Colonization by haemophilus influenzae and group a streptococci in recurrent acute tonsillitis and in tonsillar hypertrophy

1990 ◽  
Vol 109 (3-4) ◽  
pp. 314-319 ◽  
Author(s):  
Anna Stjernquist-Desatnik ◽  
Karin Prellner ◽  
Claes Schalén
Keyword(s):  
Haemophilus Influenzae ◽  
Group A Streptococci ◽  
Tonsillar Hypertrophy ◽  
Acute Tonsillitis ◽  
Group A

High recovery ofHaemophilus influenzaeand group A streptococci in recurrent tonsillar infection or hypertrophy as compared with normal tonsils

1991 ◽  
Vol 105 (6) ◽  
pp. 439-441 ◽  
Author(s):  
A. Stjernquist-Desatnik ◽  
K. Prellner ◽  
C. Schalén
Keyword(s):  
Sleep Apnoea ◽  
Group A Streptococci ◽  
Tonsillar Hypertrophy ◽  
Isolation Rate ◽  
High Recovery ◽  
Acute Tonsillitis ◽  
Core Recovery ◽  
History Of ◽  
Group A ◽  
Normal Controls

AbstractOne hundred and twenty-six patients who underwent tonsillectomy because of recurrent acute tonsillitis, tonsillar hypertrophy or sleep apnoea were evaluated by tonsillar core culturing. The sleep apnoea patients served as controls, since none of them had tonsillar hypertrophy at ENT examination or any history of recurrent acute tonsillitis, and thus their tonsillar core flora could be regarded as normal.The isolation rate ofH. influenzaewas much lower among sleep apnoea controls (2.7 per cent) than among either the patients with recurrent acute tonsillitis (20.3 per cent) or those with tonsillar hypertrophy (36.7 per cent) (p<0.05), as was that of group A streptococci, 5.4 per centversus16.9 and 20 per cent, respectively (though the latter differences were not statistically significant). The isolation frequencies ofB. catarrhalis, pneumococci, group C and G streptococci did not differ between the three groups.The high tonsillar core recovery rates ofH. influenzaeand group A streptococci both in patients with recurrent acute tonsillitis and in those with tonsillar hypertrophy, as compared with normal controls, suggests the possible involvement of these bacteria in both conditions.

In vivo Attachment of Group a Streptococci to Tonsillar Epithelium during Acute Tonsillitis

1991 ◽  
Vol 23 (3) ◽  
pp. 309-313 ◽  
Author(s):  
Lars-Eric Stenfors ◽  
Simo Räisänen ◽  
Immo Rantala
Keyword(s):  
Group A Streptococci ◽  
Acute Tonsillitis ◽  
Group A

scholarly journals Toll-Like Receptor 4 Gene (TLR4), but NotTLR2, Polymorphisms Modify the Risk of Tonsillar Disease Due toStreptococcus pyogenesandHaemophilus influenzae

2010 ◽  
Vol 18 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Kyriaki Liadaki ◽  
Efthimia Petinaki ◽  
Charalampos Skoulakis ◽  
Paraskeui Tsirevelou ◽  
Dimitra Klapsa ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Receptor Gene ◽  
Toll Like Receptor ◽  
Bacterial Strains ◽  
Tonsillar Hypertrophy ◽  
Recurrent Tonsillitis ◽  
Beta Hemolytic Streptococcus ◽  
Increased Risk ◽  
Human Disorders ◽  
Group A

ABSTRACTTonsillar disease (recurrent tonsillitis and/or tonsillar hypertrophy) is one of the most common human disorders, withStreptococcus pyogenes(group A beta-hemolytic streptococcus [GAS]) andHaemophilus influenzaerepresenting the most common pathogens. Until now, no study has investigated why some individuals are more susceptible to tonsillar infections caused by specific bacteria than others. The aim of this study was to uncover possible associations between common Toll-like receptor gene (TLR) polymorphisms and tonsillar disease. TheTLR2-R753Q,TLR4-D299G, andTLR4-T399I polymorphisms were determined in a cohort of 327 patients subjected to tonsillectomy due to recurrent tonsillitis (n= 245) and tonsillar hypertrophy (n= 82) and 245 healthy bone marrow donors. Associations of the aforementioned polymorphisms with the isolated bacterial strains after tonsillectomy were also investigated. Interestingly, carriers of theTLR4polymorphisms displayed an approximately 3-fold increased risk for GAS infections (forTLR4-D299G, odds ratio [OR] = 2.81, 95% confidence interval [CI] = 1.16 to 6.79,P= 0.038; forTLR4-T399I, OR = 3.01, 95% CI = 1.29 to 7.02,P= 0.023), and this association was more profound in patients with recurrent tonsillitis. On the contrary, the presence of theTLR4-T399I polymorphism was associated with a 2-fold decreased risk ofHaemophilus influenzaecarriage (OR = 0.38, 95% CI = 0.15 to 0.96,P= 0.038). In the end, no significant differences were observed, considering the genotype and allele frequencies of the above-mentioned polymorphisms, between patients and controls. Our findings indicate that, regarding tonsillar infections,TLR4polymorphisms predispose individuals to GAS infection, while they are protective againstHaemophilus influenzaeinfection. This result further elucidates the role that host immune genetic variations might play in the susceptibility to common infections and tonsillar disease.

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