Clinical manifestations of obstructive sleep apnoea in pregnancy: More than snoring and witnessed apnoeas

2012 ◽  
Vol 32 (5) ◽  
pp. 434-438 ◽  
Author(s):  
G. Bourjeily ◽  
N. Barbara ◽  
L. Larson ◽  
M. He
2011 ◽  
Vol 23 (5) ◽  
pp. 201-209 ◽  
Author(s):  
Abdulkader Alam ◽  
Kadiamada Nanaiah Roy Chengappa

Alam A, Chengappa KNR. Obstructive sleep apnoea and schizophrenia: a primer for psychiatristsObjective:The main objective of this review is to improve psychiatric clinician awareness of obstructive sleep apnoea (OSA) and its potential consequences in patients with schizophrenia. This article will also discuss the diagnosis and treatment options for OSA while considering the significant role psychiatrists can play in facilitating the diagnosis and treatment of OSA.Data sources:Ovid, Medline and PsychInfo databases were searched for articles between 1960 and 2010. Search terms used wereSleep apnoeaorapnoeaandschizophreniaorpsychosis. The number of articles retrieved was 38. Articles were carefully reviewed for any data pertinent to OSA in patients with schizophrenia.Conclusions:OSA is a common disorder that is frequently unrecognised. As a chronic breathing condition, OSA is associated with adverse health outcomes and high mortality. OSA may co-occur with schizophrenia or evolve over time, especially with weight gain. The diagnosis should be considered whenever a patient presents with risk factors or clinical manifestations that are highly suggestive of OSA. Those who report snoring, daytime sleepiness and are obese or have a large neck circumference should be considered for an OSA diagnosis. Appropriate diagnosis and treatment of OSA can reduce daytime sleepiness, improve cardiovascular and other medical conditions, as well as reduce mortality. Psychiatrists can play very important role in suspecting OSA in their patients and making the initial referral. Furthermore, behavioural management, especially promoting weight loss and smoking cessation, are effective components of OSA treatment that psychiatrists are positioned to facilitate with their patients.


2007 ◽  
Vol 2 (4) ◽  
pp. 122-125
Author(s):  
Suryakant LNU ◽  
Sanjay Kumar Verma

2019 ◽  
pp. 1753495X1982596
Author(s):  
Jessica Gehlert ◽  
Adam Morton

Mineralocorticoid receptor antagonists are highly effective in the management of resistant hypertension and primary hyperaldosteronism. Recent studies demonstrate that mineralocorticoid receptor antagonists significantly reduce blood pressure, severity of obstructive sleep apnoea and arterial stiffness in patients with resistant hypertension and moderate–severe obstructive sleep apnoea. Eplerenone is a selective mineralocorticoid receptor antagonist that does not act as an androgen receptor blocker, thus reducing the risk of fetal anti-androgenic effects. Rat and rabbit studies demonstrated that when exposed to 30 times the equivalent therapeutic human dose, 100 mg/day, there were no teratogenic or demasculinisation effects. To date, the use of eplerenone has been reported in six human pregnancies in women with Gitelman syndrome, primary hyperaldosteronism and cardiac failure, in which no teratogenic effects were seen. Described here is a case of resistant hypertension associated with obstructive sleep apnoea in pregnancy, treated with eplerenone. The potential role of using eplerenone in pregnancy as treatment for resistant hypertension is discussed. Trial registration: Not applicable.


2012 ◽  
Vol 12 (3) ◽  
pp. 11-18 ◽  
Author(s):  
A Sujanska ◽  
P Durdik ◽  
P Banovcin

Abstract The authors present a recent overview of the common clinical manifestations, management, diagnostic criteria and currently accepted treatment approaches of children with obstructive sleep apnoea syndrome (OSAS). Paediatric OSAS has become widely recognized as a frequent disorder and as a major public health problem. Diagnosis of this problem is usually based on physical examination, history and clinical evaluation confirmed by the polysomnography (PSG). PSG is considering as a gold-standard test for establishing the presence and severity of sleep disordered breathing (SDB) in children. According to current understanding, OSAS is a dynamic process in which increased upper airway collapsibility is present resulting from a combination of structural and neuromotor abnormalities, rather than from structural abnormalities alone. In children the OSAS has completely different clinical features and requires different management strategy. Snoring, difficult breathing and apnoea during sleep, restless sleep, frequent awakening and behavioural disturbances are the typical symptoms usually present in children with OSAS. Nowadays, the classic presentation of child with OSAS as underweight child with adenotonsillar hypertrophy is being replaced by younger overweight or obese patients usually without the hypertrophied adenoids and tonsils. Recently it has been reported that delayed diagnosis of OSAS can lead to neurobehavioural consequences and even serious cardiorespiratory morbidity, metabolic complications, as well as an increase in insulin resistance, high blood pressure and the development of OSAS in adulthood. OSAS must be diagnosed and managed aggressively with having these new repercussions. Evidence suggests that the surgical intervention with removal of the tonsils and/or adenoids will lead to significant improvements in the most incomplicated cases, as recently reported from a meta-analysis. SDB and especially OSAS should be taken into serious consideration by pediatricians to prevent comorbidities in adulthood.


2010 ◽  
Vol 9 (2) ◽  
pp. 121 ◽  
Author(s):  
Soha Patel ◽  
Judette M Louis ◽  
◽  

The role of obstructive sleep apnoea (OSA) in pregnancy is not well studied, but an increasing body of literature appears to indicate that there may be adverse maternal and foetal health effects of the disease. OSA is associated with a twofold risk of pre-eclampsia. The small size of the existing investigations still leave unanswered questions about the consequences of OSA as it relates to some other clinically relevant outcomes such as eclampsia, stillbirth and maternal mortality. A consistent body of literature has emerged demonstrating an increased risk of insulin resistance and diabetes associated with OSA. However, among pregnant women, the association appears to be related to short sleep duration. Well-designed and adequately powered studies are needed to further delineate the role of OSA and sleep duration on pregnancy outcome and the mechanisms of those effects.


Anaesthesia ◽  
2017 ◽  
Vol 72 (12) ◽  
pp. 1564-1564 ◽  
Author(s):  
A. Miskovic ◽  
M. Simpson ◽  
J. E. Dominguez ◽  
A. S. Bullough

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