scholarly journals The Effects of the Iodinated X-Ray Contrast Media Iodixanol, Iohexol, Iopromide, and Ioversol on the Rat Kidney Epithelial Cell Line NRK 52-E

Renal Failure ◽  
2011 ◽  
Vol 33 (4) ◽  
pp. 426-433 ◽  
Author(s):  
Hanne Jensen ◽  
Richard W. Doughty ◽  
Derek Grant ◽  
Oddvar Myhre
2001 ◽  
Vol 16 (1) ◽  
pp. 5-11
Author(s):  
Takaaki KODAWARA ◽  
Ikuko YANO ◽  
Satohiro MASUDA ◽  
Tatsuya ITO ◽  
Hiroko WAKASUGI ◽  
...  

2004 ◽  
Vol 31 (4) ◽  
pp. 477-482 ◽  
Author(s):  
Naoto Shikano ◽  
Keiichi Kawai ◽  
Syuichi Nakajima ◽  
Akiko Kubodera ◽  
Nobuo Kubota ◽  
...  

2004 ◽  
Vol 18 (3) ◽  
pp. 227-234 ◽  
Author(s):  
Naoto Shikano ◽  
Keiichi Kawai ◽  
Syuichi Nakajima ◽  
Akiko Kubodera ◽  
Nobuo Kubota ◽  
...  

2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Megan Hogan ◽  
James Claffey ◽  
Eoin Fitzpatrick ◽  
Thomas Hickey ◽  
Clara Pampillón ◽  
...  

From the carbolithiation of 6-N,N-dimethylamino fulvene (3) and 2,4[bis(N,N-dimethylamino)methyl]-N-methylpyrrolyl lithium (2a), N-(N′,N′-dimethylaminomethyl)benzimidazolyl lithium (2b)' or p-(N,N-dimethylamino)methylphenyl lithium (2c), the corresponding lithium cyclopentadienide intermediate (4a–c) was formed. These three lithiated intermediates underwent a transmetallation reaction with TiCl4' resulting in N,N-dimethylamino-functionalised titanocenes 5a–c. When these titanocenes were tested against a pig kidney epithelial cell line (LLC-PK), the IC50 values obtained were of 23, and 52 μM for titanocenes 5a and 5b, respectively. The most cytotoxic titanocene in this paper, 5c with an IC50 value of 13 μM, was found to be approximately two times less cytotoxic than its analogue Titanocene C (IC50=5.5 μM) and almost four times less cytotoxic than cisplatin, which showed an IC50 value of 3.3 μM when tested on the LLC-PK cell line.


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