Role of three-dimensional fluid-attenuated inversion recovery (3D FLAIR) and proton density magnetic resonance imaging for the detection and evaluation of lesion extent of focal cortical dysplasia in patients with refractory epilepsy

2010 ◽  
Vol 51 (2) ◽  
pp. 218-225 ◽  
Author(s):  
Jitender Saini ◽  
Atampreet Singh ◽  
Chandrasekharan Kesavadas ◽  
Bejoy Thomas ◽  
Chathurbhuj Rathore ◽  
...  
2020 ◽  
Author(s):  
Fabricio Simozo ◽  
Marcos Oliveira ◽  
Luiz Murta-Junior

Focal cortical dysplasia (FCD) is a local malformation of the cortex, the main cause of refractory epilepsy in childhood and one of the most common causes in adults. The surgery decision and planning depend on the FCD localization. Although recent studies have successfully detected FCD through artificial intelligence, no study investigates the relevance and prevalence of cortical features on FCD identification and the performance of different machine learning techniques. In this study, the proposed method constructed a voxel-based set of features, e.g., texture measure, border definition, cortical thickness.


2018 ◽  
Vol 19 ◽  
pp. 487-496 ◽  
Author(s):  
Burkhard S. Kasper ◽  
Karl Rössler ◽  
Hajo M. Hamer ◽  
Arnd Dörfler ◽  
Ingmar Blümcke ◽  
...  

Author(s):  
Tinghong Liu ◽  
Huilou Liang ◽  
Jianfei Cui ◽  
Kaibao Sun ◽  
Shaohui Zhang ◽  
...  

<b><i>Background:</i></b> Focal cortical dysplasia (FCD) is one of the most important pathogenic findings in patients with extratemporal lobe epilepsy. Magnetic resonance imaging (MRI)-negative is the most important negative factor to predict postoperative seizure freedom; however, FCD-I and part of FCD-IIa are MRI-negative on routine MRI. <b><i>Objectives:</i></b> To explore the diagnostic values of 7T MRI and its new scan sequences in epilepsy patients with FCD-IIa. <b><i>Methods:</i></b> To include patients with focal seizure and suspicious focal abnormal imaging on 3T MRI during preoperative evaluation and perform a 7T MRI scan with white matter-suppressed (WMS) and gray-white matter tissue border enhancement (GWBE) sequences, resective epilepsy surgery, and postoperative pathological finding of FCD-IIa. The preoperative qualitative and localization significance of 7T MRI and 3T MRI in lesions with FCD-IIa was compared, and then, the imaging characteristics of lesions with FCD-IIa on 7T MRI were analyzed. <b><i>Results:</i></b> Ten cases were enrolled in this study. Seven tesla MRI presented high spatial resolutions and a high signal-to-noise ratio. WMS and GWBE could selectively suppress the signal of special tissue and improved the possibility of FCD findings. FCD-IIa showed abnormal thickness of gray matter and a blurring border and was hypointense on 7T MRI compared with 3T MRI. Seven patients showed improvement in the qualitative diagnosis strength grade of FCD, and 6 subjects showed improvement in the localization strength grade of the lesion border after careful reading of the 7T MR images. Significant differences were found in the qualitative diagnosis of FCD (<i>p</i> &#x3c; 0.05) and localization of the lesion border (<i>p</i> &#x3c; 0.05) between the neuroimaging diagnoses based on 3T MRI and the findings based on 7T MRI. <b><i>Conclusion:</i></b> 7T MRI with WMS and GWBE sequences shows application value in the preoperative imaging diagnosis of lesions with FCD-IIa in epilepsy patients.


2014 ◽  
Vol 128 (2) ◽  
pp. 192-194 ◽  
Author(s):  
M Kato ◽  
N Katayama ◽  
S Naganawa ◽  
T Nakashima

AbstractObjective:We report three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging findings in a patient with relapsing polychondritis.Method:Case report.Result:A 76-year-old woman initially presented with bilateral auricular swelling together with dyspnoea. Three months later, she experienced left hearing loss and recurrent vertigo. A biopsy of the auricle was performed and relapsing polychondritis was diagnosed. The patient underwent three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging 4 hours after intravenous injection of a standard dose of gadolinium. Gadolinium enhancement was visible throughout the vestibule and the endolymphatic space could not be visualised, suggesting breakdown of the blood–labyrinth barrier.Conclusion:This is the first radiological report to demonstrate breakdown of the blood–labyrinth barrier in a case of relapsing polychondritis with inner ear impairment.


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