scholarly journals Determination of renal blood flow with Doppler ultrasound and the hypertension prevalence and acid-base level in dogs with chronic renal failure

2019 ◽  
pp. 6-12
Author(s):  
Lora Koenhemsi ◽  
Remzi Gönül
Keyword(s):  
Renal Failure ◽  
Blood Flow ◽  
Chronic Renal Failure ◽  
Renal Blood Flow ◽  
Doppler Ultrasound ◽  
Acid Base ◽  
Hypertension Prevalence ◽  
Base Level

COMPARATIVE CHARACTERISTICS OF RENAL BLOOD FLOW IN PATIENTS WITH CHRONIC RENAL FAILURE DEVELOPED AS A RESULT OF MYELOMA NEPHROPATHY AND IN PRIMARY NEPHROLOGY PATHOLOGY

2016 ◽  
Vol 1 (62) ◽  
pp. 53-58
Author(s):  
Наталья Макарова ◽  
Natalya Makarova
Keyword(s):  
Multiple Myeloma ◽  
Renal Failure ◽  
Blood Flow ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Flow Velocity ◽  
Renal Blood Flow ◽  
Vascular Resistance ◽  
Mean Flow ◽  
Myeloma Nephropathy

A comparative analysis of the indicators of renal hemodynamics in patients with chronic renal failure/chronic kidney disease (CRF/CKD) developed against myeloma nephropathy (group 1) and with primary kidney disease (group 2) was done. 20 patients were included in the first group, 14 patients were in the second one, and in most cases there was Stage 3 CRF/CKD. There were analyzed the following indicators of renal blood flow: peak systolic velocity, end diastolic velocity, mean flow velocity throughout the entire cardiac cycle, resistive index and pulsation index. Circulation figures were recorded at the level of basic, segmental, interlobar, arc, interlobular renal arteries. It is concluded that violations of renal blood flow and vascular resistance in patients with multiple myeloma complicated by chronic renal failure are primarily due to CKD itself. The differences in the two groups of patients with CRF/CKD were only about the average level in the parenchymal blood flow velocity (interlobular, arcuate, interlobar arteries); at myeloma nephropathy it was significantly reduced in comparison with the control group and patients with CRF/CKD without hemoblastosis. The rest velocity parameters were significantly reduced and vascular resistance indices were increased in comparison with the control and did not differ in groups of patients with CRF/CKD. Thus, hemodynamic changes at the level of parenchyma are the most important for patients with multiple myeloma, which suggests more severe violations of kidneys in these patients with the complication of CRF.

High-NaCl diet impairs dynamic renal blood flow autoregulation in rats with adenine-induced chronic renal failure

2014 ◽  
Vol 306 (6) ◽  
pp. R411-R419 ◽  
Author(s):  
Aso Saeed ◽  
Gerald F. DiBona ◽  
Elisabeth Grimberg ◽  
Lisa Nguy ◽  
Minne Line Nedergaard Mikkelsen ◽  
...  
Keyword(s):  
Renal Failure ◽  
Blood Flow ◽  
Chronic Renal Failure ◽  
Arterial Pressure ◽  
Renal Blood Flow ◽  
Low Frequency ◽  
Organ Injury ◽  
Myogenic Response ◽  
Frequency Range ◽  
Renal Blood Flow Autoregulation

This study examined the effects of 2 wk of high-NaCl diet on kidney function and dynamic renal blood flow autoregulation (RBFA) in rats with adenine-induced chronic renal failure (ACRF). Male Sprague-Dawley rats received either chow containing adenine or were pair-fed an identical diet without adenine (controls). After 10 wk, rats were randomized to either remain on the same diet (0.6% NaCl) or to be switched to high 4% NaCl chow. Two weeks after randomization, renal clearance experiments were performed under isoflurane anesthesia and dynamic RBFA, baroreflex sensitivity (BRS), systolic arterial pressure variability (SAPV), and heart rate variability were assessed by spectral analytical techniques. Rats with ACRF showed marked reductions in glomerular filtration rate and renal blood flow (RBF), whereas mean arterial pressure and SAPV were significantly elevated. In addition, spontaneous BRS was reduced by ∼50% in ACRF animals. High-NaCl diet significantly increased transfer function fractional gain values between arterial pressure and RBF in the frequency range of the myogenic response (0.06–0.09 Hz) only in ACRF animals (0.3 ± 4.0 vs. −4.4 ± 3.8 dB; P < 0.05). Similarly, a high-NaCl diet significantly increased SAPV in the low-frequency range only in ACRF animals. To conclude, a 2-wk period of a high-NaCl diet in ACRF rats significantly impaired dynamic RBFA in the frequency range of the myogenic response and increased SAPV in the low-frequency range. These abnormalities may increase the susceptibility to hypertensive end-organ injury and progressive renal failure by facilitating pressure transmission to the microvasculature.

PAH extraction and estimation of plasma flow in human postischemic acute renal failure

1999 ◽  
Vol 277 (2) ◽  
pp. F312-F318 ◽  
Author(s):  
Geraldine Corrigan ◽  
Deepa Ramaswamy ◽  
Osun Kwon ◽  
F. Graham Sommer ◽  
Edward J. Alfrey ◽  
...  
Keyword(s):  
Renal Failure ◽  
Blood Flow ◽  
Acute Renal Failure ◽  
Renal Blood Flow ◽  
Plasma Flow ◽  
Renal Allograft ◽  
Renal Plasma Flow ◽  
Pah Clearance ◽  
Normal Controls

We determined the effect of postischemic injury to the human renal allograft on p-aminohippurate (PAH) extraction (EPAH) and renal blood flow. We evaluated renal function in 44 allograft recipients on two occasions: 1–3 h after reperfusion ( day 0) and again on postoperative day 7. On day 0 subsets underwent intraoperative determination of renal blood flow ( n = 35) by Doppler flow meter and EPAH( n = 25) by renal venous assay. Blood flow was also determined in another subset of 16 recipients on postoperative day 7 by phase contrast-cine-magnetic resonance imaging, and EPAH was computed from the simultaneous PAH clearance. Glomerular filtration rate (GFR) on day 7 was used to divide subjects into recovering ( n = 23) and sustained ( n = 21) acute renal failure (ARF) groups, respectively. Despite profound depression of GFR in the sustained ARF group, renal plasma flow was only slightly depressed, averaging 296 ± 162 ml ⋅ min−1 ⋅ 1.73 m−2 on day 0 and 202 ± 72 ml ⋅ min−1 ⋅ 1.73 m−2 on day 7, respectively. These values did not differ from corresponding values in the recovering ARF group: 252 ± 133 and 280 ± 109 ml ⋅ min−1 ⋅ 1.73 m−2, respectively. EPAH was profoundly depressed on day 0, averaging 18 ± 14 and 10 ± 7% in recovering and sustained ARF groups, respectively, vs. 86 ± 6% in normal controls ( P < 0.001). Corresponding values on day 7remained significantly depressed at 65 ± 20 and 11 ± 22%, respectively. We conclude that postischemic injury to the renal allograft results in profound impairment of EPAH that persists for at least 7 days, even after the onset of recovery. An ensuing reduction in urinary PAH clearance results in a gross underestimate of renal plasma flow, which is close to the normal range in the initiation, maintenance, and recovery stages of this injury.

scholarly journals Endothelin-A Receptor Antagonism Reduces Blood Pressure and Increases Renal Blood Flow in Hypertensive Patients With Chronic Renal Failure

Circulation ◽  
2004 ◽  
Vol 109 (9) ◽  
pp. 1186-1193 ◽  
Author(s):  
Jane Goddard ◽  
Neil R. Johnston ◽  
Malcolm F. Hand ◽  
Allan D. Cumming ◽  
Ton J. Rabelink ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Blood Flow ◽  
Chronic Renal Failure ◽  
Renal Blood Flow ◽  
Hypertensive Patients ◽  
Receptor Antagonism ◽  
Endothelin A Receptor ◽  
Endothelin A

Determination of renal blood flow by thermodilution method

1978 ◽  
Vol 38 (5) ◽  
pp. 495-499 ◽  
Author(s):  
Torbjörn Leivestad ◽  
Erling Brodwall ◽  
Svein Simonsen
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Thermodilution Method

scholarly journals Extraction Methods for the Determination of Regional Renal Blood Flow

1979 ◽  
Vol 84 (2) ◽  
pp. 163-171 ◽  
Author(s):  
A.-C. Ericson ◽  
M. Sjöquist ◽  
H. R. Ulfendahl
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Extraction Methods ◽  
Regional Renal Blood Flow

Measurement of Intrarenal Blood-Flow Distribution in the Rabbit Using Radioactive Microspheres

1975 ◽  
Vol 48 (1) ◽  
pp. 51-60 ◽  
Author(s):  
D. J. Warren ◽  
J. G. G. Ledingham
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Renal Cortex ◽  
Flow Distribution ◽  
Rabbit Kidney ◽  
Radioactive Microspheres ◽  
Injection Dose ◽  
Intrarenal Blood Flow ◽  
Total Renal Blood Flow

1. Total renal blood flow and its distribution within the renal cortex of the conscious rabbit were studied with radioactive microspheres of 15 and 25 μm diameter. 2. The reliability of the microsphere technique was influenced by microsphere diameter and number (dose). The optimum microsphere diameter for determination of flow distribution in the rabbit kidney was 15 μm and dose 100–150 000 spheres. 3. Spheres of 15 μm nominal diameter were randomly distributed within the renal cortex of adult rabbits. The larger spheres in batches nominally 15 μm in diameter in young rabbits and 25 μm diameter in adult rabbits were preferentially distributed to the superficial cortex. 4. In adult rabbits 15 μm diameter spheres lodged in glomerular capillaries. Larger spheres occasionally lodged in interlobular arteries causing intrarenal haemorrhage. 5. Microspheres of 15 μm caused a decrease in renal clearance of creatinine and of p-aminohippurate when the total injection dose was about 200 000 spheres. These effects were greater when the injection dose was increased to 500 000 spheres. 6. The reduction in total renal blood flow observed with large doses of spheres largely reflected decreased outer cortical flow, as measured by a second injection of spheres, and confirmed by a decrease in p-aminohippurate extraction. 7. The reproducibility of multiple injection studies was limited by these intrarenal effects of microspheres. 8. Total renal blood flow measured in six rabbits in acute experiments by the microsphere technique was 107 ± 12 (mean±sd) ml/min and by p-aminohippurate clearance was 100 ± 10 ml/min. 9. Total renal blood flow in twelve conscious, chronically instrumented rabbits was 125 ± 11 ml/min, of which 92 ± 6 ml/min was distributed to the superficial cortex and 33 ± 4 ml/min to the deep cortex.

scholarly journals Determination of Radical Species in the Kidney of Rats with Chronic Renal Failure by the Spin Trapping Method

Nephron ◽  
1995 ◽  
Vol 70 (3) ◽  
pp. 382-384 ◽  
Author(s):  
Takako Yokozawa ◽  
Naoki Fujitsuka ◽  
Hikokichi Oura ◽  
Akitane Mori ◽  
Hiroshi Kashiwagi
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Spin Trapping ◽  
Radical Species ◽  
Trapping Method

scholarly journals Dissociation of glomerular filtration and renal blood flow in HgCl2-induced acute renal failure

1982 ◽  
Vol 22 (2) ◽  
pp. 162-170 ◽  
Author(s):  
Raymond C. Vanholder ◽  
Marleen M. Praet ◽  
Piet A. Pattyn ◽  
Isidoor R. Leusen ◽  
Norbert H. Lameire
Keyword(s):  
Renal Failure ◽  
Blood Flow ◽  
Acute Renal Failure ◽  
Glomerular Filtration ◽  
Renal Blood Flow
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