scholarly journals Obstructive Sleep Apnoea in Pregnancy – More Questions than Answers

2010 ◽  
Vol 9 (2) ◽  
pp. 121 ◽  
Author(s):  
Soha Patel ◽  
Judette M Louis ◽  
◽  
Keyword(s):  
Insulin Resistance ◽  
Sleep Duration ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Short Sleep Duration ◽  
Short Sleep ◽  
Obstructive Sleep ◽  
Increased Risk ◽  
In Pregnancy

The role of obstructive sleep apnoea (OSA) in pregnancy is not well studied, but an increasing body of literature appears to indicate that there may be adverse maternal and foetal health effects of the disease. OSA is associated with a twofold risk of pre-eclampsia. The small size of the existing investigations still leave unanswered questions about the consequences of OSA as it relates to some other clinically relevant outcomes such as eclampsia, stillbirth and maternal mortality. A consistent body of literature has emerged demonstrating an increased risk of insulin resistance and diabetes associated with OSA. However, among pregnant women, the association appears to be related to short sleep duration. Well-designed and adequately powered studies are needed to further delineate the role of OSA and sleep duration on pregnancy outcome and the mechanisms of those effects.

Obstructive Sleep Apnea in Pregnancy—More Questions than Answers

2013 ◽  
Vol 09 (02) ◽  
pp. 153
Author(s):  
Soha Patel ◽  
Judette M Louis ◽  
◽  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Duration ◽  
Short Sleep Duration ◽  
Fetal Health ◽  
Short Sleep ◽  
Obstructive Sleep ◽  
Increased Risk ◽  
In Pregnancy

The role of obstructive sleep apnea (OSA) in pregnancy is not well studied, but an increasing body of literature appears to indicate that there may be adverse maternal and fetal health effects of the disease. OSA is associated with a twofold risk for pre-eclampsia. The small size of the existing investigations still leave unanswered questions about the consequences of OSA as it relates to some other clinically relevant outcomes such as eclampsia, stillbirth, and maternal mortality. A consistent body of literature has emerged demonstrating an increased risk for insulin resistance and diabetes associated with OSA. However, among pregnant women, the association appears to be related to short sleep duration. Well-designed and adequately powered studies are required to further delineate the role of OSA and sleep duration on pregnancy outcome and the mechanisms of those effects.

scholarly journals Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study

2019 ◽  
Vol 180 (4) ◽  
pp. 265-272 ◽  
Author(s):  
Balachandran Kumarendran ◽  
Dana Sumilo ◽  
Michael W O’Reilly ◽  
Konstantinos A Toulis ◽  
Krishna M Gokhale ◽  
...  
Keyword(s):  
Cohort Study ◽  
Polycystic Ovary Syndrome ◽  
Obstructive Sleep Apnoea ◽  
Polycystic Ovary ◽  
Population Based ◽  
Sleep Apnoea ◽  
Ovary Syndrome ◽  
Obstructive Sleep ◽  
Increased Risk

Objective Obesity is very common in patients with obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS). Longitudinal studies assessing OSA risk in PCOS and examining the role of obesity are lacking. Our objective was to assess the risk of OSA in women with vs without PCOS and to examine the role of obesity in the observed findings. Design Population-based retrospective cohort study utilizing The Health Improvement Network (THIN), UK. Methods 76 978 women with PCOS and 143 077 age-, BMI- and location-matched women without PCOS between January 2000 and May 2017 were identified. Hazard ratio (HR) for OSA among women with and without PCOS were calculated after controlling for confounding variables using multivariate Cox models. Results Median patient age was 30 (IQR: 25–35) years; median follow-up was 3.5 (IQR: 1.4–7.1) years. We found 298 OSA cases in PCOS women vs 222 in controls, with incidence rates for OSA of 8.1 and 3.3 per 10 000 person years, respectively. Women with PCOS were at increased risk of developing OSA (adjusted HR = 2.26, 95% CI: 1.89–2.69, P < 0.001), with similar HRs for normal weight, overweight and obese PCOS women. Conclusions Women with PCOS are at increased risk of developing OSA compared to control women irrespective of obesity. Considering the significant metabolic morbidity associated with OSA, clinicians should have a low threshold to test for OSA in women with PCOS. Whether OSA treatment has an impact on PCOS symptoms and outcomes needs to be examined.

scholarly journals 0565 Obstructive Sleep Apnea, But Not Short Sleep Duration, is Independently Associated with Insulin Resistance: A Large-Scale Cohort Study

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A216-A217
Author(s):  
S Yin ◽  
H Xu ◽  
J Zou ◽  
C Zhang ◽  
J Guan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Duration ◽  
Large Scale ◽  
Model Assessment ◽  
Short Sleep Duration ◽  
Cross Sectional ◽  
Short Sleep ◽  
Obstructive Sleep

Abstract Introduction Both short sleep duration and obstructive sleep apnea (OSA) seem to be associated with insulin resistance. However, the majority of previous studies addressing the relationship between OSA and insulin resistance did not evaluate short sleep duration, and vice versa. In this study, we used a large-scale hospital-based cross-sectional dataset, including 5,447 participants, to examine 1) whether objectively measured short sleep duration and OSA are independently associated with insulin resistance, and 2) whether the presence of OSA modulates the association between sleep duration and insulin resistance. Methods Participants were consecutively enrolled from our sleep center during the period from 2007 to 2017. The index of homeostasis model assessment insulin resistance (HOMA-IR) was calculated from insulin and glucose. Sleep duration was determined by standard polysomnography. The associations between sleep duration and insulin resistance were estimated by logistic regression analyses. Results A total of 5,447 participants (4507 OSA and 940 primary snorers) were included in the study. In comparison to primary snorers, OSA combined with extremely short sleep duration (&lt; 5 hours) increased the risk of insulin resistance by 34% (OR, 1.34; 95% CI, 1.01-1.77) after adjusting for confounding factors that are frequently associated with insulin resistance and OSA. In subgroup analysis stratified by sleep duration, the risk of insulin resistance in patients with a short sleep duration (5-6 hours or &lt; 5 hours) was increased in those with OSA compared to primary snorers, but not in the other three sleep duration groups (6 - 7, 7 - 8, and &gt; 8 hours). Conclusion OSA, but not short sleep duration, was independently associated with insulin resistance. It is worth noting that OSA combined with extremely short sleep duration showed a greater detrimental effect than OSA itself with regard to insulin resistance. Support This study was supported by grants-in-aid from Shanghai Municipal Commission of Science and Technology (Grant No.18DZ2260200).

scholarly journals Triglyceride-Glucose Index in Non-Diabetic, Non-Obese Patients with Obstructive Sleep Apnoea

2021 ◽  
Vol 10 (9) ◽  
pp. 1932
Author(s):  
Andras Bikov ◽  
Stefan M. Frent ◽  
Martina Meszaros ◽  
Laszlo Kunos ◽  
Alexander G. Mathioudakis ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Oxygen Saturation ◽  
Obstructive Sleep Apnoea ◽  
Sleep Time ◽  
Sleep Apnoea ◽  
Obese Patients ◽  
Triglyceride Glucose Index ◽  
Cigarette Pack ◽  
Obstructive Sleep ◽  
And Control

Obstructive sleep apnoea (OSA) is associated with increased insulin resistance. Triglyceride-glucose index (TyG) is a simple marker of insulin resistance; however, it has been investigated only by two studies in OSA. The aim of this study was to evaluate TyG in non-diabetic, non-obese patients with OSA. A total of 132 patients with OSA and 49 non-OSA control subjects were included. Following a diagnostic sleep test, fasting blood was taken for the analysis of the lipid profile and glucose concentrations. TyG was calculated as ln(triglyceride [mg/dL] × glucose [mg/dL]/2). Comparison analyses between OSA and control groups were adjusted for age, gender, body mass index (BMI) and smoking. TyG was higher in men (p < 0.01) and in ever-smokers (p = 0.02) and it was related to BMI (ρ = 0.33), cigarette pack-years (ρ = 0.17), apnoea–hypopnoea index (ρ = 0.38), oxygen desaturation index (ρ = 0.40), percentage of total sleep time spent with oxygen saturation below 90% (ρ = 0.34), and minimal oxygen saturation (ρ = −0.29; all p < 0.05). TyG values were significantly higher in OSA (p = 0.02) following adjustment for covariates. OSA is independently associated with higher TyG values which are related to disease severity in non-obese, non-diabetic subjects. However, the value of TyG in clinical practice should be evaluated in follow-up studies in patients with OSA.

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