Prenatal diagnosis of gastric and small bowel atresia: a case series and review of the literature

Background: Intestinal atresia has still significant morbidity in developing countries. Stomas are now not recommended in every case of intestinal atresia; primary anastomosis is the goal of surgery after resection of dilated adynamic gut. A new type of stoma formation along with primary anastomosis is being presented here.Materials and Methods: This report is based on our experience of many cases with this technique in last 12 years but all the details and long follow-up of each case is not available. However the method of surgical procedure, progress, complications, and advantages encountered have been highlighted.Results: Presently we have data of 7 patients; others are lost to follow up. Three had died with other associated problems, namely one with multiple atresias, two with septic shock and prematurity. Two stomas did not require formal closure because stoma shriveled and disappeared. Two other stomas had grown very long like a diverticulum when these were closed after 5 and 8 months.Conclusion: This technique is another attempt to decrease morbidity of patients of intestinal atresia especially in those cases where short bowel syndrome is feared after resection of proximal dilated gut.

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Abnormalities of the intestinal pacemaker cells, enteric neurons, and smooth muscle in intestinal atresia

Journal of Laboratory Physicians ◽

10.4103/jlp.jlp_94_18 ◽

2019 ◽

Vol 11 (03) ◽

pp. 180-185 ◽

Cited By ~ 1

Author(s):

Radhika krishna OH ◽

Mohammed Abdul Aleem ◽

Geetha Kayla

Keyword(s):

Nervous System ◽

Small Bowel ◽

Enteric Nervous System ◽

Gastrointestinal Motility ◽

Interstitial Cells Of Cajal ◽

Interstitial Cells ◽

Enteric Neurons ◽

Small Bowel Atresia ◽

Bowel Atresia ◽

Cells Of Cajal

Abstract BACKGROUND: Small bowel atresia is a congenital disorder that carves a substantial morbidity. Numerous postoperative gastrointestinal motility problems occur. The underlying cause of this motility disorder is still unclear. Interstitial cells of Cajal (ICC) play a major role in gastrointestinal motility. AIMS AND OBJECTIVES: To investigate the morphological changes of enteric nervous system and ICC in small bowel atresia. MATERIAL AND METHODS: Resected small bowel specimen from affected patients (n=15) were divided into three parts (proximal, distal, atretic). Standard histology and immunohistochemistry with anti C-KIT receptor antibody (CD117), calretinin and α-SMA was carried out. The density of myenteric ICCs in the proximal, atretic and distal parts was demonstrated by CD 117 while Calretinin was used for ganglion cells and nerve bundles, α-SMA highlighted muscle hypertrophy. RESULT AND CONCLUSION: The proximal and distal bowel revealed clear changes in the morphology and density of enteric nervous system and interstitial cells of Cajal..

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Supplementation of Mother’s Own Milk with Donor Milk in Infants with Gastroschisis or Intestinal Atresia: A Retrospective Study

Nutrients ◽

10.3390/nu12020589 ◽

2020 ◽

Vol 12 (2) ◽

pp. 589 ◽

Cited By ~ 3

Author(s):

Rebecca Hoban ◽

Supriya Khatri ◽

Aloka Patel ◽

Sharon L. Unger

Keyword(s):

Retrospective Study ◽

Small Bowel ◽

Length Of Stay ◽

Intestinal Atresia ◽

Central Line ◽

Hospital Outcomes ◽

Donor Milk ◽

Small Bowel Atresia ◽

Bowel Atresia ◽

Mother’S Own Milk

Background: Mother’s own milk (MOM) improves in-hospital outcomes for preterm infants. If unavailable, donor milk (DM) is often substituted. It is unclear if DM vs. formula to supplement MOM is associated with improved in-hospital outcomes in term/late preterm surgical infants with gastroschisis or intestinal atresia. Methods: This retrospective study included infants born ≥33 weeks gestational age (GA) with a birth weight of >1500 g who were admitted to a quaternary neonatal intensive care unit (NICU). Using Chi square and Mann-Whitney u testing, we compared hospital outcomes (length of stay, parenteral nutrition and central line days) before and after a clinical practice change to offer DM instead of formula in this surgical population. Results: Baseline characteristics were similar between eras for the 140 infants (median GA 37 weeks). Fewer infants in DM era were receiving formula at discharge (50.0% vs. 31.4%, p = 0.03). In sub-analyses including only small bowel atresia and gastroschisis infants, the median length of stay (35 vs. 25, p < 0.01) and the central line days (28 vs. 20, p < 0.01) were lower in the DM era. Conclusion: In this retrospective study, offering DM instead of formula was associated with less formula feeding at discharge, and in infants with gastroschisis or small bowel atresia, shorter length of stay and central line days.

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