scholarly journals Prognostic value of cyclin D1 expression in tumor-free surgical margins in head and neck squamous cell carcinomas

2013 ◽  
Vol 133 (9) ◽  
pp. 984-991 ◽  
Author(s):  
Tomohiro Sakashita ◽  
Akihiro Homma ◽  
Seigo Suzuki ◽  
Hiromitsu Hatakeyama ◽  
Satoshi Kano ◽  
...  
2006 ◽  
Vol 79 (3) ◽  
pp. 288-297 ◽  
Author(s):  
Ruth A. Jonathan ◽  
Karien I.E.M. Wijffels ◽  
Wenny Peeters ◽  
Peter C.M. de Wilde ◽  
Henri A.M. Marres ◽  
...  

Oncotarget ◽  
2015 ◽  
Vol 6 (27) ◽  
pp. 24002-24016 ◽  
Author(s):  
Yu-Chao Chang ◽  
Chia-Ing Jan ◽  
Chih-Yu Peng ◽  
Yu-Chi Lai ◽  
Fang-Wei Hu ◽  
...  

2015 ◽  
Vol 30 (3) ◽  
pp. 217-224 ◽  
Author(s):  
Tsuneo Saga ◽  
Masayuki Inubushi ◽  
Mitsuru Koizumi ◽  
Kyosan Yoshikawa ◽  
Ming-Rong Zhang ◽  
...  

2002 ◽  
Vol 198 (8) ◽  
pp. 509-515 ◽  
Author(s):  
Constanze Ondruschka ◽  
Peter Buhtz ◽  
Christiane Motsch ◽  
Bernd Freigang ◽  
Regine Schneider-Stock ◽  
...  

2014 ◽  
Vol 273 (4) ◽  
pp. 801-809 ◽  
Author(s):  
Federico M. Gioacchini ◽  
Matteo Alicandri-Ciufelli ◽  
Shaniko Kaleci ◽  
Giuseppe Magliulo ◽  
Livio Presutti ◽  
...  

2021 ◽  
Vol 6 (2) ◽  
pp. 99-104
Author(s):  
P Sakthidasan Chinnathambi ◽  
Deepak Kumar B

Squamous cell carcinomas constitute 95% of cancers of the head and neck region. The progression of disease in these patients depends on various molecular regulators. The present study is undertaken to identify the immunoexpression of Cyclin D1 in Head and Neck Squamous Cell Carcinomas (HNSCC) and to study their association with clinicopathological variables in routine diagnostics.1. To study the expression of Cyclin D1 in Head and Neck Squamous Cell Carcinomas by immunohistochemistry. 2. To correlate the expression of Cyclin D1 with histopathological grading and various demographic parameters.150 cases of HNSCCs were studied for a period of 18 months in ESIC MC & PGIMSR, Bangalore. The cases were subjected to immunohistochemical analysis of Cyclin D1 antigen. Immunoexpression of Cyclin D1 was correlated with histopathological differentiation and clinical parameters.Out of 150 cases; well, moderate and poorly differentiated grades constituted67, 63 and 20 cases respectively. Immunoexpression of Cyclin D1 wasfound in 100 % of the cases and they were significantly associated with worseninggrade of the tumour and positive lymph node disease while it was not found to be associated with other clinical parameters.Immunohistochemical analysis of cyclin D1 can be routinely done inHNSCC as it proves to be an effective, early prognostic indicator in predicting theadvanced stage of the disease and guiding appropriate management.


2016 ◽  
Vol 24 (7) ◽  
pp. 476-481 ◽  
Author(s):  
Kornél Dános ◽  
Diána Brauswetter ◽  
Ede Birtalan ◽  
Anna Pató ◽  
Gabriella Bencsik ◽  
...  

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