A Comparison of the Efficacy of Autologous Serum Eye Drops with Amniotic Membrane Transplantation in Neurotrophic Keratitis

Introduction: The management of Mooren’s ulcer can be a challenge for clinicians. Objective: To report a case of Mooren’s ulcer treated with amniotic membrane transplantation supplemented with autologous serum eye drops. Case report: A 22-year-old male presented with history of pain, redness, watering and diminution of vision of the right eye for one year. Examination of his eyes revealed the best corrected visual acuity ( BCVA) of 6\60 and 6\6 in his right and left eyes respectively. Slit -lamp examination of the right eye showed a peripheral ulcer extending from 2’0 to 11’0 clock positions with peripheral thinning and the features suggestive of Mooren’s ulcer. The condition did not improve with topical steroids and cyclosporine A eye drops. Therefore, 360 degree conjunctival peritomy with cauterization of the base was performed. Since there was no obvious improvement, the amniotic membrane transplantation was done with supplementation of autologous serum eye drops 20% four times a day. The patient showed symptomatic improvement in a week. There was cessation of the progression of the ulcer and decreased vascularization. One month later, a small corneal perforation was noted and was managed well with cyanoacrylate glue and bandage contact lens application. At nine months of follow up, the patient was symptomatically better, the ulcer had healed, the vascularization had decreased and the anterior chamber was well formed. Conclusion: Amniotic membrane transplantation showed to be promising in treatment of Mooren’s ulcer refractory to immunosuppressive therapy. Addition of autologous serum eye drops seems to be an effective supplementary therapy. Nepal J Ophthalmol 2013; 5(9):120-123 DOI: http://dx.doi.org/10.3126/nepjoph.v5i1.7839

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Autologous serum eye drops for dry eye

10.1002/14651858.cd009327.pub2 ◽

2013 ◽

Cited By ~ 21

Author(s):

Qing Pan ◽

Adla Angelina ◽

Andrea Zambrano ◽

Michael Marrone ◽

Walter J Stark ◽

...

Keyword(s):

Dry Eye ◽

Autologous Serum ◽

Eye Drops ◽

Serum Eye Drops

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Treatment of persistent epithelial defects with single-dose autologous serum eye drops

European Journal of Ophthalmology ◽

10.1177/11206721211048372 ◽

2021 ◽

pp. 112067212110483

Author(s):

Selma Özbek-Uzman ◽

Züleyha Yalnız-Akkaya ◽

Evin Şingar Özdemir ◽

Ayşe Burcu

Keyword(s):

Single Dose ◽

Healing Time ◽

Autologous Serum ◽

Eye Drops ◽

Artificial Tears ◽

Duration Of Treatment ◽

The Mean ◽

Preservative Free ◽

Serum Eye Drops

Purpose: We aimed to investigate the efficacy and safety of single-dose autologous serum eye drops (ASEDs) for treatment of persistent corneal epithelial defects (PEDs). Methods: About 34 eyes of 26 patients treated from March 2016 to May 2020 with a single dose of ASEDs for PEDs that did not respond to conventional treatment were retrospectively evaluated. Patient demographics, predisposing factors, size, and duration of the PED, duration of treatment, and dosage of ASEDs, PED healing time, success rate of the ASED treatment, and follow-up time after the onset of ASED treatment were recorded. Autologous serum eye drops (20%) were prepared by diluting the serum with preservative-free artificial tears in single-dose vials. Vials were stored at −20°C and used daily after dissolving. Results: The mean patient age was 47.0 ± 18.5 years, and 13 (50%) of the patients were male. The most common indication for ASEDs was PED after keratoplasty. The mean duration of ASED treatment was 8.5 ± 6.3 months, and mean follow-up time was 22.8 ± 12.2 months. Autologous serum eye drop treatment was effective in 25 (73.5%) eyes and partially effective in 5 (14.7%) eyes. None of the eyes displayed complications related to the treatment. Conclusion: In patients with PED for whom conservative treatment is insufficient, ASEDs prepared by dilution with preservative-free artificial tears in single-dose vials and administered based on the daily use principle appear to be effective and safe.

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