Engineering and Characterization of the Chimeric Antibody that Targets the C-terminal Telopeptide of the α2 Chain of Human Collagen I: A Next Step in the Quest to Reduce Localized Fibrosis

2013 ◽  
pp. 130222063815006
Author(s):  
Jolanta Fertala ◽  
Andrzej Steplewski ◽  
James Kostas ◽  
Pedro Beredjiklian ◽  
Gerard Williams ◽  
...  
Keyword(s):  
Collagen I ◽  
Chimeric Antibody ◽  
Human Collagen

scholarly journals Engineering and Characterization of the Chimeric Antibody That Targets the C-terminal Telopeptide of the α2 Chain of Human Collagen I: A Next Step in the Quest to Reduce Localized Fibrosis

2013 ◽  
Vol 54 (3) ◽  
pp. 187-196 ◽  
Author(s):  
Jolanta Fertala ◽  
Andrzej Steplewski ◽  
James Kostas ◽  
Pedro Beredjiklian ◽  
Gerard Williams ◽  
...  
Keyword(s):  
Collagen I ◽  
Chimeric Antibody ◽  
Human Collagen

Construction, expression and characterization of a murine/human chimeric antibody with specificity for hepatitis B surface antigen

1990 ◽  
Vol 27 (3) ◽  
pp. 303-311 ◽  
Author(s):  
Yi-Wan Li ◽  
Dawson K. Lawrie ◽  
Pallaiah Thammana ◽  
Gordon P. Moore ◽  
Clyde W. Shearman
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Chimeric Antibody

scholarly journals Characterization of morphology in healthy, traumatized and aged knee meniscus of different species: A pilot study

2019 ◽  
Vol 28 (1) ◽  
pp. 96-110
Author(s):  
Marija Podļesnaja ◽  
Mara Pilmane ◽  
Modris Ciems
Keyword(s):  
Cell Death ◽  
Pilot Study ◽  
Knee Joint ◽  
Comparative Morphology ◽  
Anatomical Structure ◽  
Collagen I ◽  
Knee Meniscus ◽  
Moderate Number ◽  
Number Of Cells

Meniscus is a fibrocartilaginous anatomical structure that realizes complicated biomechanical functions in the knee joint. However, no comparative morphology studies have been done on different species and conditions regarding the meniscus. Thus, the aim of our pilot study was to compare the morphology of traumatized and aged human and healthy deer meniscus to reveal the tissue ground, growth, degeneration, cell death and inflammation factors. The study included surgery materials from one deer and two humans. Biotin-streptavidin immunohistochemistry was performed for detection of tissue TGFβ1, MMP2, MMP9, collagen I, caspase, Il-1, Il-6, Il-10. The results were evaluated semiquantitatively. An abundant number of Collagen I positive cells were detected in the disordered human meniscus but not in the deer one. TGFβ1 was seen in numerous to abundant number of cells in all the three cases. MMPs and caspase were distributed with numerous to abundant cells in both human and deer meniscus. Numerous to abundant cells of traumatized and aged human menisci showed IL-1 and IL-6, while the deer meniscus demonstrated cytokine expression in a moderate number of cells only in limited zones. The traumatized human meniscus possessed an abundant number of IL-10 positive cells, while the deer and the aged human meniscus showed mainly a moderate number of IL-10 cells with some elevation of cytokine in superficial and deepest layers of the meniscus.

Mapping effector functions of a monoclonal antibody to GD3 by characterization of a mouse-human chimeric antibody

1994 ◽  
Vol 39 (3) ◽  
pp. 198-204 ◽  
Author(s):  
Paul B. Chapman ◽  
Stephen D. Gillies ◽  
Alan N. Houghton ◽  
Regina M. Reilly
Keyword(s):  
Monoclonal Antibody ◽  
Chimeric Antibody ◽  
Effector Functions

scholarly journals Isolation and characterization of a human collagen α 1(I)-like gene from a cosmid library

1982 ◽  
Vol 10 (6) ◽  
pp. 1981-1994 ◽  
Author(s):  
Elisabeth H. Weiss ◽  
Kathryn S.E. Cheah ◽  
Frank G Grosveld ◽  
Hans Henrik M. Dahl ◽  
Ellen Solomon ◽  
...  
Keyword(s):  
Cosmid Library ◽  
Isolation And Characterization ◽  
Human Collagen
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