DEVELOPMENT AND EVALUATION OF GEL CONTAINING PHOSPHATIDYLCHOLINE COMPLEXES OF ARBUTIN AND CURCUMIN AS SKIN WHITENING AGENT

2021 ◽  
Vol 10 (10) ◽  
Keyword(s):  
Skin Whitening ◽  
Whitening Agent

scholarly journals AKTIVITAS DARI KUERSETIN SEBAGAI AGEN PENCERAH KULIT SECARA IN SILICO

Jurnal Kimia ◽  
2019 ◽  
pp. 207
Author(s):  
K. D. Adnyani ◽  
L. W. E. Lestari ◽  
H. Prabowo ◽  
P. A. I. A. Siaka ◽  
N. P. L. Laksmiani
Keyword(s):  
Molecular Docking ◽  
Binding Energy ◽  
In Silico ◽  
Target Protein ◽  
Related Protein ◽  
Skin Whitening ◽  
Whitening Agent ◽  
Docking Method ◽  
Tyrosinase Related Protein ◽  
Molecular Docking Method

Increasing melanogenesis process causes excessive melanin synthesis resulting in darkening of the skin color. The melanogenesis process requires mealnogenesis enzymes, one of which is tyrosinase-related protein 1. One of the flavonoid compounds that has the potential as a skin lightening agent is quercetin. The antioxidant activity of quercetin plays a very important role in antimelanogenesis. This study aims to determine the affinity and molecular mechanism of quercetin on the target protein tyrosinase-related protein 1 using in silico molecular docking method. Molecular docking is carried out through stages including optimization of the structure of quercetin compounds, preparation of the target protein tyrosinase-related protein 1, validation of the molecular docking method, and docking of quercetin on the tyrosinase-related protein 1. Docking of quercetin with tyrosinase-related protein 1 produces binding energy values of -7.81 kcal/mol, while docking of native ligand with tyrosinase-related protein 1 produces binding energy values of -5.39 kcal/mol. Quercetin has a strong affinity for tyrosinase-related protein 1 which is indicated by the binding energy from the docking results. Quercetin has activity as a skin whitening agent with in silico test with molecular mechanisms through inhibition of the activity of tyrosinase-related protein 1 enzyme.  Keywords: skin whitening agent, in silico, quercetin, tyrosinase-related protein 1

P-Protein: A Novel Target for Skin-whitening Agent

2019 ◽  
Vol 24 (1) ◽  
pp. 76-84
Author(s):  
Birendra Kumar Singh ◽  
Eun-Ki Kim
Keyword(s):  
Protein A ◽  
Skin Whitening ◽  
Whitening Agent ◽  
P Protein ◽  
Novel Target

Experimental and theoretical charge density analysis of skin whitening agent kojic acid

2020 ◽  
Vol 1216 ◽  
pp. 128295
Author(s):  
Asma Hasil ◽  
Arshad Mehmood ◽  
Sajida Noureen ◽  
Maqsood Ahmed
Keyword(s):  
Charge Density ◽  
Kojic Acid ◽  
Skin Whitening ◽  
Whitening Agent ◽  
Density Analysis

scholarly journals Antioxidant and Antimelanogenesis Activities of Glyasperin A From Macaranga pruinosa Leaves

2019 ◽  
Vol 14 (7) ◽  
pp. 1934578X1986719 ◽  
Author(s):  
Enos T. Arung ◽  
Jhonner R. Sinamabela ◽  
Enih Rosamah ◽  
Irawan W. Kusuma ◽  
Harlinda Kuspradini ◽  
...  
Keyword(s):  
Natural Resources ◽  
Enzyme Assay ◽  
Spectroscopic Analysis ◽  
Analysis Data ◽  
B16 Melanoma ◽  
Leaf Extracts ◽  
Skin Whitening ◽  
Whitening Agent ◽  
Tyrosinase Enzyme ◽  
Macaranga Tanarius

In our effort to find materials for drugs and cosmetics from tropical natural resources, we screened 21 methanol extracts from 7 Macaranga trees species ( Macaranga bancana, Macaranga gigantea, Macaranga hulle ttii, Macaranga pruinosa, Macaranga tanarius, Macaranga trichocarpa, and Macaranga triloba) for antioxidant and antimelanogenesis. The antioxidant and melanogenesis (tyrosinase enzyme assay and melanin inhibitor in B16 melanoma) assays were used to determine the activities. The fractionation and the isolation of active compound were done by various chomatographic methods and the structure was determined by spectroscopic analysis data. We isolated a prenylated flavonoid, named Glyasperin A, from M. pruinosa leaf. This compound showed a potency as antioxidant and inhibited melanin in B16 melanoma but not tyrosinase activity. These results showed that the methanol leaf extracts of M. pruinosa could be developed for cosmetic applications especially as a skin whitening agent.

Understanding the role of extracts from sea buckthorn seed residues in anti-melanogenesis properties on B16F10 melanoma cells

2018 ◽  
Vol 9 (10) ◽  
pp. 5402-5416 ◽  
Author(s):  
Jiachan Zhang ◽  
Changtao Wang ◽  
Chengtao Wang ◽  
Baoguo Sun ◽  
Cai Qi
Keyword(s):  
Melanoma Cells ◽  
Sea Buckthorn ◽  
Hippophae Rhamnoides ◽  
B16f10 Melanoma ◽  
Hydroalcoholic Extract ◽  
Skin Whitening ◽  
Hippophaë Rhamnoides ◽  
Whitening Agent ◽  
B16f10 Melanoma Cells

The hydroalcoholic extract of sea buckthorn (Hippophae rhamnoides L.) seed residues (HYD-SBSR) is a potential skin whitening agent.

scholarly journals Search for Skin-whitening Agent from Prunus Plants and the Molecular Targets in Melanogenesis Pathway of Active Compounds

2014 ◽  
Vol 9 (2) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Kazuya Murata ◽  
Keisuke Takahashi ◽  
Haruka Nakamura ◽  
Kimihisa Itoh ◽  
Hideaki Matsuda
Keyword(s):  
Research Program ◽  
Molecular Targets ◽  
Molecular Target ◽  
The Novel ◽  
Tyrosinase Inhibition ◽  
Prunus Species ◽  
Skin Whitening ◽  
Whitening Agent ◽  
First Time ◽  
Potent Inhibitory Activity

In our research program for discovering novel skin-whitening materials, screening of extracts from flowers of some Prunus species was performed using an anti-tyrosinase assay. Among the tested plants, the flowers of P. persica showed the most potent inhibitory activity. In addition, P. persica also showed suppression of melanogenesis in B16 rat melanoma cells. The active principles of tyrosinase inhibition and suppression of melanogenesis were revealed to be an afzelin (3- O-α-L-rhamnosylkaempferol) and a flavanone, naringenin. The mechanism of the anti-melanogenesis effect of these two compounds was disclosed, for the first time, as the suppression of the expression of tyrosinase protein, which was controlled by the inhibition of phosphorylation of p38 MAPK. These findings show that these compounds could be candidates for the novel molecular target for a skin-whitening agent.

Sign in / Sign up

Export Citation Format

Share Document