Classification of peripheral t-cell lymphomas: cytogenetic findings support the updated kiel classification

Abstract Cytogenetic studies on lymph node and skin biopsy specimens and peripheral blood in 104 patients with peripheral T-cell lymphomas (PTL) were compared with histopathologic diagnoses made according to the updated Kiel classification. Low-grade lymphomas presented normal metaphases more frequently than high-grade ones (P < .0001). This difference remained significant if cases with greater than 10% and greater than 50% normal metaphases in unstimulated cultures and in cultures stimulated by different mitogens were compared. On the other hand, high-grade lymphomas more often showed aberrant clones (P < .05), triploid to tetraploid clones (P < .0001), and complex clones with more than four chromosome changes (P < .01). Low-grade PTL showed consistent cytogenetic features. Clones with both inv(14)(q11q32.1) and trisomy 8q, mostly caused by i(8q)(q10), were found in all cases of T-cell chronic lymphocytic leukemia (T-CLL) and T-cell prolymphocytic leukemia (T-PLL). Trisomy 3 was observed only in angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)-type PTL, T-zone lymphoma, and lymphoepithelioid lymphoma. Moreover, the proportion of normal metaphases in these PTL was higher than in the other low-grade PTL (P < .01). On the contrary, T-CLL, T-PLL, and cutaneous T-cell lymphomas (CTCL) showed complex clones (P < .0001), duplications in 6p (P <.01), deletions in 6q (P < .01), trisomy 8q (P < .00001), inv(14) (P < .00001), and monosomy 13 or changes of 13q14 (P < .001) more frequently than the other low-grade PTL. Trisomy 5 and + X predominated in AILD- type PTL. A cytogenetic feature characteristic of AILD-type PTL and CTCL was unrelated clones, which were found in 15% of AILD-type PTL and 17% of CTCL. The only chromosome aberration restricted to a certain high-grade PTL was t(2;5)(p23;q35) in large-cell anaplastic lymphoma. Deletions in 6q, total or partial trisomies of 7q, and monosomy 13 or changes of 13q14 turned out to be significantly more frequent in high- grade than in low-grade lymphomas (P < .01, P < .01, and P < .05, respectively). In summary, the cytogenetic findings in our series of 104 PTL enabled us to distinguish not only between low-grade and high- grade lymphomas but also between various entities of PTL. Thus, the cytogenetic findings paralleled the histopathologic diagnoses made according to the updated Kiel classification.

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Classification of the Peripheral T‐cell Lymphomas

The Peripheral T‐Cell Lymphomas ◽

10.1002/9781119671336.ch6 ◽

2021 ◽

pp. 69-89

Author(s):

Neval Ozkaya ◽

Elaine S. Jaffe

Keyword(s):

T Cell ◽

T Cell Lymphomas ◽

Peripheral T Cell Lymphomas

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Aggressive Peripheral T-Cell Lymphomas (Specified and Unspecified Types)

Hematology ◽

10.1182/asheducation-2005.1.267 ◽

2005 ◽

Vol 2005 (1) ◽

pp. 267-277 ◽

Cited By ~ 33

Author(s):

Kerry J. Savage

Keyword(s):

T Cell ◽

International Prognostic Index ◽

Prognostic Index ◽

Large Cell ◽

Risk Groups ◽

T Cell Lymphomas ◽

Widespread Availability ◽

Alk Positive ◽

Peripheral T Cell Lymphomas

Abstract Peripheral T-cell lymphomas (PTCLs) are a biologically diverse and uncommon group of diseases. Compared to their B-cell counterparts, PTCLs remain largely unexplored and the optimal treatment ill-defined due to disease rarity and biological heterogeneity. For the majority of PTCL subtypes, prognosis is poor with a 5-year overall survival of approximately 30% in most series. The notable exception is ALK-positive anaplastic large-cell lymphoma (ALK-pos ALCL), which has a superior outcome. The international prognostic index can be used to some extent to define risk groups within some PTCL subtypes, including PTCL unspecified (PTCLUS). It is likely that the observed clinical heterogeneity reflects differences at the molecular level. With the more widespread availability of gene expression profiling, it may be possible in the future to further refine the classification of PTCLs and elucidate novel therapeutic targets. Future clinical trials are needed that focus specifically on PTCL to advance our understanding and define the optimal management in this disease.

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Peripheral T-cell lymphomas: an evaluation of reproducibility of the updated Kiel classification

Histopathology ◽

10.1111/j.1365-2559.1991.tb01451.x ◽

1991 ◽

Vol 18 (2) ◽

pp. 99-105 ◽

Cited By ~ 51

Author(s):

N. HASTRUP ◽

S. HAMILTON-DUTOIT ◽

E. RALFKIAER ◽

G. PALLESEN

Keyword(s):

T Cell ◽

Kiel Classification ◽

T Cell Lymphomas ◽

Peripheral T Cell Lymphomas

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Update on the World Health Organization classification of peripheral T-cell lymphomas

Current Hematologic Malignancy Reports ◽

10.1007/s11899-009-0030-5 ◽

2009 ◽

Vol 4 (4) ◽

pp. 227-235 ◽

Cited By ~ 12

Author(s):

Hilary M. O’Leary ◽

Kerry J. Savage

Keyword(s):

T Cell ◽

World Health Organization ◽

World Health ◽

World Health Organization Classification ◽

T Cell Lymphomas ◽

The World ◽

Health Organization ◽

Peripheral T Cell Lymphomas

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Cytogenetic findings in peripheral T-cell lymphomas as a basis for distinguishing low-grade and high-grade lymphomas

Blood ◽

10.1182/blood.v83.2.505.bloodjournal832505 ◽

1994 ◽

Vol 83 (2) ◽

pp. 505-511

Author(s):

B Schlegelberger ◽

A Himmler ◽

E Godde ◽

W Grote ◽

AC Feller ◽

...

Keyword(s):

T Cell ◽

The Other ◽

Low Grade ◽

High Grade ◽

Angioimmunoblastic Lymphadenopathy ◽

Prolymphocytic Leukemia ◽

Anaplastic Lymphoma ◽

Kiel Classification ◽

T Cell Lymphomas ◽

Peripheral T Cell Lymphomas

Cytogenetic studies on lymph node and skin biopsy specimens and peripheral blood in 104 patients with peripheral T-cell lymphomas (PTL) were compared with histopathologic diagnoses made according to the updated Kiel classification. Low-grade lymphomas presented normal metaphases more frequently than high-grade ones (P < .0001). This difference remained significant if cases with greater than 10% and greater than 50% normal metaphases in unstimulated cultures and in cultures stimulated by different mitogens were compared. On the other hand, high-grade lymphomas more often showed aberrant clones (P < .05), triploid to tetraploid clones (P < .0001), and complex clones with more than four chromosome changes (P < .01). Low-grade PTL showed consistent cytogenetic features. Clones with both inv(14)(q11q32.1) and trisomy 8q, mostly caused by i(8q)(q10), were found in all cases of T-cell chronic lymphocytic leukemia (T-CLL) and T-cell prolymphocytic leukemia (T-PLL). Trisomy 3 was observed only in angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)-type PTL, T-zone lymphoma, and lymphoepithelioid lymphoma. Moreover, the proportion of normal metaphases in these PTL was higher than in the other low-grade PTL (P < .01). On the contrary, T-CLL, T-PLL, and cutaneous T-cell lymphomas (CTCL) showed complex clones (P < .0001), duplications in 6p (P <.01), deletions in 6q (P < .01), trisomy 8q (P < .00001), inv(14) (P < .00001), and monosomy 13 or changes of 13q14 (P < .001) more frequently than the other low-grade PTL. Trisomy 5 and + X predominated in AILD- type PTL. A cytogenetic feature characteristic of AILD-type PTL and CTCL was unrelated clones, which were found in 15% of AILD-type PTL and 17% of CTCL. The only chromosome aberration restricted to a certain high-grade PTL was t(2;5)(p23;q35) in large-cell anaplastic lymphoma. Deletions in 6q, total or partial trisomies of 7q, and monosomy 13 or changes of 13q14 turned out to be significantly more frequent in high- grade than in low-grade lymphomas (P < .01, P < .01, and P < .05, respectively). In summary, the cytogenetic findings in our series of 104 PTL enabled us to distinguish not only between low-grade and high- grade lymphomas but also between various entities of PTL. Thus, the cytogenetic findings paralleled the histopathologic diagnoses made according to the updated Kiel classification.

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