
Vol 280 ◽  
Author(s):  
B. G. Orr ◽  
C. W. Snyder
Keyword(s):  
Surface Diffusion ◽  
Strain Relaxation ◽  
Relaxation Mechanism ◽  
High Energy ◽  
Growth Mode ◽  
Scanning Tunneling ◽  
Physical Factors ◽  
Diffusion Kinetics ◽  
Tunneling Microscopy ◽  
Lattice Mismatched Epitaxy

To date, primarily only idealized equilibrium models for the growth mode and strain relaxation of elastically strained overlayers have been proposed. Here we present a general continuum model for lattice-mismatched epitaxy. As molecular beam epitaxy is inherently a nonequilibrium growth process, surface diffusion kinetics is incorporated in the model. Additionally, a new strain relaxation mechanism in a dislocation-free film is considered. Experimental support for our view is obtained from measurements made by reflection high energy electron diffraction, scanning tunneling microscopy, and transmission electron microscopy on the growth of InGaAs on GaAs(100). These results demonstrate the strong effects which strain, surface diffusion kinetics, and surface energy have on growth mode. From analytical and numerical analysis in 1 + 1 dimensions, the interrelationship of such physical factors is revealed. Our improved understanding enables control over the growth behavior of strained-layer superlattices and heterostructures.

scholarly journals Mammalian spinal biomechanics. I. Static and dynamic mechanical properties of intact intervertebral joints.

1993 ◽  
Vol 174 (1) ◽  
pp. 247-280 ◽  
Author(s):  
J M Gál
Keyword(s):  
Meles Meles ◽  
Dynamic Mechanical Properties ◽  
Intervertebral Discs ◽  
Ovis Aries ◽  
Lumbosacral Spine ◽  
Panthera Tigris ◽  
Scaling Effects ◽  
Four Point Bending ◽  
Angular Change ◽  
Pure Extension

Four-point bending was used to apply pure extension and flexion moments to the ligamentous lumbosacral spine and pelvic girdle of monkey (Macaca fascicularis), rabbit (domestic and wild, Oryctolagus cuniculus), badger (Meles meles), wallaby (Wallabia rufogrisea frutica), sheep (Ovis aries), seal (Phoca vitulina) and tiger (Panthera tigris). The absolute ranges of angular change in lumbar-lumbar joints (from X-radiographs) were considerable and similar in monkey and wallaby (greater in flexion) and in rabbit and badger (symmetrical in extension and flexion). Mass-specific bending comparisons showed that monkey and seal joints were the most and least resistant, respectively, to these moments. The patterns of mobility showed no clear scaling effects. Subsequently, additional ligamentous joint complexes (three vertebrae and two intervertebral discs) of monkey, wallaby, tiger, jaguar (Panthera onca) and seal (Halichoerus grypus) were subjected to cyclic extension and flexion moments. Changes in intervertebral angle (y, from X-radiographs) were modelled as functions of applied specific bending moments (x):y=A(1-e-Bx). A and B values represented bending capacities and joint compliances respectively. Homologous monkey and wallaby joints had considerable flexion capacities, with low compliances. Homologous jaguar and tiger joints had limited flexion capacities, but greater compliances. The data suggest that flexion resistance may be controlled by different mechanisms in different species.

The Distribution of Calcific Deposits in Intervertebral Discs of the Lumbosacral Spine

1990 ◽  
Vol &NA; (254) ◽  
pp. 303???310 ◽  
Author(s):  
JOSEPH FEINBERG ◽  
OHENEBA BOACHIE-ADJEI ◽  
PETER G. BULLOUGH ◽  
ADELE L. BOSKEY
Keyword(s):  
Intervertebral Discs ◽  
Lumbosacral Spine ◽  
Calcific Deposits

scholarly journals Closed spinal dysraphism in a 6-month-old mixed breed dog

2021 ◽  
Author(s):  
GG Franco ◽  
EGM Siqueira ◽  
JAL Souza ◽  
LOC Prado ◽  
SC Rahal ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Spinal Cord ◽  
Magnetic Resonance ◽  
Spinal Dysraphism ◽  
Skin Surface ◽  
Lumbosacral Spine ◽  
Resonance Imaging ◽  
Mixed Breed ◽  
Spinal Cord Segment ◽  
Dorsal Laminectomy

The term spinal dysraphism defines an incomplete fusion or a bone defect that affects the neural structures of the spinal cord due to a neural tube malformation. A 6-month-old, male, mixed-breed dog, was evaluated for paraparesis, pelvic limb proprioceptive ataxia, faecal and urinary incontinence. A neurological examination indicated an L4-S3 spinal cord segment lesion. A thoracolumbar and lumbosacral spine magnetic resonance imaging was performed and a closed spinal dysraphism, with the presence of a lipomyelomeningocele, was detected. The magnetic resonance imaging showed an entire narrowing passage and a fibrous mass stemming from a wedge-shaped gap in the caudal region of the dorsal lamina of the L4 vertebra, leaving the spinal canal towards the skin surface in the region where the skin stigma was observed. A dorsal laminectomy was performed, the spinal cord was exposed, and the entire fibrous mass was excised. Three months postoperatively, the patient had a complete resolution of the urinary and faecal incontinence showing only a residual mild paraparesis, which remained six months after surgery. The surgical procedure resulted in the satisfactory recovery of the neurological signs.

Evaluation of dynamic MRI data in patients with herniated intervertebral discs after the complex treatment including osteopathic correction

2021 ◽  
pp. 60-68
Author(s):  
S. M. Adrianova ◽  
B. H. Akhmetov
Keyword(s):  
Dynamic Mri ◽  
Intervertebral Discs ◽  
Small Sample ◽  
Medical Attention ◽  
Lumbosacral Spine ◽  
Complex Treatment ◽  
Lumbosacral Region ◽  
Therapy Effect ◽  
Magnetic Resonance Imaging Mri ◽  
Hernia Size

Introduction. Pain in the lumbosacral region is one of the most common causes of disability and medical attention acquiring. Magnetic resonance imaging (MRI) of the spine in these patients quite often demonstrates multiple hernias. Despite the success of modern, including complex, methods of treating patients with herniated discs of lumbosacral spine, the problem of objective revealing of the applied therapy effect with modern instrumental examination methods is actual.The goal of research — study was to study the changes in the MRI picture in patients with herniated intervertebral discs during treatment with inclusion of osteopathic correction.Materials and methods. The study involved 15 patients with herniated intervertebral discs of lumbosacral spine. The patients received outpatient conservative treatment with inclusion of osteopathic correction. Participants underwent MRI of the lumbar spine at the beginning of the study and 3 months after treatment. The obtained data were processed by methods of nonparametric statistics.Results. After the complex treatment, such indicators of MRI as the hernia size, the lateral pocket width and the pelvis configuration significantly improved. These parameters are important indicators of pathomorphological changes in the spinal motion segment, affecting the discoradicular conflict. At the same time, there were no obtained convincing data about the therapy effect on the L5 vertebra rotation, on the presence of sequestration and changes in the Tchaikovsky index. Perhaps this is due to the small sample and short follow-up period for patients.Conclusion. After the course of treatment with inclusion of osteopathic correction, the statistically significant changes in MRI images were revealed in patients with herniated intervertebral discs, indicating a positive dynamics in the parameters of the hernia size, the width of the lateral pocket and the configuration of the pelvis.

Postoperative applications of the fast track technology in patients with herniated intervertebral discs of the lumbosacral spine

2016 ◽  
Vol 80 (4) ◽  
pp. 5 ◽  
Author(s):  
A. G. Nazarenko ◽  
N. A. Konovalov ◽  
A. V. Krut’ko ◽  
T. N. Zamiro ◽  
I. B. Geroeva ◽  
...  
Keyword(s):  
Fast Track ◽  
Intervertebral Discs ◽  
Lumbosacral Spine

Balneotherapy and Physiotherapy in Chronic Pain Syndrome of the Lumbosacral Spine. Review of the literature

2020 ◽  
Vol 62 (2) ◽  
pp. 119-126
Author(s):  
Anna Zduńska ◽  
Sebastian Zduński ◽  
Katarzyna Nowicka ◽  
Agnieszka Rudnicka
Keyword(s):  
Back Pain ◽  
Pain Syndrome ◽  
Intervertebral Discs ◽  
Common Disease ◽  
Lumbosacral Spine ◽  
Health Resort ◽  
Important Place ◽  
Pain Disability ◽  
Pain Syndromes

Back pain is a common disease and although it can be located in any of its cervical, thoracic and lumbosacral sections, however the vast majority of patients complain of lumbosacral pain. Back pain syndromes has become a challenge for modern rehabilitation, both in the issue of the prevention as well as therapy. A major problem for people with back pain is progressive disability, and thus a deterioration in the quality of life. Despite many treatment methods and health care resources devoted to back pain, disability and burden are increasing. An important place in the therapy of back pain syndromes is occupied by physical methods and health resort treatment. The work presents the use of balneotherapy and physiotherapy in the most common back pain syndromes, i.e. in chronic diseases of the intervertebral discs and degenerative changes of the lumbosacral spine.

Stepwise Validated Finite Element Model of the Human Lumbar Spine

2013 ◽  
Author(s):  
Dana Coombs ◽  
Michael Bushelow ◽  
Peter Laz ◽  
Milind Rao ◽  
Paul Rullkoetter
Keyword(s):  
Soft Tissues ◽  
Element Model ◽  
Intervertebral Discs ◽  
Lumbosacral Spine ◽  
Fe Model ◽  
Human Lumbar Spine ◽  
Spine Mechanics ◽  
Structural Configurations ◽  
The Individual

Understanding the kinematics of the lumbosacral spine and the individual functional spinal units (FSU) is essential in assessing spine mechanics and implant performance. The lumbosacral spine and the FSU are comprised of bones and complex soft tissues such as intervertebral discs (IVD) and ligaments. Prior studies have focused on the behavior of isolated structures, but the contribution of each structure to the overall kinematics of the spine needs to be further understood. In this study, the behavior of various structural conditions was determined by experimentally dissecting each ligament in a stepwise fasion until only the IVD remained, and applying loading conditions to the FSU. The FE model was validated through optimization to match the in vitro load-deflection characteristics and contact mechanics for the various structural configurations.

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