Development of Diclofenac Sodium Controlled Release Solid Dispersion Powders and Capsules by Freeze Drying Technique Using Ethylcellulose and Chitosan as Carriers

1998 ◽  
Vol 24 (10) ◽  
pp. 947-953 ◽  
Author(s):  
P. Dangprasirt ◽  
S. Pongwai
Keyword(s):  
Controlled Release ◽  
Solid Dispersion ◽  
Freeze Drying ◽  
Diclofenac Sodium ◽  
Controlled Release Solid Dispersion

Novel Controlled Release Solid Dispersion for the Delivery of Diclofenac Sodium

2013 ◽  
Vol 10 (4) ◽  
pp. 435-443 ◽  
Author(s):  
Tapan Kumar Giri ◽  
Kulesh Kumar ◽  
Ajazuddin ◽  
Hemant Badwaik ◽  
Minaketan Tripathy ◽  
...  
Keyword(s):  
Controlled Release ◽  
Solid Dispersion ◽  
Diclofenac Sodium ◽  
Controlled Release Solid Dispersion

Physicochemical principles of controlled release solid dispersion containing a poorly water-soluble drug

2010 ◽  
Vol 1 (1) ◽  
pp. 51-62 ◽  
Author(s):  
Thao Truong-Dinh Tran ◽  
Phuong Ha-Lien Tran ◽  
Jisung Lim ◽  
Jun Bom Park ◽  
Soon-Kuk Choi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Solid Dispersion ◽  
Water Soluble ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug ◽  
Controlled Release Solid Dispersion

Pectin-Chitosan Multilayer Coated Microbeads of Diclofenac Sodium Prepared by Layer-by-Layer Technique

2014 ◽  
Vol 1060 ◽  
pp. 45-49
Author(s):  
Kamonrak Cheewatanakornkool ◽  
Pornsak Sriamornsak
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Diclofenac Sodium ◽  
Gastric Fluid ◽  
Layer By Layer ◽  
Release Behavior ◽  
Freeze Dried ◽  
Layer Technique ◽  
Calcium Pectinate ◽  
Layer By Layer Technique

The main objective of this study was to fabricate biopolymer-based microbeads, providing enteric properties and controlled release of diclofenac sodium, using layer-by-layer technique. The calcium pectinate microbeads have been designed and coated with chitosan and pectin multilayers. Drug release was performed in simulate gastric fluid (pH 1.2) for 2 hours, followed by pH 6.8 buffer for 8 hours. The effects of chitosan concentration, number of layer and drying technique on drug release were investigated. The results showed that the calcium pectinate microbeads could be simply prepared by ionotropic gelation and then coated with chitosan and pectin solutions using layer-by-layer procedure. The diameter of the microbeads ranged from 800 to 1000 μm for air-dried samples and from 1 to 2 mm for freeze-dried samples. The freeze-dried microbeads had a rough surface and many pores inside, as observed by SEM. The microbeads coated with 4% chitosan/4% pectin revealed a slower drug release than those coated with 1% chitosan/4% pectin and demonstrated a controlled release pattern. Moreover, different drying techniques and numbers of layer also influenced drug release behavior of the prepared microbeads.

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